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provides coniferyl ferulate(CAS#:499-75-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Carvacrol is a monoterpenic phenol produced by an abundant number of aromatic plants, including thyme and oregano. Presently, carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations. In recent years, considerable research has been undertaken in an effort to establish the biological actions of carvacrol for its potential use in clinical applications. Results from in vitro and in vivo studies show that carvacrol possess a variety of biological and pharmacological properties including antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant. The focus of this review is to evaluate the existing knowledge regarding the biological, pharmacological, and toxicological effects of carvacrol.
herbs; oregano; thyme; toxicity
The bioactivity and toxicological actions of carvacrol.
Suntres ZE1, Coccimiglio J, Alipour M.
Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic neuronal injury. In this study, we investigated the effects of carvacrol (i.p.) upon the neurodegeneration induced by 6-hydroxy-dopamine unilateral intrastriatal injections in mice. We have also used the cylinder test to assess the behavioral effects of carvacrol in that model of Parkinson’s disease, and immunoblots to evaluate the levels of caspase-3 and TRPM7, one of major targets of carvacrol. Behavioral testing revealed that carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Immunoblots for tyrosine hydroxylase confirmed this effect. Caspase-3 levels were very high after toxin injections, but carvacrol appeared to reduce them to control levels. Finally, TRPM7, observed by immunoblots, increased after 6-hydroxy-dopamine, suggesting the involvement of this cation channel in the ensuing neurodegenerative process. The present data suggest that carvacrol promotes a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson’s disease, possibly by its non-specific blocking effect upon TRPM7 channels.
Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
TRP channels; carvacrol; dopamine; neuroprotection
Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model.
Dati LM1, Ulrich H2, Real CC1, Feng ZP3, Sun HS4, Britto LR5.
2017 Jul 25
This study evaluated the larvicidal activity, and ovicidal activity of Origanum vulgare EO and its major components against the cotton bollworm, Helicoverpa armigera. The chemical composition of the O. vulgare EO was analyzed by gas chromatography-mass spectroscopy. GC-MS analysis revealed that the O. vulgare EO was composed of ten compounds. The major constituents were carvacrol (78.35%), followed by p-cymene (6.85%) and γ-terpinene (3.70%). In larvicidal activity assay, the O. vulgare EO achieved a LC50 value of 265.51 μg/ml. The three major constituents from the O. vulgare EO were tested individually for toxicity against larvae of H. armigera. Carvacrol, p-cymene, and γ-terpinene appeared to be most effective against H. armigera, with LC50 values of 51.53, 121.32, and 150.15 μg/ml, respectively. Moreover, EC50 values of carvacrol, p-cymene, and γ-terpinene against H. armigera eggs were 33.48, 47.85, and 56.54 μg/ml, respectively. Overall, this study showed that O. vulgare EO and its major constituents have the potential to develop as new eco-friendly insecticides against H. armigera.
Botanical insecticides; Carvacrol; Helicoverpa armigera; Larvicidal activity; Origanum vulgare; Ovicidal activity
Larvicidal and ovicidal activity of carvacrol, p-cymene, and γ-terpinene from Origanum vulgare essential oil against the cotton bollworm, Helicoverpa armigera (Hubner).
Gong X1, Ren Y2,3.
2020 Mar 23
Carvacrol is a monoterpenoid phenol isolated from Lamiaceae family plants, with antioxidant, anti-inflammatory and anticancer properties. Carvacrol causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis.