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7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

$58

  • Brand : BIOFRON

  • Catalogue Number : BN-O1033

  • Specification : 98%(HPLC)

  • CAS number : 160129-45-3

  • Formula : C10H10ClNO

  • Molecular Weight : 195.64

  • PUBCHEM ID : 22903483

  • Volume : 5mg

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Catalogue Number

BN-O1033

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

195.64

Appearance

Botanical Source

Structure Type

Category

SMILES

C1CC(=O)C2=C(C=CC(=C2)Cl)NC1

Synonyms

7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one/7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE/7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one/5H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-/7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one/7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE

IUPAC Name

7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one

Density

1.2±0.1 g/cm3

Solubility

Flash Point

169.4±27.6 °C

Boiling Point

356.5±41.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C19H22O2/c1-5-6-13-10-16(20)18-14-9-12(2)7-8-15(14)19(3,4)21-17(18)11-13/h7-11,20H,5-6H2,1-4H3

InChl Key

AHESNFIUAHTYGS-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:160129-45-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

17010212

Abstract

Background
The production of Citrus, the largest fruit crop of international economic value, has recently been imperiled due to the introduction of the bacterial disease Citrus canker. No significant improvements have been made to combat this disease by plant breeding and nuclear transgenic approaches. Chloroplast genetic engineering has a number of advantages over nuclear transformation; it not only increases transgene expression but also facilitates transgene containment, which is one of the major impediments for development of transgenic trees. We have sequenced the Citrus chloroplast genome to facilitate genetic improvement of this crop and to assess phylogenetic relationships among major lineages of angiosperms.

Results
The complete chloroplast genome sequence of Citrus sinensis is 160,129 bp in length, and contains 133 genes (89 protein-coding, 4 rRNAs and 30 distinct tRNAs). Genome organization is very similar to the inferred ancestral angiosperm chloroplast genome. However, in Citrus the infA gene is absent. The inverted repeat region has expanded to duplicate rps19 and the first 84 amino acids of rpl22. The rpl22 gene in the IRb region has a nonsense mutation resulting in 9 stop codons. This was confirmed by PCR amplification and sequencing using primers that flank the IR/LSC boundaries. Repeat analysis identified 29 direct and inverted repeats 30 bp or longer with a sequence identity ≥ 90%. Comparison of protein-coding sequences with expressed sequence tags revealed six putative RNA edits, five of which resulted in non-synonymous modifications in petL, psbH, ycf2 and ndhA. Phylogenetic analyses using maximum parsimony (MP) and maximum likelihood (ML) methods of a dataset composed of 61 protein-coding genes for 30 taxa provide strong support for the monophyly of several major clades of angiosperms, including monocots, eudicots, rosids and asterids. The MP and ML trees are incongruent in three areas: the position of Amborella and Nymphaeales, relationship of the magnoliid genus Calycanthus, and the monophyly of the eurosid I clade. Both MP and ML trees provide strong support for the monophyly of eurosids II and for the placement of Citrus (Sapindales) sister to a clade including the Malvales/Brassicales.

Conclusion
This is the first complete chloroplast genome sequence for a member of the Rutaceae and Sapindales. Expansion of the inverted repeat region to include rps19 and part of rpl22 and presence of two truncated copies of rpl22 is unusual among sequenced chloroplast genomes. Availability of a complete Citrus chloroplast genome sequence provides valuable information on intergenic spacer regions and endogenous regulatory sequences for chloroplast genetic engineering. Phylogenetic analyses resolve relationships among several major clades of angiosperms and provide strong support for the monophyly of the eurosid II clade and the position of the Sapindales sister to the Brassicales/Malvales.

Title

The complete chloroplast genome sequence of Citrus sinensis (L.) Osbeck var 'Ridge Pineapple': organization and phylogenetic relationships to other angiosperms

Author

Michael G Bausher,1 Nameirakpam D Singh,2 Seung-Bum Lee,2 Robert K Jansen,3 and Henry Daniellcorresponding author2

Publish date

2006;

PMID

30616694

Abstract

Porcine rotaviruses cause severe economic losses in the Korean swine industry due to G- and P-genotype mismatches between the predominant field and vaccine strains. Here, we developed a live attenuated trivalent porcine group A rotavirus vaccine using 80 cell culture passages of the representative Korean predominant strains G8P[7] 174-1, G9P[23] PRG942, and G5P[7] K71. Vaccination with the trivalent vaccine or its individual components induced no diarrhea during the first 2 weeks post-vaccination, i.e., the vaccines were attenuated. Challenge of trivalent-vaccinated or component-vaccinated piglets with homologous virulent strain(s) did not induce diarrhea for 2 weeks post-challenge. Immunization with the trivalent vaccine or its individual components also alleviated the histopathological lesions in the small intestines caused by challenge with the corresponding original virulent strain(s). Fecal secretory IgAs specific for each of vaccine strains were detected starting at 14 days post-vaccination (dpv), and IgA levels gradually increased up to 28 dpv. Oral immunization with the trivalent vaccine or its individual components induced high levels of serum virus-neutralizing antibody by 7 dpv. No diarrhea was observed in any experimental piglets during five consecutive passages of each vaccine strain. Our data indicated that the live attenuated trivalent vaccine was safe and effective at protecting piglets from diarrhea induced by challenge exposure of homologous virulent strains. This trivalent vaccine will potentially contribute toward controlling porcine rotavirus disease in South Korea and other countries where rotavirus infections with similar G and P genotypes are problematic.

Electronic supplementary material
The online version of this article (10.1186/s13567-018-0619-6) contains supplementary material, which is available to authorized users.

Title

Development of a live attenuated trivalent porcine rotavirus A vaccine against disease caused by recent strains most prevalent in South Korea

Author

Jun-Gyu Park,#1 Mia Madel Alfajaro,#1 Eun-Hyo Cho,1 Ji-Yun Kim,1 Mahmoud Soliman,1 Yeong-Bin Baek,1 Chul-Ho Park,2 Ju-Hwan Lee,2 Kyu-Yeol Son,1,3 Kyoung-Oh Cho,corresponding author1 and Mun-Il Kangcorresponding author

Publish date

2019;

PMID

31364317

Abstract

The recent emergence and re-emergence of porcine epidemic diarrhea virus (PEDV) underscore the urgent need for the development of novel, safe, and effective vaccines against the prevailing strain. In this study, we generated a cold-adapted live attenuated vaccine candidate (Aram-P29-CA) by short-term passage of a virulent PEDV isolate at successively lower temperatures in Vero cells. Whole genome sequencing identified 12 amino acid changes in the cold-adapted strain with no insertions and deletions throughout the genome. Animal inoculation experiments confirmed the attenuated phenotype of Aram-P29-CA virus in the natural host. Pregnant sows were orally administered P29-CA live vaccines two doses at 2-week intervals prior to parturition, and the newborn piglets were challenged with the parental virus. The oral homologous prime-boost vaccination of P29-CA significantly improved the survival rate of the piglets and notably mitigated the severity of diarrhea and PEDV fecal shedding after the challenge. Furthermore, strong antibody responses to PEDV were detected in the sera and colostrum of immunized sows and in the sera of their offspring. These results demonstrated that the cold-adapted attenuated virus can be used as a live vaccine in maternal vaccination strategies to provide durable lactogenic immunity and confer passive protection to litters against PEDV.

KEYWORDS

Attenuated vaccine, cold adaptation, porcine epidemic diarrhea virus, protection, whole genome sequencing

Title

Generation and protective efficacy of a cold-adapted attenuated genotype 2b porcine epidemic diarrhea virus

Author

Hokeun Won,1,2 Dong-Uk Lee,1 Guehwan Jang,3 Yun-Hee Noh,1 Seung-Chul Lee,1 Hwan-Won Choi,1 In-Joong Yoon,1 Han Sang Yoo,2 Changhee Leecorresponding author3

Publish date

2019 Jul;


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