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  • Brand : BIOFRON

  • Catalogue Number : BN-O1600

  • Specification : 98%(HPLC)

  • CAS number : 100079-34-3

  • Formula : C18H18O6

  • Molecular Weight : 330.3

  • PUBCHEM ID : 21636238

  • Volume : 5mg

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Catalogue Number


Analysis Method





Molecular Weight




Botanical Source

This product is isolated and purified from the herb of Scutellaria barbata

Structure Type





7-Hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one/4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-, (2S)-/(2S)-7-Hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one/4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-



1.3±0.1 g/cm3


Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

202.8±23.6 °C

Boiling Point

552.9±50.0 °C at 760 mmHg

Melting Point


InChl Key


WGK Germany


HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:100079-34-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




To evaluate a new a cut off level of fetal fibronectin as a predictor of birth in women with threatened preterm labour.

A retrospective cohort study performed at Ipswich hospital, Ipswich, Queensland, Australia, in women with threatened preterm labour with intact membranes between 23 weeks to 34 + 6 week gestation.

Study design
A quantitative fetal fibronectin (fFN) was performed. Maternal demographics and birth outcome data were extracted from the routinely collected perinatal data held by the hospital. The odds of preterm birth were estimated for each cut off value of fFN (10, 50 and 200 ng ml−1) using logistic regression and accounting for multiple presentations by the same woman.

Among the 447 presentations and 376 pregnancies, rates of preterm birth <34 weeks were 2.9%, 9.2%, 3.3%, 19.6%, 4.2% and 35.3% for each category of values respectively (fFN <10, ≥10, <50, ≥50, <200 and ≥200 ng ml−1). Birth rates within 7 d of testing were 1.1%, 7.5%, 1.8%, 16.1%, 2.1% and 41.2% respectively. Comparing fFN level of <10 to a level of 10-199 ng ml−1 there was no significant increase in odds of preterm birth < 34 weeks or birth within the next 7 d (OR 2.28, 95% CI 0.84-6.17 and OR 3.61, 95% CI 0.89-14.7 respectively. Conclusion In women presenting with TPL, those with levels of <200 ng ml−1 have a low risk of birthing within 7 d or before 34 weeks gestation. This allows a personalised decision making and probable discharge home without need for steroid loading.


Threatened preterm labour, Quantitative fetal fibronectin, Prediction


Predictive value of the quantitative fetal fibronectin levels for the management of women presenting with threatened preterm labour - A revised cut off level: A retrospective cohort study


Kassam Mahomed,a,⁎ Ibinabo Ibiebele,b Christine Fraser,c and Consuela Brownc

Publish date

2019 Oct; 4:




In the last decade, the consumption trend of organic food has increased dramatically worldwide. Since only a few pesticides are authorized in organic crops, concentrations are expected to range at zero or ultra-trace levels. In this context, the aim of the present study was to investigate the need for an improvement in the residue controls at very low concentrations (<0.010 mg kg−1) and to assess the impact of the scope of the analytical methods for this type of crops. For that purpose, a monitoring study for fruit and vegetable samples covering a wide range of pesticides (3 2 8) at low LOQs (0.002-0.005 mg kg−1) was developed. The results showed that the impact of applying analytical methods with low LOQs was not very relevant in the majority of the cases. However, a wide scope presented a high influence on this evaluation, especially regarding the inclusion of very polar compounds and metabolites.


Authorized pesticides, Ionic polar compounds, Organic food, GC-MS/MS, LC-MS/MS, IC-Q-Orbitrap-MS/MS


Pesticide residues evaluation of organic crops. A critical appraisal


Maria del Mar Gomez-Ramos,a,b Christina Nannou,c Maria Jesús Martinez Bueno,b Ana Goday,b Maria Murcia-Morales,b Carmen Ferrer,b and Amadeo R. Fernandez-Albab,⁎

Publish date

2020 Mar 30




O6-alkylguanine-DNA alkyltransferase (AGT) is the main cause of tumor cell resistance to DNA-alkylating agents, so it is valuable to design tumor-targeted AGT inhibitors with hypoxia activation. Based on the existing benchmark inhibitor O6-benzylguanine (O6-BG), four derivatives with hypoxia-reduced potential and their corresponding reduction products were synthesized. A reductase system consisting of glucose/glucose oxidase, xanthine/xanthine oxidase, and catalase were constructed, and the reduction products of the hypoxia-activated prodrugs under normoxic and hypoxic conditions were determined by high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). The results showed that the reduction products produced under hypoxic conditions were significantly higher than that under normoxic condition. The amount of the reduction product yielded from ANBP (2-nitro-6-(3-amino) benzyloxypurine) under hypoxic conditions was the highest, followed by AMNBP (2-nitro-6-(3-aminomethyl)benzyloxypurine), 2-NBP (2-nitro-6-benzyloxypurine), and 3-NBG (O6-(3-nitro)benzylguanine). It should be noted that although the levels of the reduction products of 2-NBP and 3-NBG were lower than those of ANBP and AMNBP, their maximal hypoxic/normoxic ratios were higher than those of the other two prodrugs. Meanwhile, we also investigated the single electron reduction mechanism of the hypoxia-activated prodrugs using density functional theory (DFT) calculations. As a result, the reduction of the nitro group to the nitroso was proven to be a rate-limiting step. Moreover, the 2-nitro group of purine ring was more ready to be reduced than the 3-nitro group of benzyl. The energy barriers of the rate-limiting steps were 34-37 kcal/mol. The interactions between these prodrugs and nitroreductase were explored via molecular docking study, and ANBP was observed to have the highest affinity to nitroreductase, followed by AMNBP, 2-NBP, and 3-NBG. Interestingly, the theoretical results were generally in a good agreement with the experimental results. Finally, molecular docking and molecular dynamics simulations were performed to predict the AGT-inhibitory activity of the four prodrugs and their reduction products. In summary, simultaneous consideration of reduction potential and hypoxic selectivity is necessary to ensure that such prodrugs have good hypoxic tumor targeting. This study provides insights into the hypoxia-activated mechanism of nitro-substituted prodrugs as AGT inhibitors, which may contribute to reasonable design and development of novel tumor-targeted AGT inhibitors.


hypoxia-activated AGT inhibitors, reduction of nitro group, density functional theory, HPLC-ESI-MS/MS, molecular docking, tumor targeting


Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation


Weinan Xiao,1 Guohui Sun,1 Tengjiao Fan,1,2 Junjun Liu,1 Na Zhang,1 Lijiao Zhao,1,* and Rugang Zhong1

Publish date

2019 Dec

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