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6-Demethoxytangeretin

$300

  • Brand : BIOFRON

  • Catalogue Number : BF-D4011

  • Specification : 98%(HPLC)

  • CAS number : 6601-66-7

  • Formula : C19H18O6

  • Molecular Weight : 342.347

  • PUBCHEM ID : 629964

  • Volume : 25mg

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Catalogue Number

BF-D4011

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

342.347

Appearance

Palm red crystalline powder

Botanical Source

Citrus reticulata

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3OC)OC)OC

Synonyms

6-Demethoxytangeretin/4',5,7,8-Tetramethoxyflavone/5,7,8-Trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one/4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-(4-methoxyphenyl)-/5,7,8,4'-tetramethoxyflavone/6-Demethoxytangeritin/Tetra-O-methylisoscutellarein/tetramethyl-o-isoscutellarein

IUPAC Name

5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one

Density

1.243±0.06 g/cm3

Solubility

Methanol; DMF

Flash Point

237.5±30.2 °C

Boiling Point

536.9±50.0 °C at 760 mmHg

Melting Point

216-217 ºC

InChl

InChI=1S/C19H18O6/c1-21-12-7-5-11(6-8-12)14-9-13(20)17-15(22-2)10-16(23-3)18(24-4)19(17)25-14/h5-10H,1-4H3

InChl Key

DDGJUTBQQURRGE-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6601-66-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

24500009

Abstract

Citrus species has been traditionally used in Korea for the treatment of coughing, sputum and dyspepsia. Of the known citrus flavonoids, 6-demethoxytangeretin was reported to exert anti-inflammatory activity. In order to determine the anti-allergic activity of 6-demethoxytangeretin, we examined whether or not 6-demethoxytangeretin was able to suppress activation of the human mast cell line, HMC-1, induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. Interleukin-6 production and relevant gene expression in activated HMC-1 cells were determined by enzyme-linked immunosorbent assay (ELISA) and quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis. Also, the involvement of the anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinases (MAPKs) in activated HMC-1 cells were studied. 6-Demethoxytangeretin suppresses interleukin-6 production, tumor necrosis factor-alpha gene expression, ALK and MAPKs in HMC-1 cells stimulated by PMA plus A23187. Therefore, it was evident that 6-demethoxytangeretin suppressed activation of HMC-1 cells by PMA plus A23187 by inhibiting the activity of ALK and MAPKs and subsequently suppressing gene expression, which suggest that 6-demethoxytangeretin may be involved in the regulation of mast cell-mediated inflammatory responses.

Title

A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways.

Author

Kim YM1, Chae HS, Lee EJ, Yang MH, Park JH, Yoon KD, Kim J, Ahn HC, Choi YH, Chin YW.

Publish date

2014


Description :

6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].