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6-Methoxydihydrosanguinarine

$896

  • Brand : BIOFRON

  • Catalogue Number : BD-P0227

  • Specification : 99.0%(HPLC)

  • CAS number : 151890-26-5

  • Formula : C21H17NO5

  • Molecular Weight : 364

  • PUBCHEM ID : 135394272

  • Volume : 25mg

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Catalogue Number

BD-P0227

Analysis Method

HPLC,NMR,MS

Specification

99.0%(HPLC)

Storage

2-8°C

Molecular Weight

364

Appearance

Off-white crystalline powder

Botanical Source

Structure Type

Quinolines/Isoquinolines

Category

Standards;Natural Pytochemical;API

SMILES

CN1C(C2=CC3=C(C=C2C4=C1C5=CC6=C(C=C5C=C4)OCO6)OCO3)OC

Synonyms

1,3-Benzodioxolo[5,6-c][1,3]dioxolo[4,5-j]phenanthridine,5,6-dihydro-6-methoxy-5-methyl-

IUPAC Name

11-methoxy-12-methyl-5,7,17,19-tetraoxa-12-azahexacyclo[11.11.0.02,10.04,8.014,22.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene

Applications

6-Methoxy Dihydrosanguinarine is an lkaloid isolated from the fruits of M.cordata. 6-Methoxy Dihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively[1].

Density

Solubility

Methanol

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C21H17NO5/c1-22-20-12(4-3-11-5-16-17(6-13(11)20)25-9-24-16)14-7-18-19(27-10-26-18)8-15(14)21(22)23-2/h3-8,21H,9-10H2,1-2H3

InChl Key

ZXAGLUIVEUDJAR-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:151890-26-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29765732

Abstract

Crystal structure determination of doxorubicin nitrate, (DoxH)NO3, systematic name (7S,9S)-7-{[(2R,4S,5S,6S)-4-azaniumyl-5-hy­droxy-6-methyl­oxan-2-yl]­oxy}-6,9,11-trihy­droxy-9-(2-hy­droxy­acet­yl)-4-meth­oxy-8,10-di­hydro-7H-tetra­cen-5,12-dione nitrate, shows two formula units present in the asymmetric unit. In the crystal lattice, hydrogen-bonded pairs of (DoxH+) cations and segregation of the aglycone and sugar moieties are observed. Inspection of mol­ecular overlays reveals that the conformation of (DoxH)NO3 resembles that of DNA-inter­calated, but not of protein-docked (DoxH)+. The structure was refined as a two-component twin.

KEYWORDS

doxorubicin, anthracycline, conformation, inter­calation, crystal structure

Title

Crystal structure and conformational analysis of doxorubicin nitrate

Author

Logesh Mathivathanan,a,* Guang Yang,a,b Fenfei Leng,a and Raphael G. Raptisa

Publish date

2018 Feb 28

PMID

31695964

Abstract

The medicinal orchid genus Dendrobium belonging to the Orchidaceae family is a huge genus comprising about 800-1,500 species. To better illustrate the species status in the genus Dendrobium, a comparative analysis of 33 available chloroplast genomes retrieved from NCBI RefSeq database was compared with that of the first complete chloroplast genome of D. nobile from north-east India based on next-generation sequencing methods (Illumina HiSeq 2500-PE150). Our results provide comparative chloroplast genomic information for taxonomical identification, alignment-free phylogenomic inference and other statistical features of Dendrobium plastomes, which can also provide valuable information on their mutational events and sequence divergence.

KEYWORDS

Dendrobium, Next generation sequencing, Chloroplast, RNA editing, Codon usage, SNP

Title

The complete chloroplast genome of Dendrobium nobile, an endangered medicinal orchid from north-east India and its comparison with related Dendrobium species

Author

Ruchishree Konhar,1,2,3 Manish Debnath,1 Santosh Vishwakarma,1 Atanu Bhattacharjee,1 Durai Sundar,4 Pramod Tandon,5 Debasis Dash,corresponding author2,3 and Devendra Kumar Biswalcorresponding author1

Publish date

2019 Nov 1

PMID

25473826

Abstract

Circulating extra-cellular microRNAs (miRNAs) have emerged as promising minimally invasive markers in human medicine. We evaluated miRNAs isolated from total plasma as biomarker candidates of a response to an abiotic stress (feed deprivation) in a livestock species. Two chicken lines selected for high (R+) and low (R−) residual feed intake were chosen as an experimental model because of their extreme divergence in feed intake and energy metabolism. Adult R+ and R− cocks were sampled after 16 hours of feed deprivation and again four hours after re-feeding. More than 292 million sequence reads were generated by small RNA-seq of total plasma RNA. A total of 649 mature miRNAs were identified; after quality filtering, 148 miRNAs were retained for further analyses. We identified 23 and 19 differentially abundant miRNAs between feeding conditions and between lines respectively, with only two miRNAs identified in both comparisons. We validated a panel of six differentially abundant miRNAs by RT-qPCR on a larger number of plasma samples and checked their response to feed deprivation in liver. Finally, we evaluated the conservation and tissue distribution of differentially abundant miRNAs in plasma across a variety of red jungle fowl tissues. We show that the chicken plasma miRNome reacts promptly to the alteration of the animal physiological condition driven by a feed deprivation stress. The plasma content of stress-responsive miRNAs is strongly influenced by the genetic background, with differences reflecting the phenotypic divergence acquired through long-term selection, as evidenced by the profiles of conserved miRNAs with a regulatory role in energy metabolism (gga-miR-204, gga-miR-let-7f-5p and gga-miR-122-5p). These results reinforce the emerging view in human medicine that even small genetic differences can have a considerable impact on the resolution of biomarker studies, and provide support for the emerging interest in miRNAs as potential novel and minimally invasive biomarkers for livestock species.

Title

Impact of the Genetic Background on the Composition of the Chicken Plasma MiRNome in Response to a Stress

Author

Marie-Laure Endale Ahanda,# 1 , 2 , 3 Tatiana Zerjal,# 1 , 2 , 3 Sophie Dhorne-Pollet, 1 , 2 , 3 Andrea Rau, 1 , 3 Amanda Cooksey, 4 , 5 and Elisabetta Giuffra 1 , 2 , 3 , *

Publish date

2014 Dec 4