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Acanthoside B

$672

  • Brand : BIOFRON

  • Catalogue Number : BD-P0764

  • Specification : 98.0%(HPLC&TLC)

  • CAS number : 7374-79-0

  • Formula : C28H36O13

  • Molecular Weight : 580.6

  • PUBCHEM ID : 443024

  • Volume : 10mg

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Catalogue Number

BD-P0764

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC&TLC)

Storage

2-8°C

Molecular Weight

580.6

Appearance

Powder

Botanical Source

Structure Type

Lignans

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC(=CC(=C1O)OC)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)OC5C(C(C(C(O5)CO)O)O)O)OC

Synonyms

(+)-syringaresinol beta-D-glucoside/acanthoside B/ELEUTHEROSIDE B+E/ELEUTHEROSIDE E1

IUPAC Name

(2S,3R,4S,5S,6R)-2-[4-[(3S,3aR,6S,6aR)-3-(4-hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2,6-dimethoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Applications

Density

1.4±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

424.6±32.9 °C

Boiling Point

778.5±60.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

WEKCEGQSIIQPAQ-IRBNZIFYSA-N

WGK Germany

RID/ADR

HS Code Reference

1302190000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:7374-79-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31077737

Abstract

Recently, our research team reported the anti-amnesic potential of desalted-hydroethanolic extracts of Salicornia europaea L. (SE-EE). In this study, we performed bioactivity-guided isolation and identification of Acanthoside B (Aca.B), from SE-EE, as the potential bioactive candidate and examined anti-amnesic activity with its potential mechanism of action using an in vivo model. S7-L3-3 purified from SE-EE showed enhanced in vitro acetylcholinesterase (AChE) inhibitory activity. The isolated S7-L3-3 was identified and characterized as Aca.B using varied spectral analyses, i.e., Nuclear magnetic resonance (NMR), Ultraviolet-visible (UV-Vis), and Electrospray ionization-mass spectrometry (ESI-MS). In the in vitro studies, Aca.B exhibited negligible toxicity and showed a dose-dependent nitric oxide inhibitory potential in Lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. In the in vivo studies, the oral administration of Aca.B to mice showed enhanced bioavailability and dose-dependent repression of the behavioral/cognitive impairment by regulating the cholinergic function, restoring the antioxidant status, attenuating the inflammatory cytokines/mediators and actively enriching neurotropic proteins in the hippocampal regions of the scopolamine-administered mice.

Copyright © 2019. Published by Elsevier Ltd.

KEYWORDS

Amnesia; Anti-AChE; Anti-inflammation; Antioxidant; Salicornia europaea L; Scopolamine; TrkB/CREB/BDNF

Title

Cognitive-enhancing and ameliorative effects of acanthoside B in a scopolamine-induced amnesic mouse model through regulation of oxidative/inflammatory/cholinergic systems and activation of the TrkB/CREB/BDNF pathway.

Author

Karthivashan G1, Kweon MH2, Park SY3, Kim JS4, Kim DH5, Ganesan P6, Choi DK7.

Publish date

2019 Jul;

PMID

24438013

Abstract

A simple and accurate liquid chromatographic method was developed for the simultaneous determination of six constituents in the fruit of Acanthopanax sessiliflorus. The conditions of sample extraction were optimised by using orthogonal design. The method provided good accuracy with recoveries in the range of 95.6-101.6% and good precision with RSD values less than 3.0%, which has been successfully applied to the quantitative determination of the six compounds in the fruit of A. sessiliflorus from two maturation periods.

Title

Simultaneous determination of six constituents in the fruit of Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem. by HPLC-UV.

Author

Zhao L1, An Q, Qin F, Xiong Z.

Publish date

2014

PMID

8003231

Abstract

Seven constituents were isolated from the dry herb Huanghuaren. On the basis of spectroscopic analysis and physico-chemical constants four of them were identified as heraclenol, beta-sitosterol, acanthoside B and daucoglycoside.

Title

[Studies on the chemical constituents of the herb huanghuaren (Sida acuta Burm. f.)].

Author

Cao JH1, Qi YP.

Publish date

1993 Nov;