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Abrine

$60

  • Brand : BIOFRON

  • Catalogue Number : BD-P0311

  • Specification : 98.0%(HPLC)

  • CAS number : 526-31-8

  • Formula : C12H14N2O2

  • Molecular Weight : 218.25

  • PUBCHEM ID : 160511

  • Volume : 25mg

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Catalogue Number

BD-P0311

Analysis Method

Specification

98.0%(HPLC)

Storage

-20℃

Molecular Weight

218.25

Appearance

Cryst.

Botanical Source

This product is isolated and purified from the seeds of Abrus precatorius

Structure Type

Category

SMILES

CNC(CC1=CNC2=CC=CC=C21)C(=O)O

Synonyms

a-Methylamino-b-(3-indole)propionic Acid/N-ME-TRYPTOPHAN/L-N-Methyltryptophan/N-Methyl-L-tryptophan/L-Tryptophan, N-methyl-/H-METRP-OH/L-Abrine/Abrine/L-2-methyltryptophan/ABRINE,L/N-methyl-tryptophan/N-α-Methyl-L-trytophan/N(α)-methyl-L-tryptophan/N(α)-methyl-L-tryptophan zwitterion/N(alpha)-methyl-L-tryptophan/Nα-Methyl-L-tryptophan/N-ME-TRP-OH HCL/N-ME-TRP-OH

IUPAC Name

Applications

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

219.4±25.9 °C

Boiling Point

439.1±35.0 °C at 760 mmHg

Melting Point

>300 °C (dec.)(lit.)

InChl

InChl Key

CZCIKBSVHDNIDH-NSHDSACASA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:526-31-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29931062

Abstract

Ricin and abrin are toxic ribosome-inactivating proteins found in plants. Exposure to these toxins can be detected using the biomarkers ricinine and abrine, which are present in the same plant sources as the toxins. The concentration of the biomarkers in urine and blood will be dependent upon the purification of abrin or ricin, the route of exposure, and the length of time between exposure and sample collection. Here, we present the first diagnostic assay for the simultaneous quantification of both ricinine and abrine in blood matrices. Furthermore, this is the first-ever method for the detection of abrine in blood products. Samples were processed by isotope-dilution, solid-phase extraction, protein precipitation and quantification by HPLC-MS-MS. This analytical method detects abrine from 5.00 to 500 ng/mL and ricinine from 0.300 to 300 ng/mL with coefficients of determination of 0.996 ± 0.003 and 0.998 ± 0.002 (n = 22), respectively. Quality control material accuracy was determined to have <10% relative error, and precision was within 19% relative standard deviation. The assay's time-to-first result is three hours including sample preparation. Furthermore, the method was applied for the quantification of ricinine in the blood of a patient who had intentionally ingested castor beans to demonstrate the test was fit-for-purpose. This assay was designed to support the diagnosis of ricin and abrin exposures in public health investigations.

Title

Quantification of Ricinine and Abrine in Human Plasma by HPLC-MS-MS: Biomarkers of Exposure to Ricin and Abrin.

Author

Isenberg SL1, Carter MD1, Miller MA2, Noras AI3, Mojica MA4, Carlsen ST2, Bulathsinghala CP5, Thomas JD1, Johnson RC1.

Publish date

2018 Nov 1

PMID

19007169

Abstract

Abrine is an alkaloid chemical marker and surrogate analyte of abrin, a group of highly toxic glycoproteins. These toxins can be easily isolated from the seed of the rosary pea plant and distributed in a variety of matrices, including food. A procedure for the cleanup of abrine from various beverages, including milk, cola, juice drink, tea, and water, by C18 Strata-X solid-phase extraction (SPE) cartridges is described with comparison to a previously developed liquid-liquid extraction protocol utilizing acetonitrile and water. Analysis was by liquid chromatography/tandem mass spectrometry. Abrine quantitation was based on fragmentation of m/z 219.2 to product ion m/z 188.2. The method detection limit was 0.025 microg/mL, and the quantitation limit was 0.05 microg/mL. Fortifications of the five beverages at 0.5 and 0.05 microg/mL were recovered ranging from 88 to 111% [relative standard deviation (RSD) < 16%] by SPE and from 48 to 101% (RSD < 19%) by liquid-liquid extraction.

Title

Quantitation of abrine, an indole alkaloid marker of the toxic glycoproteins abrin, by liquid chromatography/tandem mass spectrometry when spiked into various beverages.

Author

Owens J1, Koester C.

Publish date

2008 Dec 10