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7-Demethylsuberosin

$165

  • Brand : BIOFRON

  • Catalogue Number : AV-H17074

  • Specification : 98%

  • CAS number : 21422-04-8

  • Formula : C14H14O3

  • Molecular Weight : 230.26

  • PUBCHEM ID : 5316525

  • Volume : 20mg

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Catalogue Number

AV-H17074

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

230.26

Appearance

Yellow crystalline powder

Botanical Source

Angelica gigas; Evodia lepta /Feronia limonia

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

CC(=CCC1=C(C=C2C(=C1)C=CC(=O)O2)O)C

Synonyms

7-demethylsuberosin/O-demethylsuberosin/Demethylsuberosin/2H-1-Benzopyran-2-one, 7-hydroxy-6-(3-methyl-2-buten-1-yl)-/7-Hydroxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-2-one/BEN267/2H-1-Benzopyran-2-one, 7-hydroxy-6-(3-methyl-2-butenyl)-/7-hydroxy-6-prenylcoumarin/7-demethylsuberosine

IUPAC Name

7-hydroxy-6-(3-methylbut-2-enyl)chromen-2-one

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

182.0±21.5 °C

Boiling Point

418.8±45.0 °C at 760 mmHg

Melting Point

134-136℃

InChl

InChI=1S/C14H14O3/c1-9(2)3-4-10-7-11-5-6-14(16)17-13(11)8-12(10)15/h3,5-8,15H,4H2,1-2H3

InChl Key

FIDUIAPDSKSUGO-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:21422-04-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

25090710

Abstract
OBJECTIVE: To study the chemical constituents of Pattra Medicine Euodia lepta in Xishuangbanna of Yunnan Province. METHODS: The chemical constituents were isolated and purified by chromatographic techniques, and identified by NMR, MS and other spectral methods. RESULTS: In 60% ethanol extract from the stems,and 95% ethanol extract from the leaves, six compounds and two compounds were isolated and identified as pachypodol( 1) ,3-(3-methyl-but-2-enyl )umbelliferone(2),7-demethylsuberosin (3),beta-sitosterol (4),3,7-dimethoxy kaempferol(5), euolitrine(6), sesamin(7) and p-O-geranyl coumaric acid(8), respectively. CONCLUSION: Compound 7 is obtained from Euodia genus for the first time,and compound 8 is obtained from domestic Euodia lepta for the first time.
Title

[Chemical constituents of pattra medicine Euodia lepta].

Author

Kang GJ, Yang SJ, Zhou HY, Yang ZM, Chen LY.

Publish date

2014 Jan

PMID

2828055

Abstract
Suspension cultures of Ammi majus L. cells produce various linear furanocoumarins in response to treatment with elicitor preparations from either Alternaria carthami Chowdhury or Phytophthora megasperma f.sp. glycinea. Microsomes which were isolated from these cells 14 h after addition of the elicitor efficiently catalyzed the conversion of demethyl [3-14C]suberosin into labelled (+)marmesin in the presence of NADPH and oxygen. In contrast to the chemical cyclization of demethylsuberosin by m-chloroperoxybenzoic acid, the reaction catalyzed by the marmesin synthase proceeded rapidly and no intermediate demethylsuberosin epoxide could be recovered. Significant blue-light-reversible inhibition by carbon monoxide and inhibition by various chemicals known to inhibit reactions dependent on cytochrome P450 suggested that the marmesin synthase is a cytochrome-P450-dependent monooxygenase. Upon prolonged incubation, a subsequent major labelled product originated from (+)marmesin, which was identified as psoralen. The psoralen synthase was also characterized as a cytochrome-P450-dependent monooxygenase. Both the marmesin synthase and the psoralen synthase, as well as enzymes catalyzing the formation of demethylsuberosin and O-prenylumbelliferone from umbelliferone and dimethylallyl diphosphate, were associated with the endoplasmic reticulum in Ammi majus cells and their activities were concomitantly induced by elicitor treatment of the cells. We propose that in vivo these enzymes are active in the lumen of the endoplasmic reticulum from where the furanocoumarin phytoalexins are excreted into the cell culture fluid.
Title

Elicitor-induced biosynthesis of psoralens in Ammi majus L. suspension cultures. Microsomal conversion of demethylsuberosin into (+)marmesin and psoralen.

Author

Hamerski D1, Matern U.

Publish date

1988 Jan 15

PMID

7252783

Title

[Studies on constituents of Angelicae dahuricae Radix. I. On a new furocoumarin derivative (author's transl)].

Author

Fujiwara H, Yokoi T, Tani S, Saiki Y, Kato A.

Publish date

1980 Dec;


Description :

Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound isolated from Angelica gigas Nakai, and has anti-inflammatory activity[1].