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5-O-Methylvisammioside

$113

  • Brand : BIOFRON

  • Catalogue Number : BF-O3003

  • Specification : 98%

  • CAS number : 84272-85-5

  • Formula : C22H28O10

  • Molecular Weight : 452.453

  • PUBCHEM ID : 21670038

  • Volume : 25mg

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Catalogue Number

BF-O3003

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

452.453

Appearance

White crystalline powder

Botanical Source

Saposhnikovia divaricata

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CC(=O)C2=C(C3=C(C=C2O1)OC(C3)C(C)(C)OC4C(C(C(C(O4)CO)O)O)O)OC

Synonyms

N1895/4'-O-beta-D-Glucosyl-5-O-methylvisamminol/5H-Furo[3,2-g][1]benzopyran-5-one, 2-[1-(β-D-glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-4-methoxy-7-methyl-, (2S)-/5-O-Methylvisammioside/2-[(2S)-4-Methoxy-7-methyl-5-oxo-2,3-dihydro-5H-furo[3,2-g]chromen-2-yl]-2-propanyl β-D-glucopyranoside/4'-O-glucopyranosyl-5-O-methylvisamminol/4'-O-Beta-D-Gulcosyl-5-O-methylvisamminol/O-Methylvisammioside, 5-

IUPAC Name

(2S)-4-methoxy-7-methyl-2-[2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropan-2-yl]-2,3-dihydrofuro[3,2-g]chromen-5-one

Density

1.5±0.1 g/cm3

Solubility

Methanol

Flash Point

239.1±25.0 °C

Boiling Point

690.4±55.0 °C at 760 mmHg

Melting Point

148-150ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:84272-85-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30969007

Abstract

5-O-Methylvisammioside is one of major chromones of Radix Saposhnikoviae possessing definite pharmacological activities, but there are few reports with respect to the metabolism of 5-O-methylvisammioside. In this work, metabolites in vivo were explored in male Sprague-Dawley rats and in vitro investigated on rat intestinal bacteria incubation model and were identified by using ultra high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. An online data acquisition method based on a multiple mass defect filter and dynamic background subtraction was developed to trace all probable metabolites. As a result, 26 metabolites in vivo (including 18, 15, 10, and 10 in rat urine, faece, bile, and blood) and 7 metabolites in vitro were characterized, respectively. Additionally, the main metabolic pathways in vivo and in vitro, including deglycosylation, deglycosylation + demethylation, deglycosylation + oxidation, N-acetylation, and sulfate conjugation, were summarized by calculating the relative content of each metabolite. The obtained results significantly enriched our knowledge about 5-O-methylvisammioside metabolism and will lead to a better understanding of its safety and efficacy.

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS

5-O-methylvisammioside; mass spectrometry; metabolites; traditional Chinese medicine; ultra high performance liquid chromatography

Title

Metabolites study on 5-O-methylvisammioside in vivo and in vitro by ultra high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.

Author

Fan X1, Liu X1, Meng C1, Liu R1, Zhang Z2, Wang C1.

Publish date

2019 Jun

PMID

29082705

Abstract

In this experiment, rat nasal mucosa absorption characteristics of prim-O-glucosylcimifugin and 5-O-methylvisammioside were studied to provide a basis for drug delivery of Toutongning nasal spray. The nasal mucosa absorption test in rats was conducted with in situ nasal perfusion method after pH 6 buffer solution was used to prepare high, medium and low concentrations of prim-O-glucosylcimifugin, 5-O-methylvisammioside mixed solution as liquid circulation in nasal cavity. Then the concentrations of the circulating liquid compositions to be measured were determined by HPLC, and the absorption rates of prim-O-glucosylcimifugin and 5-O-methylvisammioside under different pH conditions were also investigated. According to the results, the absorption rate constant was (0.588±0.041)×10⁻³, (0.547±0.023)×10⁻³, (0.592±0.063)×10⁻³ min⁻¹ for prim-O-glucosylcimifugin high, middle and low concentrations, and (0.438±0.041)×10⁻³, (0.407±0.023)×10⁻³, and (0.412±0.063)×10⁻³ min⁻¹ for 5-O-methylvisammioside high, middle and low concentrations. There was no significant difference among high, middle and low concentration groups, and the absorption under pH 6 was better than that under other pH conditions. Therefore, we can get the conclusion that the main active ingredient of Toutongning nasal sprays can be absorbed through the nasal mucosa, and it is feasible to make nasal spray; in addition, pH 6 of nasal spray is scientific and reasonable.

Copyright© by the Chinese Pharmaceutical Association.

KEYWORDS

5-O-methylvisammioside ; nasal circulatory perfusion ; prim-O-glucosylcimifugin

Title

[Nasal resorption of prim-O-glucosylcimifugin and 5-O-methylvisammioside in rats].

Author

Wang TF1,2, Wang JP2, Pan JH1,2, Jiang ZT2, Chen XF2, Wang JC2.

Publish date

2017 May


Description :

5-O-Methylvisammioside is a natural product isolated from Saposhnikovia Divaricata.