We Offer Worldwide Shipping
Login Wishlist

9-Benzoylcarbazole

$106

  • Brand : BIOFRON

  • Catalogue Number : BN-O1142

  • Specification : 98%(HPLC)

  • CAS number : 19264-68-7

  • Formula : C19H13NO

  • Molecular Weight : 271.3

  • PUBCHEM ID : 95052

  • Volume : 5mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O1142

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

271.3

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3C4=CC=CC=C42

Synonyms

9-benzoylcarbazole/N-benzoylcarbazole/9H-Carbazol-9-yl(phenyl)methanone/(9H-carbazol-9-yl)(phenyl)methanone/Methanone, 9H-carbazol-9-ylphenyl-/9H-Carbazole,9-benzoyl/9-benzoyl-9H-carbazole/Carbazole,9-benzoyl/N-benzoyl-9H-carbazole/9-(phenylcarbonyl)carbazole

IUPAC Name

carbazol-9-yl(phenyl)methanone

Density

1.2±0.1 g/cm3

Solubility

Flash Point

190.4±20.4 °C

Boiling Point

391.2±15.0 °C at 760 mmHg

Melting Point

101ºC

InChl

InChl Key

BUCKMWPLVBYQCQ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19264-68-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27863209

Abstract

While the aging process is central to the pathogenesis of age-dependent diseases, it is poorly understood at the molecular level. We identified a mouse mutant with accelerated aging in the retina as well as pathologies observed in age-dependent retinal diseases, suggesting that the responsible gene regulates retinal aging, and its impairment results in age-dependent disease. We determined that a mutation in the transmembrane 135 (Tmem135) is responsible for these phenotypes. We observed localization of TMEM135 on mitochondria, and imbalance of mitochondrial fission and fusion in mutant Tmem135 as well as Tmem135 overexpressing cells, indicating that TMEM135 is involved in the regulation of mitochondrial dynamics. Additionally, mutant retina showed higher sensitivity to oxidative stress. These results suggest that the regulation of mitochondrial dynamics through TMEM135 is critical for protection from environmental stress and controlling the progression of retinal aging. Our study identified TMEM135 as a critical link between aging and age-dependent diseases.

DOI: http://dx.doi.org/10.7554/eLife.19264.001

Research Organism: Mouse

Title

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

Author

Wei-Hua Lee,1 Hitoshi Higuchi,1† Sakae Ikeda,1,2 Erica L Macke,1 Tetsuya Takimoto,1 Bikash R Pattnaik,2,3 Che Liu,4,5 Li-Fang Chu,6 Sandra M Siepka,7‡ Kathleen J Krentz,8 C Dustin Rubinstein,9 Robert F Kalejta,4,5 James A Thomson,6 Robert F Mullins,10 Joseph S Takahashi,11 Lawrence H Pinto,7 and Akihiro Ikeda1,2,*

Publish date

2016

PMID

22084084

Abstract

Pancreatic β-cells are an essential source of insulin and their destruction because of autoimmunity causes type I diabetes. We conducted a chemical screen to identify compounds that would induce the differentiation of insulin-producing β-cells in vivo. To do this screen, we brought together the use of transgenic zebrafish as a model of β-cell differentiation, a unique multiwell plate that allows easy visualization of lateral views of swimming larval fish and a library of clinical drugs. We identified six hits that can induce precocious differentiation of secondary islets in larval zebrafish. Three of these six hits were known drugs with a considerable background of published data on mechanism of action. Using pharmacological approaches, we have identified and characterized two unique pathways in β-cell differentiation in the zebrafish, including down-regulation of GTP production and retinoic acid biosynthesis.

KEYWORDS

progenitor, Notch-signaling, development, embryogenesis

Title

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation

Author

Meritxell Rovira,a,1 Wei Huang,a,1 Shamila Yusuff,a,1 Joong Sup Shim,b Anthony A. Ferrante,c Jun O. Liu,b,d and Michael J. Parsonsa,e,2

Publish date

2011 Nov 29;

PMID

24550721

Abstract

As scientific advances in perturbing biological systems and technological advances in data acquisition allow the large-scale quantitative analysis of biological function, the robustness of organisms to both transient environmental stresses and inter-generational genetic changes is a fundamental impediment to the identifiability of mathematical models of these functions. An approach to overcoming this impediment is to reduce the space of possible models to take into account both types of robustness. However, the relationship between the two is still controversial. This work uncovers a network characteristic, transient responsiveness, for a specific function that correlates environmental imperturbability and genetic robustness. We test this characteristic extensively for dynamic networks of ordinary differential equations ranging up to 30 interacting nodes and find that there is a power-law relating environmental imperturbability and genetic robustness that tends to linearity as the number of nodes increases. Using our methods, we refine the classification of known 3-node motifs in terms of their environmental and genetic robustness. We demonstrate our approach by applying it to the chemotaxis signaling network. In particular, we investigate plausible models for the role of CheV protein in biochemical adaptation via a phosphorylation pathway, testing modifications that could improve the robustness of the system to environmental and/or genetic perturbation.

Title

A Network Characteristic That Correlates Environmental and Genetic Robustness

Author

Zeina Shreif and Vipul Periwal *

Publish date

2014 Feb;


Description :

Empty ...