(+)-syringaresinol beta-D-glucoside/acanthoside B/ELEUTHEROSIDE B+E/ELEUTHEROSIDE E1
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Recently, our research team reported the anti-amnesic potential of desalted-hydroethanolic extracts of Salicornia europaea L. (SE-EE). In this study, we performed bioactivity-guided isolation and identification of Acanthoside B (Aca.B), from SE-EE, as the potential bioactive candidate and examined anti-amnesic activity with its potential mechanism of action using an in vivo model. S7-L3-3 purified from SE-EE showed enhanced in vitro acetylcholinesterase (AChE) inhibitory activity. The isolated S7-L3-3 was identified and characterized as Aca.B using varied spectral analyses, i.e., Nuclear magnetic resonance (NMR), Ultraviolet-visible (UV-Vis), and Electrospray ionization-mass spectrometry (ESI-MS). In the in vitro studies, Aca.B exhibited negligible toxicity and showed a dose-dependent nitric oxide inhibitory potential in Lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. In the in vivo studies, the oral administration of Aca.B to mice showed enhanced bioavailability and dose-dependent repression of the behavioral/cognitive impairment by regulating the cholinergic function, restoring the antioxidant status, attenuating the inflammatory cytokines/mediators and actively enriching neurotropic proteins in the hippocampal regions of the scopolamine-administered mice.
Copyright © 2019. Published by Elsevier Ltd.
Amnesia; Anti-AChE; Anti-inflammation; Antioxidant; Salicornia europaea L; Scopolamine; TrkB/CREB/BDNF
Cognitive-enhancing and ameliorative effects of acanthoside B in a scopolamine-induced amnesic mouse model through regulation of oxidative/inflammatory/cholinergic systems and activation of the TrkB/CREB/BDNF pathway.
Karthivashan G1, Kweon MH2, Park SY3, Kim JS4, Kim DH5, Ganesan P6, Choi DK7.
A simple and accurate liquid chromatographic method was developed for the simultaneous determination of six constituents in the fruit of Acanthopanax sessiliflorus. The conditions of sample extraction were optimised by using orthogonal design. The method provided good accuracy with recoveries in the range of 95.6-101.6% and good precision with RSD values less than 3.0%, which has been successfully applied to the quantitative determination of the six compounds in the fruit of A. sessiliflorus from two maturation periods.
Simultaneous determination of six constituents in the fruit of Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem. by HPLC-UV.
Zhao L1, An Q, Qin F, Xiong Z.
Seven constituents were isolated from the dry herb Huanghuaren. On the basis of spectroscopic analysis and physico-chemical constants four of them were identified as heraclenol, beta-sitosterol, acanthoside B and daucoglycoside.
[Studies on the chemical constituents of the herb huanghuaren (Sida acuta Burm. f.)].
Cao JH1, Qi YP.