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7-Prenyloxycoumarin

$224

  • Brand : BIOFRON

  • Catalogue Number : BD-P0838

  • Specification : 98.0%(HPLC)

  • CAS number : 10387-50-5

  • Formula : C14H14O3

  • Molecular Weight : 230.3

  • PUBCHEM ID : 320362

  • Volume : 25mg

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Catalogue Number

BD-P0838

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

230.3

Appearance

Powder

Botanical Source

Structure Type

Coumarins

Category

SMILES

CC(=CCOC1=CC2=C(C=C1)C=CC(=O)O2)C

Synonyms

7-(3-methylbut-2-enoxy)chromen-2-one

IUPAC Name

7-(3-methylbut-2-enoxy)chromen-2-one

Applications

Density

1.148g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

164.9ºC

Boiling Point

390.9ºC at 760mmHg

Melting Point

InChl

InChI=1S/C14H14O3/c1-10(2)7-8-16-12-5-3-11-4-6-14(15)17-13(11)9-12/h3-7,9H,8H2,1-2H3

InChl Key

SMHJTSOVVRGDEO-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:10387-50-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30224905

Abstract

Hormesis is a new concept in dose-response relationship. Despite of traditional dose-response curves, there is a low-dose stimulation and a high-dose inhibition in this case. Hormesis effect in apoptosis induction/inhibition by natural compounds is reported previously. Here, we searched this effect for myeloid cell leukemia type-1 (Mcl-1) gene expression by phytochemicals 7-isopenthenyloxycoumarin (7-IP), arctigenin (Arg), and hesperidin (Hsp). For this purpose, first we tested the cytotoxicity of various doses of these compounds against K562 leukemia cell lines for different times by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. After that we explored the effect of various doses of these phytochemicals on Mcl-1 gene expression for different times by real-time polymerase chain reaction method. We found that these phytochemicals have cytotoxicity against K562 cell line. Hesperidin is the most cytotoxic agent. We also found that these natural compounds have hormetic effect on Mcl-1 gene expression. The hormetic model in Mcl-1 gene expression is overcompensation stimulation. This phenomenon is reported for the first time. We conclude that 7-IP, Arg, and Hsp are cytotoxic against K562 cancerous cells and induce/inhibit Mcl-1 gene expression by hormesis dose-response relationship.

KEYWORDS

7-isopenthenyloxycoumarin, arctigenin, hesperidin, myeloid cell leukemia type-1 (Mcl-1), hormesis

Title

7-Isopenthenyloxycoumarin, Arctigenin, and Hesperidin Modify Myeloid Cell Leukemia Type-1 (Mcl-1) Gene Expression by Hormesis in K562 Cell Line

Author

Zahra Kafi,1 Hamid Cheshomi,1,2 and Omid Gholami1

Publish date

2018 Jul-Sep;