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5′-Guanylic acid

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0254

  • Specification : 98.0%(HPLC)

  • CAS number : 85-32-5

  • Formula : C10H14N5O8P

  • Molecular Weight : C10H14N5O8P

  • Volume : 25mg

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Catalogue Number

BD-P0254

Analysis Method

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

C10H14N5O8P

Appearance

Botanical Source

Structure Type

Nucleosides/Nucleotide

Category

SMILES

C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(NC2=O)N.O

Synonyms

[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;hydrate

IUPAC Name

Applications

Density

2.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

481.4±37.1 °C

Boiling Point

872.4±75.0 °C at 760 mmHg

Melting Point

91 - 93ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:85-32-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32224424

Abstract

The influence of temperature-time combinations on non-volatile compound and taste traits of beef semitendinosus muscles tested by the electronic tongue was studied. Single-stage sous-vide at 60 and 70 °C (6 and 12 h), and two-stage sous-vide that sequentially cooked at 45 °C (3 h) and 60 °C (either 3 or 9 h) were compared with traditional cooking at 70 °C (30 min). Umami was better explained in the given model of partial least squares regression than astringency, sourness, saltiness, bitterness, and richness. Sous-vide at 70 °C for 12 h characterized the most umami, likely adenosine-5′-monophosphate (AMP) and guanosine-5′-monophosphate (GMP) as significant contributors. Two-stage sous-vide projected higher histidine, leucine, inosine, and hypoxanthine with the astringent and sour taste significant after 6 and 12 h cooking, respectively. Equivalent umami concentration (EUC) between umami amino acids and umami nucleotides showed a strong relationship to umami taste assessed by the electronic tongue.

KEYWORDS

Amino acids; Electronic tongue; IMP; Non-volatile; Nucleotides; Sensory; Sous-vide.

Title

Low-temperature and long-time heating regimes on non-volatile compound and taste traits of beef assessed by the electronic tongue system

Author

Ishamri Ismail 1, Young-Hwa Hwang 2, Seon-Tea Joo 3

Publish date

2020 Aug 1;

PMID

32119961

Abstract

Aims: A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp).

Materials and methods: In this study, sequence analysis, modeling, and docking are used to build a model for Wuhan COVID-19 RdRp. Additionally, the newly emerged Wuhan HCoV RdRp model is targeted by anti-polymerase drugs, including the approved drugs Sofosbuvir and Ribavirin.

Key findings: The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease.

Significance: The present study presents a perfect model for COVID-19 RdRp enabling its testing in silico against anti-polymerase drugs. Besides, the study presents some drugs that previously proved its efficiency against the newly emerged viral infection

KEYWORDS

COVID-19; Docking; Nucleotide inhibitors; RdRp; Sofosbuvir; Structural bioinformatics; Wuhan coronavirus.

Title

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

Author

Abdo A Elfiky 1

Publish date

2020 May 1;

PMID

32025667

Abstract

Expanding the catalytic repertoire of ribozymes to include vitamin synthesis requires efficient labelling of RNA with the substrate of interest, prior to in vitro selection. For this purpose, we rationally designed and synthesized six GMP-conjugates carrying a synthetic pre-thiamine or biotin precursor and investigated their transcription incorporation properties by T7 RNA polymerase.

Title

Vitamin-guanosine monophosphate conjugates for in vitro transcription priming

Author

Nikolaos Papastavrou 1, Omprakash Bande 1, Philippe Marliere 2, Elisabetta Groaz 1, Piet Herdewijn 1

Publish date

2020 Mar 3