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Abietic acid

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-A3001

  • Specification : 98%

  • CAS number : 514-10-3

  • Formula : C20H30O2

  • Molecular Weight : 302.45

  • Volume : 25mg

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Catalogue Number

BF-A3001

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

302.45

Appearance

Powder

Botanical Source

herbs of Pinus massoniana

Structure Type

Terpenoids

Category

SMILES

CC(C)C1=CC2=CCC3C(C2CC1)(CCCC3(C)C(=O)O)C

Synonyms

IUPAC Name

Density

1.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C20H30O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h7,12-13,16-17H,5-6,8-11H2,1-4H3,(H,21,22)/t16-,17+,19+,20+/m0/s1

InChl Key

RSWGJHLUYNHPMX-ONCXSQPRSA-N

WGK Germany

RID/ADR

HS Code Reference

2916200000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:514-10-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31520265

Abstract

Dental caries is a type of oral microbiome dysbiosis and biofilm infection that affects oral and systemic conditions. For healthy life expectancy, natural bacteriostatic products are ideal for daily and lifetime use as anti-oral infection agents. This study aimed to evaluate the inhibitory effects of abietic acid, a diterpene derived from pine rosin, on the in vitro growth of cariogenic bacterial species, Streptococcus mutans. The effective minimum inhibitory concentration of abietic acid was determined through observation of S. mutans growth, acidification, and biofilm formation. The inhibitory effects of abietic acid on the bacterial membrane were investigated through the use of in situ viability analysis and scanning electron microscopic analysis. Cytotoxicity of abietic acid was also examined in the context of several human cell lines using tetrazolium reduction assay. Abietic acid was found to inhibit key bacterial growth hallmarks such as colony forming ability, adenosine triphosphate activity (both planktonic and biofilm), acid production, and biofilm formation. Abietic acid was identified as bacteriostatic, and this compound caused minimal damage to the bacterial membrane. This action was different from that of povidone-iodine or cetylpyridinium chloride. Additionally, abietic acid was significantly less cytotoxic compared to povidone-iodine, and it exerted lower toxicity towards epithelial cells and fibroblasts compared to that against monocytic cells. These data suggest that abietic acid may prove useful as an antibacterial and antibiofilm agent for controlling S. mutans infection.

KEYWORDS

Abietic acid; Antimicrobial; Oral biofilm; Streptococcus mutans; Terpene.

Title

Antimicrobial and antibiofilm effects of abietic acid on cariogenic Streptococcus mutans

Author

Yuki Ito 1, Takashi Ito 2, Keisuke Yamashiro 1, Fumi Mineshiba 1, Kimito Hirai 1, Kazuhiro Omori 1, Tadashi Yamamoto 1, Shogo Takashiba 3

Publish date

2020 Jan;

PMID

31288049

Abstract

Ethnopharmacological relevance: Rosin, an exudate of conifer trees such as Pinus masscnlana (Pinaceae), has been used to treat psoriasis for nearly two thousand years in China despite its so far undefined pharmacology. Unfortunately, the rosin intoxication is noted from time to time, but the water-boiled rosin (WBR) has been documented to be safer. This study was performed to evaluate the in vivo anti-psoriasis efficacy of WBR.

Materials and methods: The main phytochemicals in WBR were quantified by high performance liquid chromatography (HPLC). WBR was evaluated in the imiquimod-induced psoriasis-like inflammation mouse model for its anti-psoriasis effect at 130, 260, and 390 mg/kg, which were set according to the dose used for patients. Through a combination of q-PCR, flow cytometry, and histopathological and immunohistochemical (IHC) analysis, the in vivo efficacy was assessed in terms of the psoriasis area severity index (PASI), epidermal keratinocyte proliferation, Th1 and Th17 cell numbers in spleen, and mRNA expressions of inflammatory cytokines.

Result: Oral administration of WBR ameliorates the psoriasis-like dermatitis in the imiquimod-generated mouse model. In particular, WBR given at 260 or 390 mg/kg significantly restores the normal keratinization of dorsal lesion if compared with the untreated psoriatic mice. Such an effect was addressed to correlate to the Th1/Th17 cell reduction in spleen and the suppressed expression of IL-17A, IL-17F, IL-22, IL-23, TNF-α, K17, and proliferating cell nuclear antigen (PCNA) after the WBR administration.

Conclusion: WBR is effective in the imiquimod-induced psoriasis-like inflammation mouse model with the efficacy arising from its proliferation inhibition of Th1/Th17 cells and epidermal keratinocytes via the down-regulation of the relevant inflammatory cytokines such as IL-23, IL-17A, and IL-17F. Collectively, WBR harvested and processed in the traditional manner is an efficacious psoriasis-treating agent.

KEYWORDS

Anti-inflammation; Anti-psoriasis; IL-23/IL-17 axis; Rosin.

Title

Anti-psoriasis effect of water-processed rosin in mice

Author

Xiao Qiang Li 1, Yong Chen 2, Hong Mei Zhou 3, Hui Li Shi 4, Xiao Ning Yan 5, Li Ping Lin 6, Ren Xiang Tan 7

Publish date

2019 Oct 5;

PMID

30443982

Title

Allergic contact dermatitis caused by Finn Chambers AQUA in two patients

Author

Araceli Sanchez-Gilo 1, Enrique Gomez-de la Fuente 2, Francisco J Vicente-Martin 1

Publish date

2019 Apr 1


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