Prod. by Valeriana spp. and by Centranthus ruber
DMSO : ≥ 125 mg/mL (260.15 mM)
*"≥" means soluble, but saturation unknown.
538.7±50.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
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Introduction: Valepotriates (epoxy iridoid esters) represent an important group of constituents that contribute to pharmacological effects for the genus Valeriana. Storage and extraction of valepotriates is a demanding task, as these compounds are thermolabile and unstable: even when decomposition products are not formed, isovaleric acid liberation from the iridoid nucleus originate compounds with less complex substituents.
Objective: To study the influence of time and storage conditions on the diene valepotriates (valtrate, isovaltrate, acevaltrate, 1-β-acevaltrate, 1-β-aceacevaltrate) content of the Valeriana glechomifolia (native to southern Brazil), extract was obtained by supercritical fluid extraction using CO₂ as the fluid (SF-CO₂).
Methodology: Above-ground and below-ground material of V. glechomifolia was extracted by SF-CO₂ (40 °C, 90 bar). The extract was stored under nitrogen atmosphere or solubilised in methanol. Valepotriates stability was accessed during storage at -20 °C over 8 months through reverse-phase HPLC (mobile phase acetonitrile:water 50:50 (v/v); 254 nm).
Results: A gradual increase in valtrate levels and decrease in acevaltrate, 1-β-acevaltrate and 1-β-aceacevaltrate, concentration were observed from the first month of storage for the dry extract. However, for the methanol solubilised extract these changes occurred only after the third month and were accompanied by reduction in isovaltrate levels and formation of decomposition products.
Conclusion: SF-CO₂ showed high selectivity for valepotriates extraction. This is the first report on valepotriates molecular conversion, which was less accelerated when the extract was stored in methanol, but under this condition degradation products are also present, probably baldrinals, that are not observed in the dry extract.
Effect of storage time and conditions on the diene valepotriates content of the extract of Valeriana glechomifolia obtained by supercritical carbon dioxide
Liz Girardi Muller 1, Luisa de Andrade Salles, Satchie Sakamoto, Ana Cristina Stein, Simone Tasca Cargnin, Eduardo Cassel, Rubem Figueiro Vargas, Stela Maris Kuze Rates, Gilsane Lino von Poser
In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases
Gustavo M Bettero 1, Luisa Salles, Renata M Rosario Figueira, Gilsane von Poser, Stela M K Rates, Francois Noël, Luis Eduardo M Quintas
2011 Oct 2
Objective: To provide scientific basis for the utilization and development of Valeriana jatamansi by setting up the quality control specification of V. jatamansi.
Method: The pharmacognostical methods were applied. The extract of V. jatamansi was examined. Moisture and ash were determined. And the bioactive constituents were analyzed by TLC and HPLC.
Result: The morphological and histological characters of V. jatamansi were observed. Content of total ash, acid-insoluble ash, and moisture of 15 samples from different habitats and times were determined. The qualitative and quantitative analysis of valtrate and acevaltrate by TLC and HPLC were preformed respectively.
Conclusion: The established method can be used for the quality control of V. jatamans.
[Study on quality specification of Rhizoma et Radix Valeriana Jatamansi]
Hong-ye Di 1, Jin-li Shi, Xing-li Yan, Ren Zhao, Yong Liu, Pei-gen Xiao