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6-hydroxyl kaempherol-3,6-O-diglucosyl-7-O-Glucuronic acid

$1,671

  • Brand : BIOFRON

  • Catalogue Number : BN-O1511

  • Specification : 98%(HPLC)

  • CAS number : 307950-53-4

  • Formula : C33H38O23

  • Molecular Weight : 802.6

  • PUBCHEM ID : 102240411

  • Volume : 5mg

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Catalogue Number

BN-O1511

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

802.6

Appearance

Botanical Source

Structure Type

Category

SMILES

Synonyms

IUPAC Name

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,6-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]chromen-7-yl]oxyoxane-2-carboxylic acid

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

AAKJOZZAGIRTOJ-JOFBQTNNSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:307950-53-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

22905146

Abstract

GDF5 is a member of the bone morphogenetic protein (BMP) gene family, and plays an important role in the development of the skeletal system. Variants of the gene are associated with osteoarthritis and height in some human populations. Here, we resequenced the gene in individuals from four geographically separated human populations, and found that the evolution of the promoter region deviated from neutral expectations, with the sequence evolution driven by positive selection in the East Asian population, especially the haplotypes carrying the derived alleles of 5′ UTR SNPs rs143384 and rs143383. The derived alleles of rs143384 and rs143383, which are associated with a risk of osteoarthritis and decreased height, have high frequencies in non-Africans and show strong extended haplotype homozygosity and high population differentiation in East Asian. It is concluded that positive selection has driven the rapid evolution of the two osteoarthritis osteoarthritis-risk and decreased height associated variants of the human GDF5 gene, and supports the suggestion that the reduction in body size during the terminal Pleistocene and Holocene period might have been an adaptive process influenced by genetic factors.

Title

Positive Selection on the Osteoarthritis-Risk and Decreased-Height Associated Variants at the GDF5 Gene in East Asians

Author

Dong-Dong Wu,# 1 Gui-Mei Li,# 2 Wei Jin, 2 Yan Li, 1 and Ya-Ping Zhang 1 , 2 , * Thomas Mailund, Editor

Publish date

2012

PMID

29918664

Title

Medical Statistics

Publish date

1841 Jan 1;


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