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8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione

$72

  • Brand : BIOFRON

  • Catalogue Number : BN-O1202

  • Specification : 98%(HPLC)

  • CAS number : 666816-98-4

  • Formula : C10H9BrN4O2

  • Molecular Weight : 297.11

  • PUBCHEM ID : 21088927

  • Volume : 5mg

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Catalogue Number

BN-O1202

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

297.11

Appearance

Botanical Source

Structure Type

Category

SMILES

CC#CCN1C2=C(N=C1Br)N(C(=O)NC2=O)C

Synonyms

8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione/8-Bromo-7-(2-butyn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione/8-Bromo-7-(but-2-ynyl)-3-methyl-3,7-dihydropurine-2,6-dione/8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione/1H-Purine-2,6-dione, 8-bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-/8-bromo-7-but-2-ynyl-3-methylpurine-2,6-dione/T56 BN DN FNVMVJ B2UU2 CE F1/8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione/8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

IUPAC Name

8-bromo-7-but-2-ynyl-3-methylpurine-2,6-dione

Density

1.7±0.1 g/cm3

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

HFZOBQSHTNNKFY-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:666816-98-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28369610

Abstract

Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome resolution and/or adaptation are not well understood. Here, we examine hybrid genome evolution using experimental evolution of de novo interspecific hybrid yeast Saccharomyces cerevisiae × Saccharomyces uvarum and their parentals. We evolved these strains in nutrient-limited conditions for hundreds of generations and sequenced the resulting cultures identifying numerous point mutations, copy number changes, and loss of heterozygosity (LOH) events, including species-biased amplification of nutrient transporters. We focused on a particularly interesting example, in which we saw repeated LOH at the high-affinity phosphate transporter gene PHO84 in both intra- and interspecific hybrids. Using allele replacement methods, we tested the fitness of different alleles in hybrid and S. cerevisiae strain backgrounds and found that the LOH is indeed the result of selection on one allele over the other in both S. cerevisiae and the hybrids. This is an example where hybrid genome resolution is driven by positive selection on existing heterozygosity and demonstrates that even infrequent outcrossing may have lasting impacts on adaptation.

KEYWORDS

hybrid, adaptation, loss of heterozygosity, experimental evolution, Saccharomyces uvarum, Saccharomyces cerevisiae

Title

Loss of Heterozygosity Drives Adaptation in Hybrid Yeast

Author

Caiti S. Smukowski Heil,1 Christopher G. DeSevo,2 Dave A. Pai,2 Cheryl M. Tucker,2 Margaret L. Hoang,3,4 and Maitreya J. Dunhamcorresponding author1

Publish date

2017 Jul;


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