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6-Gingerol

$87

  • Brand : BIOFRON

  • Catalogue Number : BD-D1356

  • Specification : 98%(HPLC)

  • CAS number : 23513-14-6

  • Formula : C17H26O4

  • Molecular Weight : 294.39

  • PUBCHEM ID : 442793

  • Volume : 20MG

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Catalogue Number

BD-D1356

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

294.39

Appearance

White waxy solid

Botanical Source

Pueraria lobata (Willd.) Ohwi/ginger (Zingiber officinale)

Structure Type

Simple Phenolic Compounds

Category

Standards;Natural Pytochemical;API

SMILES

CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O

Synonyms

3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-/(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one/3-Decanone (5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)/(+)-Gingerol/(S)-[6]Gingerol/(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone/3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-/3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-/(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone/(S)-(+)-[6]Gingerol/(+)-[6]-Gingerol/6-Gingerol/(S)-(6)-Gingerol/(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one/Gingerol/(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone/(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one/[6]-Gingerol

IUPAC Name

(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

Applications

[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

Density

1.1±0.1 g/cm3

Solubility

Methanol; Acetone

Flash Point

159.0±19.4 °C

Boiling Point

453.0±35.0 °C at 760 mmHg

Melting Point

30 - 32ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:23513-14-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30257370

Abstract

6-Gingerol, the major component of gingerols extracted from Zingiber officinale, has been shown to exhibit anti-inflammatory and antioxidant bioactivities. Since neuroinflammation plays an important role in neurodegenerative diseases, such as Alzheimer’s disease (AD), and astrocytes have been considered important in the process of neurodegeneration, it was of interest to know whether 6-gingerol reduced astrocytes activation or even attenuated cognitive impairment. Here we examined the neuroprotective effects of 6-gingerol in lipopolysaccharide (LPS)-induced disorder models both in vitro and in vivo. C6 astroglioma cells treated with LPS were found to release excessive pro-inflammatory cytokines, including TNF-α and IL-6, and also increase intercellular ROS, NO, and iNOS (i.e. NOS2). All these were blocked by 6-gingerol in a concentration-dependent manner. The spatial learning and memory of rats challenged with LPS (10 μg, i.c.v.) in the absence or presence of 6-gingerol were evaluated using the Morris water-maze (MWM) test. 6-Gingerol attenuated LPS-induced imapirement of MWM learning and memory in a dose-dependent manner. Besides, 6-gingerol inhibited LPS-induced increases in levels of GFAP and TNF-α in the rat brain. The results suggest that 6-gingerol suppresses astrocyte overactivation, through which it contributes to improvement of cognitive ability.

KEYWORDS

6-Gingerol; Astrocyte; Learning and memory; Neuroinflammation; Oxidative stress.

Title

6-Gingerol Attenuates LPS-induced Neuroinflammation and Cognitive Impairment Partially via Suppressing Astrocyte Overactivation

Author

Feng Zhang 1 , Ji-Guo Zhang 1 , Wei Yang 2 , Pu Xu 2 , Yu-Liang Xiao 1 , Han-Ting Zhang 3

Publish date

2018 Nov

PMID

29267793

Abstract

6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-β participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-β concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.

KEYWORDS

6-Gingerol; Astrocyte; Learning and memory; Neuroinflammation; Oxidative stress.

Title

6-Gingerol Inhibits Hair Cycle via Induction of MMP2 and MMP9 Expression

Author

Chun Hou 1 , Yong Miao 2 , Hang Ji 1 , Susheng Wang 1 , Gang Liang 1 , Zhihua Zhang 1 , Weijin Hong

Publish date

Oct-Dec 2017

PMID

29512739

Abstract

Ionizing radiation (IR) is the main modality for locoregional control of unresectable gastric cancer (GC). [6]-Gingerol is an active major phenolic compound isolated from ginger (Zingiber officinale Roscoe), and it has been demonstrated to possess antitumor activity in previous studies. In the present study, we aimed to evaluate the potential activity of [6]-gingerol as a radiosensitizer and to further explore the underlying mechanism. A CCK-8 assay revealed that [6]-gingerol inhibited the cell viability of HGC-27 cells in a dose-dependent manner (P<0.05). Colony formation assay indicated that pretreatment of [6]-gingerol prior to IR decreased the clonogenic survival of HGC-27 cells. Notably, the combination of [6]-gingerol with IR enhanced IR-induced cell cycle arrest at the G2/M phase compared with IR alone (41.3% in IR alone vs. 53.5% in [6]-gingerol+IR; P=0.006), and increased IR-induced apoptosis compared with IR alone (9.6% in IR alone group vs. 15.1% in [6]-gingerol+IR; P=0.07). DAPI staining detected the apoptotic nuclear morphological changes in the cells treated with [6]-gingerol and/or IR. Furthermore, western blotting and qRT-PCR revealed that [6]-gingerol pretreatment following IR downregulated the protein expression of cyclin B1, cyclin A2, CDC2 and cyclin D1, upregulated the mRNA expression of p27, and induced active caspase-9, active caspase-3 and cytochrome c. In conclusion, the present study demonstrated that [6]-gingerol enhanced radiosensitivity of GC cells, and that the mechanisms involved at least G2/M phase arrest and apoptosis induction.

Title

[6]-Gingerol Enhances the Radiosensitivity of Gastric Cancer via G2/M Phase Arrest and Apoptosis Induction

Author

Youjun Luo 1 , Xue Chen 1 , Lumeng Luo 1 , Qi Zhang 1 , Caixia Gao 1 , Xibing Zhuang 1 , Sujuan Yuan 1 , Tiankui Qiao 1

Publish date

2018 May