Polygonum cuspidatum sieb.et zucc.; Vitis vinifera L.
1,3-Benzenediol, 5-[(E)-2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate/3-Acetoxy-5-[(E)-2-(4-acetoxyphenyl)vinyl]phenyl acetate/5-[(1E)-2-[4-(acetyloxy)phenyl]ethenyl]-1,3-Benzenediol-1,3-diacetate/Acetyl trans-resveratrol/(E)-5-(4-Acetoxystyryl)-1,3-phenylene diacetate/Triacetyl resveratrol/3,4',5-Triacetoxy-trans-stilbene/Acetyl-trans-resveratrol/Acetic acid 4-[2-(3,5-diacetoxyphenyl)vinyl]phenyl ester/resveratrol triacetate/Acetyl-resveratrol
504.8±50.0 °C at 760 mmHg
117.0 to 121.0 °C
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:42206-94-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Golden retrievers are over-represented in cases of taurine-deficient dilated cardiomyopathy and recently a surge in cases has prompted further investigation.
To describe the clinical, dietary, and echocardiographic features in golden retrievers diagnosed with taurine deficiency and dilated cardiomyopathy, and to determine specific dietary associations. A second aim was to determine the whole blood taurine concentrations in a representative sample of healthy golden retrievers.
Twenty-four client-owned golden retrievers with documented taurine deficiency and dilated cardiomyopathy and 52 healthy client-owned golden retrievers.
In this multicenter prospective observational study, baseline and follow-up echocardiographic data, complete diet and medical histories, and whole blood, plasma, or serum taurine concentrations were obtained. Baseline and follow-up echocardiographic data were compared. Associations were evaluated between specific diets and taurine deficiency or congestive heart failure. The prevalence of low whole blood taurine concentrations in the healthy golden retrievers was calculated.
Twenty-three of 24 dogs diagnosed with taurine deficiency and dilated cardiomyopathy were fed diets that were either grain-free, legume-rich, or a combination of these factors. None of these diets were feeding trial tested using Association of American Feed Control Officials (AAFCO) procedures. Twenty-three of 24 dogs had significant improvement in their echocardiographic parameters and normalization of taurine concentrations following diet change and taurine supplementation. Nine of 11 dogs diagnosed with congestive heart failure (CHF) had resolution of their congestion at follow-up with five no longer requiring diuretic therapy and four tolerating diuretic dose reduction by >50%.
Certain diets and diet characteristics were associated with the development of taurine deficiency. Taurine deficiency and dilated cardiomyopathy in golden retrievers is likely multifactorial, including a combination of dietary, metabolic, and genetic factors.
Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets
Joanna L. Kaplan, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization, Writing - original draft, Writing - review & editing,1 Joshua A. Stern, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing,1,* Andrea J. Fascetti, Methodology, Resources, Visualization, Writing - review & editing,#2 Jennifer A. Larsen, Methodology, Resources, Visualization, Writing - review & editing,#2 Hannah Skolnik, Conceptualization, Data curation, Investigation, Methodology,1 Gordon D. Peddle, Resources, Writing - review & editing,3 Richard D. Kienle, Resources, Writing - review & editing,4 Andrew Waxman, Resources, Writing - review & editing,5 Michael Cocchiaro, Resources, Writing - review & editing,6 Catherine T. Gunther-Harrington, Resources, Writing - review & editing,1 Tyler Klose, Resources,7 Kendra LaFauci, Resources, Writing - review & editing,8 Bonnie Lefbom, Resources,9 Maggie Machen Lamy, Resources,10 Rebecca Malakoff, Resources, Writing - review & editing,11 Satoko Nishimura, Resources, Writing - review & editing,1 Maureen Oldach, Resources, Writing - review & editing,1 Steven Rosenthal, Resources,12 Christopher Stauthammer, Resources, Writing - review & editing,13 Lynne O’Sullivan, Resources, Writing - review & editing,14 Lance C. Visser, Resources, Writing - review & editing,1 Regan William, Resources, Writing - review & editing,15 and Eric Ontiveros, Data curation, Investigation, Methodology, Resources, Visualization, Writing - review & editing1
2018 Dec 13
In further study of our series of six-membered ring-containing nucleic acids, different 1′,3′-di-O-methyl altropyranoside nucleoside analogs (DMANA) were synthesized comprising all four base moieties, adenine, cytosine, uracil and guanine. Following assembly into oligonucleotides (ONs), their affinity for natural oligonucleotides was evaluated by thermal denaturation of the respective duplexes. Data were compared with results obtained previously for both anhydrohexitol (HNAs) and 3′-O-methylated altrohexitol modified ONs (MANAs). We hereby demonstrate that ONs modified with DMANA monomers, unlike some of our previously described analogues with constrained 6-membered hexitol rings, did not improve thermodynamic stability of dsRNA complexes, most probably in view of an energetic penalty when forced in the required 1C4 pairing conformation. Overall, a single incorporation was more or less tolerated or even positive for the adenine congener, but incorporation of a second modification afforded a slight destabilization (except for A), while a fully modified sequence displayed a thermal stability of ?0.3 °C per modification. The selectivity of pairing remained very high, and the new modification upon incorporation into a DNA strand, strongly destabilized the corresponding DNA duplexes. Unfortunately, this new modification does not bring any advantage to be further evaluated for antisense or siRNA applications.
modified oligonucleotides, hexitol nucleic acids, pairing behaviour, hybridisation, constrained oligonucleotides
Hybridisation Potential of 1',3'-Di-O-methylaltropyranoside Nucleic Acids
Akkaladevi Venkatesham,† Dhuldeo Kachare,† Guy Schepers, Jef Rozenski, Mathy Froeyen, and Arthur Van Aerschot*
2015 Mar 3.
In the title 1:2 co-crystal, C10H9N2 +·(C6H7.75O6·C6H7.25O6)?, l-ascorbic acid (LAA) and 4,4′-bipyridine (BPy) co-crystallize in the chiral space group P21 with two molecules of LAA, and one molecule of bpy in the asymmetric unit. The structure was modeled in two parts due to possible proton transfer from LAA to the corresponding side of the bpy molecule having an occupancy of approximately 0.25 and part 2 with an occupancy of approximately 0.75. In this structure, LAA forms hydrogen bonds with neighboring LAA molecules, forming extended sheets of LAA molecules which are bridged by bpy molecules. A comparison to a related and previously published co-crystal of LAA and 3-bromo-4-pyridone is presented.
crystal structure, co-crystal, charge transfer, l-ascorbic acid, 4,4′-bipyridine
Partial charge transfer in the salt co-crystal of l-ascorbic acid and 4,4′-bipyridine
Eric Sylvester,a Mitchell McGovern,a An Young Lee,a Phanxico Nguyen,a Jungeun Park,a and Jason B. Benedictb,*
2019 May 3.