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7-Amino-4-(trifluoromethyl)coumarin

$320

  • Brand : BIOFRON

  • Catalogue Number : BN-O1466

  • Specification : 98%(HPLC)

  • CAS number : 53518-15-3

  • Formula : C10H6F3NO2

  • Molecular Weight : 229.15

  • PUBCHEM ID : 100641

  • Volume : 20mg

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Catalogue Number

BN-O1466

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

229.15

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC2=C(C=C1N)OC(=O)C=C2C(F)(F)F

Synonyms

7-Amino-4-(trifluoromethyl)-2H-chromen-2-one/2H-1-Benzopyran-2-one, 7-amino-4- (trifluoromethyl)-/7-amino-4-trifluoromethylchromen-2-one/Coumarin 151/7-NH2-4-CF3-coumarin/7-Amino-4-(trifluoromethyl)coumarin/7-amino-4-trifluoromethylcoumarin/7-amino-4-(trifluoromethyl)chromen-2-one/Coumarin 151,laser grade/2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)-

IUPAC Name

7-amino-4-(trifluoromethyl)chromen-2-one

Density

1.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

144.1±27.9 °C

Boiling Point

314.6±42.0 °C at 760 mmHg

Melting Point

221-222 °C(lit.)

InChl

InChl Key

JBNOVHJXQSHGRL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:53518-15-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

24867821

Abstract

The proteasome displays three distinct proteolytic activities. Currently, proteasome inhibitors are evaluated using specific fluorescent substrates for each of the individual active sites. However, the photophysical properties of the commonly used fluorophores are similar and thus, the simultaneous monitoring of the three proteolytic activities is not possible. We have developed a bimodal fluorescent fluorinated substrate as a novel tool to study the chymotrypsin-like (ChT-L) proteolytic activity and its regulation by inhibitors and by substrates of trypsin-like (T-L) and caspase-like sites (PA). We demonstrate that this substrate is reliable to evaluate the ChT-L inhibitory activity of new molecules either by fluorescence or (19)F NMR spectroscopy. We have found that the ChT-L activity is dramatically reduced in the presence of T-L and PA substrates. This work provides a proof of concept that the fluorinated substrate enables investigation of the allosteric regulation of the ChT-L activity.

Title

(19)F NMR Monitoring of the Eukaryotic 20S Proteasome Chymotrypsin-Like Activity: An Investigative Tool for Studying Allosteric Regulation

Author

M Keita 1, J Kaffy, C Troufflard, E Morvan, B Crousse, S Ongeri

Publish date

2014 Jul 14

PMID

7989615

Abstract

Treponema denticola (Td) and Porphyromonas gingivalis (Pg) are associated with human moderate and severe adult periodontal diseases. This study quantifies these two anaerobes and their trypsin-like (TL) activities in subgingival plaque collected from both clinically healthy and periodontally diseased sites of human periodontitis patients. Antigen levels of the microorganisms were determined by monoclonal antibodies and TL activities were measured by the fluorescent substrate Z-gly-gly-arg-AFC in a disc format. Significant positive correlations were observed between the antigen levels and the TL activities when the data were subjected to statistical analyses both on a site-specific and on a patient basis. Anaerobe synergism was found between Td and Pg in a continental US population, and positive correlations were found between anaerobe levels (individually and total) and clinical indicators of adult periodontitis.

Title

Trypsin-like Activity Levels of Treponema Denticola and Porphyromonas Gingivalis in Adults With Periodontitis

Author

E D Pederson 1, J W Miller, S Matheson, L G Simonson, D E Chadwick, P J Covill, D W Turner, B L Lamberts, H E Morton

Publish date

1994 Sep;

PMID

22564382

Abstract

A new self-immolative spacer conjugate based on a chemical adaptor unit aiming at controlled releasing drugs was designed and synthesized. It releases a fluorophore which was used as a model drug via a spontaneous cyclization mechanism after cleavage of an enzyme substrate. This system was proved to be stable under physiological conditions and only decomposed triggered by enzyme. It provides a generic linkage allowing connection of a variety of drugs and targeted devices to the chemical adaptor.

Copyright © 2012 Elsevier Ltd. All rights reserved.

Title

Development of a New Enzyme-Responsive Self-Immolative Spacer Conjugate Applicable to the Controlled Drug Release

Author

Hui-juan Jin 1, Jing Lu, Xue Wu

Publish date

2012 Jun 1


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