7,2'-Dihydroxy-3',4'-dimethoxyisoflavan

Description

Catalogue Number

AV-H17090

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

302.32

Appearance

Powder

Botanical Source

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C(=C(C=C1)C2CC3=C(C=C(C=C3)O)OC2)O)OC

Synonyms

2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(2-hydroxy-3,4-dimethoxyphenyl)-/7,2'-Dihydroxy-3',4'-dimethoxyisoflavan/3-(2-Hydroxy-3,4-dimethoxyphenyl)-7-chromanol/2H-1-Benzopyran-7-ol,3,4-dihydro-3-(2-hydroxy-3,4-dimethoxyphenyl)

IUPAC Name

3-(2-hydroxy-3,4-dimethoxyphenyl)-3,4-dihydro-2H-chromen-7-ol

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

211.9±28.7 °C

Boiling Point

426.8±45.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C17H18O5/c1-20-14-6-5-13(16(19)17(14)21-2)11-7-10-3-4-12(18)8-15(10)22-9-11/h3-6,8,11,18-19H,7,9H2,1-2H3

InChl Key

NQRBAPDEZYMKFL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:52250-35-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

Documents

No Technical Documents Available For This Product.

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Articles

Article 1

PMID

20004765

Abstract

Mental retardation/intellectual disability is a devastating neurodevelopmental disorder with serious impact on affected individuals and their families, as well as on health and social services. It occurs with a prevalence of ∼2%, is an etiologically heterogeneous condition, and is frequently the result of genetic aberrations. Autosomal-recessive forms of nonsyndromic MR (NS-ARMR) are believed to be common, yet only five genes have been identified. We have used homozygosity mapping to search for the gene responsible for NS-ARMR in a large Pakistani pedigree. Using Affymetrix 5.0 single nucleotide polymorphism (SNP) microarrays, we identified a 3.2 Mb region on 8q24 with a continuous run of 606 homozygous SNPs shared among all affected members of the family. Additional genotype data from microsatellite markers verified this, allowing us to calculate a two-point LOD score of 5.18. Within this region, we identified a truncating homozygous mutation, R475X, in exon 7 of the gene TRAPPC9. In a second large NS-ARMR/ID family, previously linked to 8q24 in a study of Iranian families, we identified a 4 bp deletion within exon 14 of TRAPPC9, also segregating with the phenotype and truncating the protein. This gene encodes NIK- and IKK-β-binding protein (NIBP), which is involved in the NF-κB signaling pathway and directly interacts with IKK-β and MAP3K14. Brain magnetic resonance imaging of affected individuals indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals. Thus, to our knowledge, this is the sixth gene for NS-ARMR to be discovered.

Title

Identification of Mutations in TRAPPC9, which Encodes the NIK- and IKK-β-Binding Protein, in Nonsyndromic Autosomal-Recessive Mental Retardation

Author

Asif Mir,1,16 Liana Kaufman,2,16 Abdul Noor,2 Mahdi M. Motazacker,3 Talal Jamil,1 Matloob Azam,4 Kimia Kahrizi,5 Muhammad Arshad Rafiq,2 Rosanna Weksberg,6 Tanveer Nasr,7,8 Farooq Naeem,9,10 Andreas Tzschach,3 Andreas W. Kuss,3 Gisele E. Ishak,11 Dan Doherty,12 H. Hilger Ropers,3 A. James Barkovich,13 Hossein Najmabadi,5 Muhammad Ayub,7,14 and John B. Vincent2,15,?

Publish date

2009 Dec 11;

Article 2

PMID

31438505

Abstract

Sagittaria trifolia is a medicinal foodstuff of China and East Asia belonging to the family Alismataceae. Samples of S. trifolia tubers were collected from Meihekow, Siping, Jilin, Harbin and Wuchang from Northeast China. The current study was aimed to evaluate the qualitative and quantitative analysis, antioxidant activity, biochemical analysis and chemical composition of different populations of S. trifolia. By using Folin-Ciocalteu, aluminium chloride colourimetric and 1,1-diphenyl-1-picrylhydrazyl (DPPH), total phenol and flavonoids content and antioxidant activity was analysed. Furthermore, chemical composition, biochemical analysis and mineral substances were also determined. The results showed the presence of flavonoids, phenols, saponins, tannins, glycosides and steroids except for alkaloids and terpenoids by qualitative analysis. Quantitative analysis revealed that highest total phenol, flavonoids content and antioxidant potential identified from Meihekow, i.e., 2.307 mg GAE/g, 12.263 mg QE/g and 77.373%, respectively. Gas chromatography-mass spectrometry results showed the presence of 40 chemical compounds corresponding to 99.44% of total extract that might be responsible for antioxidant properties. Mineral and biochemical analysis revealed the presence of calcium, magnesium, potassium, sodium, iron, copper, zinc and, carbohydrate, protein, fibre and fat contents, respectively. Interestingly, all S. trifolia populations collected from different locations possess similar composition. The dietary values, phytoconstituents, antioxidant activities and nutritional and curative chemical compounds of S. trifolia are beneficial for the nutritherapy of human beings.

KEYWORDS

Sagittaria trifolia, phytochemicals, phenol and flavonoids content, DPPH, biochemical composition

Title

Phytochemical Analysis, Biochemical and Mineral Composition and GC-MS Profiling of Methanolic Extract of Chinese Arrowhead Sagittaria trifolia L. from Northeast China

Author

Maqsood Ahmed,1 Mingshan Ji,1,* Aatika Sikandar,1 Aafia Iram,2 Peiwen Qin,1 He Zhu,1 Ansar Javeed,3 Jamil Shafi,4 Zeeshan Iqbal,5 Mazher Farid Iqbal,3 and Zhonghua Sun1

Publish date

2019 Sep;

Article 3

PMID

25701870

Abstract

There are two known mRNA degradation pathways, 3′ to 5′ and 5′ to 3′. We identified likely pathogenic variants in two genes involved in these two pathways in individuals with intellectual disability. In a large family with multiple branches, we identified biallelic variants in DCPS in three affected individuals; a splice site variant (c.636+1G>A) that results in an in-frame insertion of 45 nucleotides and a missense variant (c.947C>T; p.Thr316Met). DCPS decaps the cap structure generated by 3′ to 5′ exonucleolytic degradation of mRNA. In vitro decapping assays showed an ablation of decapping function for both variants in DCPS. In another family, we identified a homozygous mutation (c.161T>C; p.Phe54Ser) in EDC3 in two affected children. EDC3 stimulates DCP2, which decaps mRNAs at the beginning of the 5′ to 3′ degradation pathway. In vitro decapping assays showed that altered EDC3 is unable to enhance DCP2 decapping at low concentrations and even inhibits DCP2 decapping at high concentration. We show that individuals with biallelic mutations in these genes of seemingly central functions are viable and that these possibly lead to impairment of neurological functions linking mRNA decapping to normal cognition. Our results further affirm an emerging theme linking aberrant mRNA metabolism to neurological defects.

Title

Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment

Author

Iltaf Ahmed,1,2,† Rebecca Buchert,3,† Mi Zhou,5,† Xinfu Jiao,5,† Kirti Mittal,1 Taimoor I. Sheikh,1 Ute Scheller,3 Nasim Vasli,1 Muhammad Arshad Rafiq,1 M. Qasim Brohi,6 Anna Mikhailov,1 Muhammad Ayaz,7 Attya Bhatti,2 Heinrich Sticht,4 Tanveer Nasr,8,9 Melissa T. Carter,10 Steffen Uebe,3 Andre Reis,3 Muhammad Ayub,7,11 Peter John,2 Megerditch Kiledjian,5,* John B. Vincent,1,12,13,* and Rami Abou Jamra3,*

Publish date

2015 Jun 1

7,2′-Dihydroxy-3′,4′-dimethoxyisoflavan

$570

Description :