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5-hydroxytryptophan

$64

  • Brand : BIOFRON

  • Catalogue Number : BD-D0011

  • Specification : HPLC≥98%

  • CAS number : 4350-09-8

  • Formula : C11H12N2O3

  • Molecular Weight : 220.22

  • Volume : 100mg

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Catalogue Number

BD-D0011

Analysis Method

Specification

HPLC≥98%

Storage

2-8°C

Molecular Weight

220.22

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N

Synonyms

Telesol/Oxyfan/oxitriptan/Cincofarm/Levothym/Oxitriptan 1/5-hydroxy-L-tryptophan zwitterion/5-Hydroxyl-L-tryptophan/L-5HTP/L-Tryptophan, 5-hydroxy-/(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid/5-Hydroxy-L-tryptophan/Serotonyl/L-5-Hydroxytryptophan/L-5-HTP L-2-Amino-3-(5-hydroxyindolyl)propionic acid/Tryptophan, 5-hydroxy-, L-

IUPAC Name

Applications

Density

1.5±0.1 g/cm3

Solubility

Flash Point

268.7±30.1 °C

Boiling Point

520.6±50.0 °C at 760 mmHg

Melting Point

270 °C (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:4350-09-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30983991

Abstract

Gardenia jasminoides Ellis, which belongs to the Rubiaceae family, is a widely used traditional Chinese medicine. Although effect of Gardenia jasminoides Ellis has been widely reported, its anti-inflammatory role in intestinal mucosal injury induced by LPS remains unclear. In the present study, we investigated the effects of decoction extracted from Gardenia jasminoides on the morphology and intestinal antioxidant capacity of duodenum induced by LPS in mice. Further analysis was carried out in the expression of inflammatory and anti-inflammatory cytokines. Nuclear factor-kappa B (NF-κB) was determined by Western blot. Gardenia jasminoides water extract was qualitative analyzed by high-performance liquid chromatography coupled with electro spray ionization quadrupole time-of-flight mass spectrometry. The results showed that Gardenia decoction markedly inhibited the LPS-induced Tumor necrosis factor (TNF)-α, Interleukin (IL)-6, IL-8, and IL-1 production. It was also observed that Gardenia decoction attenuated duodenum histopathology changes in the mouse models. Furthermore, Gardenia decoction inhibited the expression of NF-κB in LPS stimulated mouse duodenum. These results suggest that Gardenia decoction exerts an anti-inflammatory and antioxidant property by up-regulating the activities of the total antioxidant capacity (T-AOC), the total superoxide dismutase (T-SOD), and glutathione peroxidase (GSH-Px). Gardenia decoction is highly effective in inhibiting intestinal mucosal damage and may be a promising potential therapeutic reagent for intestinal mucosal damage treatment.

KEYWORDS

Gardenia jasminoides, decoction, Lipopolysaccharide, cytokine, NfκB

Title

Gardenia Decoction Prevent Intestinal Mucosal Injury by Inhibiting Pro-inflammatory Cytokines and NF-κB Signaling

Author

Yizhe Cui,† Qiuju Wang,† Mengzhu Wang, Junfeng Jia, and Rui Wu*

Publish date

2019