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6-Ethoxychelerythrine

$576

Brand : BIOFRON
Catalogue Number : BN-O0024
Specification : 98%(HPLC)
CAS number : 79559-55-0
Formula : C23H22NO5
Molecular Weight : 392.43
Volume : 10mg

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Catalogue Number

BN-O0024

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

392.43

Appearance

Botanical Source

Structure Type

Category

SMILES

CCOC1=CC2=C3C=CC(=C(C3=C[N+](=C2C4=CC5=C(C=C41)OCO5)C)OC)OC

Synonyms

6-ethoxy-1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium

IUPAC Name

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

164.3±27.3 °C

Boiling Point

563.9±50.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:79559-55-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

24748570

Abstract

Background
The Women’s Health Initiative (WHI) randomized trials found that use of combined estrogen and progestin menopausal hormone therapy (CHT) increases breast cancer risk, but use of unopposed estrogen hormone therapy (EHT) does not. However, several questions regarding the impact of hormone use on risk of different types of breast cancer and what thresholds of use confer elevations in risk remain.

Methods
We conducted a population-based case-control study among women 55-74 years of age to assess the association between menopausal hormone use and risk of invasive ductal and invasive lobular breast carcinomas. Associations were evaluated using polytomous logistic regression and analyses included 880 ductal cases, 1,027 lobular cases, and 856 controls.

Results
Current EHT and CHT use were associated with 1.6-fold [95% confidence interval (CI): 1.1-2.2] and 2.3-fold (95% CI: 1.7-3.2) increased risks of lobular breast cancer, respectively, but neither was associated with risk of ductal cancer. Lobular cancer risk was increased after nine years of EHT use, but after only three years of CHT use.

Discussion
Evidence across more than a dozen studies indicates that lobular carcinoma is the type of breast cancer most strongly influenced by menopausal hormones. Here we characterize what thresholds of duration of use of both EHT and CHT that confer elevations in risk.

Impact
Despite the rapid decline in hormone therapy use the WHI results were published, study of the hazards associated with these medications remains relevant given the estimated 38 million hormone therapy prescriptions that are still filled in the United States annually.

Title

Use of menopausal hormone therapy and risk of ductal and lobular breast cancer among women 55-74 years of age

Author

Christopher I. Li, MD, PhD,1 Janet R. Daling, PhD,1 Kara L. Haugen, MS,1 Mei Tzu Chen Tang, PhD,1 Peggy L. Porter, MD,1,2 and Kathleen E. Malone, PhD1

Publish date

2015 Jun 1.

PMID

24195573

Abstract

Background
According to the US Environmental Protection Agency (EPA), Superfund is a federal government program implemented to clean up uncontrolled hazardous waste sites. Twenty-six sites in South Carolina (SC) have been included on the National Priorities List (NPL), which has serious human health and environmental implications. The purpose of this study was to assess spatial disparities in the distribution of Superfund sites in SC.

Methods
The 2000 US census tract and block level data were used to generate population characteristics, which included race/ethnicity, socioeconomic status (SES), education, home ownership, and home built before 1950. Geographic Information Systems (GIS) were used to map Superfund facilities and develop choropleth maps based on the aforementioned sociodemographic variables. Spatial methods, including mean and median distance analysis, buffer analysis, and spatial approximation were employed to characterize burden disparities. Regression analysis was performed to assess the relationship between the number of Superfund facilities and population characteristics.

Results
Spatial coincidence results showed that of the 29.5% of Blacks living in SC, 55.9% live in Superfund host census tracts. Among all populations in SC living below poverty (14.2%), 57.2% were located in Superfund host census tracts. Buffer analyses results (0.5mi, 1.0mi, 5.0mi, 0.5km, 1.0km, and 5.0km) showed a higher percentage of Whites compared to Blacks hosting a Superfund facility. Conversely, a slightly higher percentage of Blacks hosted (30.2%) a Superfund facility than those not hosting (28.8%) while their White counterparts had more equivalent values (66.7% and 67.8%, respectively). Regression analyses in the reduced model (Adj. R2 = 0.038) only explained a small percentage of the variance. In addition, the mean distance for percent of Blacks in the 90th percentile for Superfund facilities was 0.48mi.

Conclusion
Burden disparities exist in the distribution of Superfund facilities in SC at the block and census tract levels across varying levels of demographic composition for race/ethnicity and SES.

Title

Spatial disparity in the distribution of superfund sites in South Carolina: an ecological study

Author

Kristen Burwell-Naney,corresponding author1,2 Hongmei Zhang,3 Ashok Samantapudi,3 Chengsheng Jiang,1,2 Laura Dalemarre,2 LaShanta Rice,4 Edith Williams,3,5 and Sacoby Wilson1,2

Publish date

2013;

PMID

32012192

Abstract

This paper examines the financial stability of banks that issued securitizations in the European market from 2000 to 2017. We use novel event study methodology and find that securitization has a positive impact on European banks’ systematic risk during the 2000 to 2007 period and that subsequent securitizations have not any impact on systematic risk. The increase in systematic risk is due to an increase in systemic risk and in banks’ idiosyncratic risk. By dividing the sample into those countries on the periphery and those at the core of Europe, it is found that securitization only has an impact on the systematic risk during the pre-crisis period, and only when looking at the peripheral countries does this lead to an increase in systemic risk. For individual countries, there is an observable effect for Spain and the UK prior to the crisis. On controlling for the type of collateral, it is found that this effect occurs when dealing with mortgage-based securitizations.

Title

Securitization, financial stability and effective risk retention. A European analysis

Author

Ana Iglesias-Casal, Data curation, Formal analysis, Investigation, Methodology, Writing - original draft,1,* Maria-Celia Lopez-Penabad, Data curation, Formal analysis, Investigation, Methodology, Writing - original draft,2 Carmen Lopez-Andion, Data curation, Formal analysis, Investigation, Methodology, Writing - original draft,1 and Jose Manuel Maside-Sanfiz, Data curation, Formal analysis, Investigation, Methodology, Writing - original draft2 Jordi Paniagua, Editor

Publish date

2020;