Catalogue Number
BN-O1202
Analysis Method
Specification
98%(HPLC)
Storage
2-8°C
Molecular Weight
297.11
Appearance
Botanical Source
Structure Type
Category
SMILES
CC#CCN1C2=C(N=C1Br)N(C(=O)NC2=O)C
Synonyms
8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione/8-Bromo-7-(2-butyn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione/8-Bromo-7-(but-2-ynyl)-3-methyl-3,7-dihydropurine-2,6-dione/8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione/1H-Purine-2,6-dione, 8-bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-/8-bromo-7-but-2-ynyl-3-methylpurine-2,6-dione/T56 BN DN FNVMVJ B2UU2 CE F1/8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione/8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
IUPAC Name
8-bromo-7-but-2-ynyl-3-methylpurine-2,6-dione
Density
1.7±0.1 g/cm3
Solubility
Flash Point
Boiling Point
Melting Point
InChl
InChl Key
HFZOBQSHTNNKFY-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:666816-98-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
28369610
Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome resolution and/or adaptation are not well understood. Here, we examine hybrid genome evolution using experimental evolution of de novo interspecific hybrid yeast Saccharomyces cerevisiae × Saccharomyces uvarum and their parentals. We evolved these strains in nutrient-limited conditions for hundreds of generations and sequenced the resulting cultures identifying numerous point mutations, copy number changes, and loss of heterozygosity (LOH) events, including species-biased amplification of nutrient transporters. We focused on a particularly interesting example, in which we saw repeated LOH at the high-affinity phosphate transporter gene PHO84 in both intra- and interspecific hybrids. Using allele replacement methods, we tested the fitness of different alleles in hybrid and S. cerevisiae strain backgrounds and found that the LOH is indeed the result of selection on one allele over the other in both S. cerevisiae and the hybrids. This is an example where hybrid genome resolution is driven by positive selection on existing heterozygosity and demonstrates that even infrequent outcrossing may have lasting impacts on adaptation.
hybrid, adaptation, loss of heterozygosity, experimental evolution, Saccharomyces uvarum, Saccharomyces cerevisiae
Loss of Heterozygosity Drives Adaptation in Hybrid Yeast
Caiti S. Smukowski Heil,1 Christopher G. DeSevo,2 Dave A. Pai,2 Cheryl M. Tucker,2 Margaret L. Hoang,3,4 and Maitreya J. Dunhamcorresponding author1
2017 Jul;
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