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Acetoxyisovalerylshikonin, β-

$250

  • Brand : BIOFRON

  • Catalogue Number : BF-A4006

  • Specification : 98%(HPLC)

  • CAS number : 69091-17-4

  • Formula : C23H26O8

  • Molecular Weight : 430.45

  • PUBCHEM ID : 155245

  • Volume : 20mg

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Catalogue Number

BF-A4006

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

430.45

Appearance

Red powder

Botanical Source

Arnebia euchroma

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)OC(=O)CC(C)(C)OC(=O)C)C

Synonyms

Butanoic acid, 3-(acetyloxy)-3-methyl-, 1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-pentenyl ester, (S)-/Alkannin-3-methyl-3-acetoxy-buttersaeureester/Butanoic acid, 3-(acetyloxy)-3-methyl-, (1S)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-penten-1-yl ester/(1S)-1-(5,8-Dihydroxy-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-4-methyl-3-penten-1-yl 3-acetoxy-3-methylbutanoate/β-acetoxyisovalerylalkannin/Acetoxyisovalerylshikonin, β-

IUPAC Name

[(1S)-1-(5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] 3-acetyloxy-3-methylbutanoate

Applications

Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma[1][2].

Density

1.3±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

196.5±23.6 °C

Boiling Point

583.6±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C23H26O8/c1-12(2)6-9-18(30-19(28)11-23(4,5)31-13(3)24)14-10-17(27)20-15(25)7-8-16(26)21(20)22(14)29/h6-8,10,18,25-26H,9,11H2,1-5H3/t18-/m0/s1

InChl Key

BQSAGDWOHVQNFB-SFHVURJKSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:69091-17-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31550255

Abstract

Linkage of medical databases, including insurer claims and electronic health records (EHRs), is increasingly common. However, few studies have investigated the behavior and output of linkage software. To determine how linkage quality is affected by different algorithms, blocking variables, methods for string matching and weight determination, and decision rules, we compared the performance of 4 nonproprietary linkage software packages linking patient identifiers from noninteroperable inpatient and outpatient EHRs. We linked datasets using first and last name, gender, and date of birth (DOB). We evaluated DOB and year of birth (YOB) as blocking variables and used exact and inexact matching methods. We compared the weights assigned to record pairs and evaluated how matching weights corresponded to a gold standard, medical record number. Deduplicated datasets contained 69,523 inpatient and 176,154 outpatient records, respectively. Linkage runs blocking on DOB produced weights ranging in number from 8 for exact matching to 64,273 for inexact matching. Linkage runs blocking on YOB produced 8 to 916,806 weights. Exact matching matched record pairs with identical test characteristics (sensitivity 90.48%, specificity 99.78%) for the highest ranked group, but algorithms differentially prioritized certain variables. Inexact matching behaved more variably, leading to dramatic differences in sensitivity (range 0.04-93.36%) and positive predictive value (PPV) (range 86.67-97.35%), even for the most highly ranked record pairs. Blocking on DOB led to higher PPV of highly ranked record pairs. An ensemble approach based on averaging scaled matching weights led to modestly improved accuracy. In summary, we found few differences in the rankings of record pairs with the highest matching weights across 4 linkage packages. Performance was more consistent for exact string matching than for inexact string matching. Most methods and software packages performed similarly when comparing matching accuracy with the gold standard. In some settings, an ensemble matching approach may outperform individual linkage algorithms.

Title

Comparing record linkage software programs and algorithms using real-world data

Author

Alan F. Karr, Conceptualization, Formal analysis, Methodology, Project administration, Validation, Writing - original draft, Writing - review & editing,1,* Matthew T. Taylor, Data curation, Formal analysis, Writing - original draft, Writing - review & editing,2,3 Suzanne L. West, Conceptualization, Funding acquisition, Methodology, Project administration, Writing - original draft, Writing - review & editing,1 Soko Setoguchi, Conceptualization, Writing - review & editing,2 Tzuyung D. Kou, Conceptualization, Funding acquisition, Writing - review & editing,4 Tobias Gerhard, Conceptualization, Data curation, Project administration, Writing - review & editing,2 and Daniel B. Horton, Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Validation, Writing - original draft, Writing - review & editing2

Publish date

2019

PMID

26543818

Abstract

Point-of-care measurement of the stress hormone cortisol will greatly facilitate the timely diagnosis and management of stress-related disorders. We describe an automated salivary cortisol immunosensor, incorporating centrifugal fluid valves and a disposable disc-chip that allows for truncated reporting of cortisol levels (<15 min). The performance characteristics of the immunosensor are optimized through select blocking agents to prevent the non-specific adsorption of proteins; immunoglobulin G (IgG) polymer for the pad and milk protein for the reservoirs and the flow channels. Incorporated centrifugal fluid valves allow for rapid and repeat washings to remove impurities from the saliva samples. An optical reader and laptop computer automate the immunoassay processes and provide easily accessible digital readouts of salivary cortisol measurements. Linear regression analysis of the calibration curve for the cortisol immunosensor showed 0.92 of coefficient of multiple determination, R2, and 38.7% of coefficient of variation, CV, for a range of salivary cortisol concentrations between 0.4 and 11.3 ng/mL. The receiver operating characteristic (ROC) curve analysis of human saliva samples indicate potential utility for discriminating stress disorders and underscore potential application of the biosensor in stress disorders. The performance of our salivary cortisol immunosensor approaches laboratory based tests and allows noninvasive, quantitative, and automated analysis of human salivary cortisol levels with reporting times compatible with point-of-care applications.

KEYWORDS

Immunosensor, Centrifugal fluid valve, Automation, Cortisol, Saliva

Title

Automated-immunosensor with centrifugal fluid valves for salivary cortisol measurement

Author

Masaki Yamaguchi,a,* Hiroki Katagata,a Yuki Tezuka,a Daisuke Niwa,b and Vivek Shettyc

Publish date

2014 Aug

PMID

30949486

Abstract

For decades, animal shelters in the U.S. have sought to reduce the number of cats that are impounded and euthanized. Since the 1990s, low-cost sterilization campaigns aimed at owned cats have achieved varying levels of success in meeting these objectives. Over a similar time period, the use of trap-neuter-vaccinate-return (TNVR), as a humane alternative to the lethal management of stray and feral cats, has proliferated. Because of the limited scope of many TNVR programs, the impacts of such efforts on shelter metrics have often proven difficult to measure. In the past decade, two new variants of TNVR, return-to-field (RTF) and high-impact targeting, have exhibited the capacity to contribute to significant reductions in shelter intake and euthanasia. The present study examines changes in feline intake and euthanasia, as well as impacts on associated metrics, at municipal shelters located in six diverse U.S. communities after integrated programs of RTF and targeted TNVR (collectively termed “community cat programs,” CCPs) were implemented. A total of 72,970 cats were enrolled in six 3-year CCPs, 71,311 of whom (98%) were sterilized, vaccinated, and returned to their location of capture or adopted. A median reduction of 32% in feline intake, as well as a median decline of 83% in feline euthanasia occurred across the six CCPs; median feline live-release rate increased by 53% as a result of these simultaneous declines in cat admissions and euthanasia. The integration of RTF and targeted TNVR protocols appears to result in greater feline intake and euthanasia reductions than programs lacking such an integrated approach.

KEYWORDS

return-to-field (RTF), trap-neuter-vaccinate-return (TNVR), targeted TNVR, unowned free-roaming cats, community cat program (CCP), feline intake, feline euthanasia, animal sheltering

Title

Integrated Return-To-Field and Targeted Trap-Neuter-Vaccinate-Return Programs Result in Reductions of Feline Intake and Euthanasia at Six Municipal Animal Shelters

Author

Daniel D. Spehar1 and Peter J. Wolf2,*

Publish date

2019