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9-(1H-Benzotriazol-1-ylmethyl)-9H-carbazole

$77

  • Brand : BIOFRON

  • Catalogue Number : BN-O1140

  • Specification : 98%(HPLC)

  • CAS number : 124337-34-4

  • Formula : C19H14N4

  • Molecular Weight : 298.3

  • PUBCHEM ID : 4519736

  • Volume : 5mg

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Catalogue Number

BN-O1140

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

298.3

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C2C(=C1)C3=CC=CC=C3N2CN4C5=CC=CC=C5N=N4

Synonyms

9-(1H-Benzotriazol-1-ylmethyl)-9H-carbazole/9H-Carbazole, 9-(1H-1,2,3-benzotriazol-1-ylmethyl)-/9-(benzotriazol-1-ylmethyl)carbazole/9-benzotriazole-1-ylmethyl-9H-carbazole

IUPAC Name

9-(benzotriazol-1-ylmethyl)carbazole

Density

1.3±0.1 g/cm3

Solubility

Flash Point

243.9±26.5 °C

Boiling Point

479.8±37.0 °C at 760 mmHg

Melting Point

190-193ºC(lit.)

InChl

InChl Key

JWLQIMHJRKCIFA-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:124337-34-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

20447255

Abstract

Aim
The goal of this study is to characterize the changes in 33 biomarkers within the gingival crevicular fluid during the 3-week induction and 4-week resolution of stent-induced, biofilm overgrowth mediated, experimental gingivitis in humans.

Methods
Experimental gingivitis was induced in 25 subjects for 21 days followed by treatment with a sonic powered toothbrush for 28 days. Clinical indices and gingival crevicular fluids were collected weekly during induction and biweekly during resolution. Samples were analyzed using a bead-based multiplexing analysis for the simultaneous measurements of 33 biomarkers within each sample including cytokines, matrix-metalloproteinases and adipokines. Prostaglandin-E2 was measured by enzyme-linked immunoadsorbant assay. Statistical testing using general linear models with structured covariance matrices were performed to compare stent to contralateral (non-stent) changes in clinical signs and in biomarker levels over time.

Results
Gingivitis induction was associated with a significant 2.6-fold increase in interleukin 1-beta, a 3.1 fold increase in interleukin 1-alpha, and a significant decrease in multiple chemokines as well as matrixmetalloproteinases −1, −3 and 13. All changes in clinical signs and mediators rebounded to baseline in response to treatmentin the resolution phase.

Conclusions
Stent-induced gingivitis is associated with marked, but reversible increases in interleukins 1-alpha and 1-beta with suppression of multiple chemokines as well as selected matrixmetalloproteinases.

KEYWORDS

Periodontal disease, gingivitis, Inflammation, crevicular fluid, biofilm

Title

Changes in Gingival Crevicular Fluid Inflammatory Mediator Levels during the Induction and Resolution of Experimental Gingivitis in Humans

Author

Steven Offenbacher, DDs, PhD, MMSC,1 Silvana Barros, DDS, PhD,1 L Mendoza, DDS, S Mauriello, MS, J Preisser, PhD, K Moss, Marko de Jager, PhD, MMSc,2 and Marcelo Aspiras, PhD2

Publish date

2011 Apr 1.

PMID

30618515

Abstract

Background
As of 2011, among 250 administrative districts in Korea, 54 districts did not have obstetrics and gynecology clinics or hospitals providing prenatal care and delivery services. The Korean government designated 38 regions among 54 districts as “Obstetric Care Underserved Areas (OCUA).” However, little is known there are any differences in pregnancy, prenatal care, and outcomes of women dwelling in OCUA compared to women in other areas. The purposes of this study were to compare the pregnancy related indicators (PRIs) and adequacy of prenatal care between OCUA region and non-OCUA region.

Methods
Using National Health Insurance database in Korea from January 1, 2012 to December 31, 2014, we constructed the whole dataset of women who terminated pregnancy including delivery and abortion. We assessed incidence rate of 17 PRIs and adequacy of prenatal care. All indicators were compared between OCUA group and non-OCUA group.

Results
The women dwelling in OCUA regions were more likely to get abortion (4.6% in OCUA vs. 3.6% in non-OCUA) and receive inadequate prenatal care (7.2% vs. 4.4%). Regarding abortion rate, there were significant regional differences in abortion rate. The highest abortion rate was 10.3% and the lowest region was 1.2%. Among 38 OCUA regions, 29 regions’ abortion rates were higher than the national average of abortion rate (3.56%) and there were 10 regions in which abortion rates were higher than 7.0%. In addition, some PRIs such as acute pyelonephritis and transfusion in obstetric hemorrhage were more worse in OCUA regions compared to non-OCUA regions.

Conclusion
PRIs are different according to the regions where women are living. The Korean government should make an effort reducing these gaps of obstetric cares between OCUA and non-OCUA.

KEYWORDS

Medically Underserved Area, Rural Area, Abortion, Prenatal Care, Preterm Delivery, National Health Insurance

Title

Accessibility of Prenatal Care Can Affect Inequitable Health Outcomes of Pregnant Women Living in Obstetric Care Underserved Areas: a Nationwide Population-Based Study

Author

Mi Young Kwak,1,* Seung Mi Lee,2,* Tae Ho Lee,1 Sang Jun Eun,3 Jin Yong Lee,corresponding author4,5 and Yoon Kim5,6

Publish date

2019 Jan 7

PMID

23577182

Abstract

Background
Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of patients with autonomous cortisol secretion have insulin resistance. Cortisol excess is known to cause insulin resistance, an independent cardiovascular risk marker, however in patients with adrenal incidentalomas it is unknown whether their insulin resistance is secondary to the excess cortisol and therefore potentially reversible. In a proof of concept study we examined the short-term effects of glucocorticoid receptor (GR) antagonism in patients with an adrenal incidentaloma to determine whether their insulin resistance was reversible.

Methodology/Principal Findings
In a prospective open-label pilot study, six individuals with adrenal incidentalomas and autonomous cortisol secretion were treated with mifepristone (a GR antagonist) 200 mg twice daily and studied for 4 weeks on a Clinical Research Facility. Insulin resistance at four weeks was assessed by insulin resistance indices, lnHOMA-IR and lnMatsuda, and AUC insulin during a 2-hour glucose tolerance test. Biochemical evidence of GR blockade was shown in all individuals and across the group there was a significant reduction in insulin resistance: lnHOMA-IR (1.0vs0.6; p = 0.03), lnHOMA-%beta (4.8vs4.3; p = 0.03) and lnMatsuda (1.2vs1.6; p = 0.03). Five out of six individuals showed a reduction in insulin AUC >7237 pmol/l.min, and in two patients this showed a clinically significant cardiovascular benefit (as defined by the Helsinki heart study).

Conclusions
Short-term GR antagonism is sufficient to reduce insulin resistance in some individuals with adrenal incidentalomas and mild cortisol excess. Further assessment is required to assess if the responses may be used to stratify therapy as adrenal incidentalomas may be a common remediable cause of increased cardiovascular risk.

Trial Registration
ClinicalTrials.gov NCT00721201

Title

Mifepristone Reduces Insulin Resistance in Patient Volunteers with Adrenal Incidentalomas That Secrete Low Levels of Cortisol: A Pilot Study

Author

Miguel Debono, 1 Rita Chadarevian, 3 Richard Eastell, 2 Richard J. Ross, 1 and John Newell-Price 1 , * Harpal Singh Randeva, Editor

Publish date

2013;


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