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9,10-Didehydroeffususol A

$1,376

  • Brand : BIOFRON

  • Catalogue Number : BN-O0930

  • Specification : 98%(HPLC)

  • CAS number : 1869082-57-4

  • Formula : C18H18O3

  • Molecular Weight : 282.33

  • Volume : 5mg

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Catalogue Number

BN-O0930

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

282.33

Appearance

Powder

Botanical Source

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2=C(C=CC(=C2)N(C)C)C3(C4=C1C=C(C=C4)N(C)C)C5=C(C=CC(=C5)C(=O)NCC6=CC=C(C=C6)COC7=NC(=NC8=C7NC=N8)N)C(=O)N3S(=O)(=O)N)C

Synonyms

N-[[4-[(2-amino-7H-purin-6-yl)oxymethyl]phenyl]methyl]-2,7-bis(dimethylamino)-9,9-dimethyl-1'-oxo-2'-sulfamoylspiro[anthracene-10,3'-isoindole]-5'-carboxamide

IUPAC Name

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C41H42N10O5S/c1-40(2)32-18-26(49(3)4)12-15-29(32)41(30-16-13-27(50(5)6)19-33(30)40)31-17-25(11-14-28(31)38(53)51(41)57(43,54)55)36(52)44-20-23-7-9-24(10-8-23)21-56-37-34-35(46-22-45-34)47-39(42)48-37/h7-19,22H,20-21H2,1-6H3,(H,44,52)(H2,43,54,55)(H3,42,45,46,47,48)

InChl Key

VPKVQWNFZROFRJ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:1869082-57-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27314045

Abstract

Background. The use of miRNAs as biomarkers for Type 1 Diabetes (T1D) risk is attractive as T1D is usually diagnosed in front of acute symptoms. As miR-375 is highly expressed in the endocrine pancreas, we postulated that its circulating level might reflect beta cell alterations and might be altered in the blood of T1D patients recently diagnosed. Methods. Sera were obtained from 22 T1D children at onset of the disease, before subcutaneous insulin treatment, and from 10 nondiabetic pediatric controls. MiR-375 seric level was quantified by stem-loop RT-PCR-based assay. MiRNAs regulations in isolated human islets in response to high glucose concentrations were determined by TaqMan Low-Density Array. Results. The abundance of miR-375, among the 410 miRNAs detected in human islets, mirrored its well-established role in rodent islet biology. Upregulated miRNAs targeted genes involved in islet homeostasis and regulation of beta cell mass. Downregulated miRNAs, including miR-375, were involved in pancreas secretion and protein turnover. Seric level of miR-375 was lower in T1D children versus age-matched controls, without any correlations with HbA1c, glycaemia, and number of autoantibodies. Conclusion. Altered circulating level of miR-375 at onset of T1D might be a general biomarker of metabolic alterations and inflammation associated with the disease.

Title

miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes

Author

Lucien Marchand, 1 , 2 Audrey Jalabert, 1 Emmanuelle Meugnier, 1 Kathleen Van den Hende, 3 Nicole Fabien, 4 Marc Nicolino, 1 , 3 Anne-Marie Madec, 1 Charles Thivolet, 1 , 2 and Sophie Rome 1 , *

Publish date

2016;


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