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7,4’-Di-O-methylapigenin 5-O-xylosylglucoside

$930

  • Brand : BIOFRON

  • Catalogue Number : AV-B02128

  • Specification : 98%

  • CAS number : 221257-06-3

  • Formula : C28H32O14

  • Molecular Weight : 592.55

  • PUBCHEM ID : 21582635

  • Volume : 5mg

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Catalogue Number

AV-B02128

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

592.55

Appearance

Yellow powder

Botanical Source

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C=C3OC4C(C(C(C(O4)COC5C(C(C(CO5)O)O)O)O)O)O)OC

Synonyms

4H-1-Benzopyran-4-one, 7-methoxy-2-(4-methoxyphenyl)-5-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]-/7-Methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-5-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside

IUPAC Name

7-methoxy-2-(4-methoxyphenyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Density

1.6±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

290.1±27.8 °C

Boiling Point

878.9±65.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

ZTYIRUZJISZADH-AQLOEVPPSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:221257-06-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

23341773

Abstract

In oral squamous cell carcinoma (OSCC), metastasis to lymph nodes is associated with a 50% reduction in 5-year survival. To identify a metastatic gene set based on DNA copy number abnormalities (CNAs) of differentially expressed genes, we compared DNA and RNA of OSCC cells laser-microdissected from non-metastatic primary tumors (n?=?17) with those from lymph node metastases (n?=?20), using Affymetrix 250K Nsp single-nucleotide polymorphism (SNP) arrays and U133 Plus 2.0 arrays, respectively. With a false discovery rate (FDR)<5%, 1988 transcripts were found to be differentially expressed between primary and metastatic OSCC. Of these, 114 were found to have a significant correlation between DNA copy number and gene expression (FDR<0.01). Among these 114 correlated transcripts, the corresponding genomic regions of each of 95 transcripts had CNAs differences between primary and metastatic OSCC (FDR<0.01). Using an independent dataset of 133 patients, multivariable analysis showed that the OSCC-specific and overall mortality hazards ratio (HR) for patients carrying the 95-transcript signature were 4.75 (95% CI: 2.03-11.11) and 3.45 (95% CI: 1.84-6.50), respectively. To determine the degree by which these genes impact cell survival, we compared the growth of five OSCC cell lines before and after knockdown of over-amplified transcripts via a high-throughput siRNA-mediated screen. The expression-knockdown of 18 of the 26 genes tested showed a growth suppression ≥30% in at least one cell line (P<0.01). In particular, cell lines derived from late-stage OSCC were more sensitive to the knockdown of G3BP1 than cell lines derived from early-stage OSCC, and the growth suppression was likely caused by increase in apoptosis. Further investigation is warranted to examine the biological role of these genes in OSCC progression and their therapeutic potentials.

Title

Integrative Genomics in Combination with RNA Interference Identifies Prognostic and Functionally Relevant Gene Targets for Oral Squamous Cell Carcinoma

Author

Chang Xu, 1 , 2 Pei Wang, 3 , 4 Yan Liu, 3 Yuzheng Zhang, 3 Wenhong Fan, 3 Melissa P. Upton, 5 Pawadee Lohavanichbutr, 3 John R. Houck, 3 David R. Doody, 3 Neal D. Futran, 1 Lue Ping Zhao, 3 , 4 Stephen M. Schwartz, 3 , 6 Chu Chen, 1 , 3 , 6 and Eduardo Mendez 1 , 2 , 7 , *

Publish date

2013 Jan;


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