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Aescin B

$560

  • Brand : BIOFRON

  • Catalogue Number : BD-P0202

  • Specification : 98.0%(HPLC)

  • CAS number : 26339-90-2

  • Formula : C55H88O24

  • Molecular Weight : 1133.27

  • PUBCHEM ID : 6476031

  • Volume : 25mg

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Catalogue Number

BD-P0202

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

1133.27

Appearance

Powder

Botanical Source

Aesculi semen

Structure Type

Triterpenoids

Category

SMILES

CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C

Synonyms

(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid

IUPAC Name

(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid

Applications

Density

1.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

311.8±27.8 °C

Boiling Point

1140.6±65.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10-/t26-,27+,28+,29+,30+,31+,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42-,43-,44-,47-,48-,49+,51-,52+,53+,54+,55-/m0/s1

InChl Key

AXNVHPCVMSNXNP-OXPBSUTMSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:26339-90-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

Title

World Congress Integrative Medicine & Health 2017: part two Berlin, Germany. 3-5 May 2017

Author

Carolyn Ee,corresponding author1 Sharmala Thuraisingam,2 Marie Pirotta,2 Simon French,3 Charlie Xue,4 Helena Teede,5 Agnete E. Kristoffersen,corresponding author6 Fuschia Sirois,7 Trine Stub,8 Jennifer Engler,corresponding author9 Stefanie Joos,10 Corina Guthlin,9 Jennifer Felenda,11 Christiane Beckmann,11 Florian Stintzing,corresponding author12 Roni Evans,corresponding author13 Gert Bronfort,13 Daniel Keefe,13 Anna Taberko,14 Linda Hanson,13 Alex Haley,13 Haiwei Ma,13 Joseph Jolton,14 Lana Yarosh,13 Francis Keefe,13,15 Jung Nam,13 Roni Evans,corresponding author16 Liwanag Ojala,17 Mary J. Kreitzer,16 Linda Hanson,16 Careen Fink,corresponding author18 Karin Kraft,19 Andrew Flower,corresponding author20 George Lewith,20 Kim Harman,20 Beth Stuart,20 Felicity L. Bishop,21 Jane Frawley,corresponding author22 Lilla Fuleki,corresponding author23 Eva Kiss,23 Tamas Vancsik,23 Tibor Krenacs,23 Martha Funabashi,corresponding author24 Katherine A. Pohlman,24,25 Silvano Mior,26 Haymo Thiel,27 Michael D. Hill,28 David J. Cassidy,29 Michael Westaway,28 Jerome Yager,24 Eric Hurwitz,30 Gregory N. Kawchuk,24 Maeve O’Beirne,28 Sunita Vohra,24 Isabelle Gaboury,corresponding author31 Chantal Morin,31 Katharina Gaertner,corresponding author32 Loredana Torchetti,32 Martin Frei-Erb,32 Michael Kundi,33 Michael Frass,34 Eugenia Gallo,corresponding author35,36,37 Valentina Maggini,35,36,37 Mattia Comite,36,37 Francesco Sofi,35 Sonia Baccetti,38 Alfredo Vannacci,35 Mariella Di Stefano,38 Maria V. Monechi,38 Luigi Gori,36,37 Elio Rossi,38 Fabio Firenzuoli,36,37,38 Rocco D. Mediati,39 Giovanna Ballerini,39 Paula Gardiner,40,41 Anna S. Lestoquoy,corresponding author40 Lily Negash,40 Sarah Stillman,40 Prachi Shah,40 Jane Liebschutz,40,41 Pamela Adelstein,42 Christine Farrell-Riley,42 Ivy Brackup,43 Brian Penti,40 Robert Saper,40,41 Isabel Giralt Sampedro,corresponding author44,45 Gilda Carvajal,44 Andreas Gleiss,corresponding author46 Marie M. Gross,corresponding author47 Dorothea Brendlin,47 Jonas Rottger,47 Wiebke Stritter,47 Georg Seifert,47 Noelle Grzanna,corresponding author48 Rainer Stange,49 Peter W. Guendling,48 Wen Gu,50 Yan Lu,51 Jie Wang,52 Chengcheng Zhang,53 Hua Bai,54 Yuxi He,52 Xiaoxu Zhang,52 Zhengju Zhang,52 Dali Wang,52 Fengxian Meng,corresponding author52 Alexander Hagel,55 Heinz Albrecht,corresponding author55 Claudia Vollbracht,corresponding author56 Wolfgang Dauth,57 Wolfgang Hagel,58 Francesco Vitali,55 Ingo Ganzleben,55 Hans Schultis,59 Peter Konturek,60 Jurgen Stein,61 Markus Neurath,55 Martin Raithel,55 Alexander Hagel,corresponding author62 Claudia Vollbracht,63 Martin Raithel,62 Peter Konturek,64 Bianka Krick,63 Heidemarie Haller,corresponding author65 Petra Klose,65 Gustav Dobos,65 Sherko Kummel,66 Holger Cramer,65 Heidemarie Haller,corresponding author67 Felix J. Saha,67 Anna Kowoll,67 Barbara Ebner,67 Bettina Berger,68 Gustav Dobos,67 Kyung-Eun Choi,67 Lisha He,69 Han Wang,69 X. He,69 C. Gu,69 Y. Zhang,69 Linhua Zhao,corresponding author69 Xiaolin Tong,69 Lisha He,corresponding author70 Han Wang,70 Xinhui He,70 Chengjuan Gu,70 Ying Zhang,70 Linhua Zhao,70 Xiaolin Tong,70 Lisha He,corresponding author71 Han Wang,71 Xinhui He,71 Chengjuan Gu,71 Ying Zhang,71 Linhua Zhao,71 Xiaolin Tong,71 Robin S. T. Ho,corresponding author72 Vincent C. H. Chung,72,73 Xinyin Wu,73 Charlene H. L. Wong,73 Justin C. Y. Wu,73 Samuel Y. S. Wong,72 Alexander Y. L. Lau,73 Regina W. S. Sit,72,73 Wendy Wong,73 Michelle Holmes,corresponding author74 Felicity Bishop,74 Lynn Calman,75 Michelle Holmes,corresponding author76 Felicity Bishop,76 George Lewith,77 Dave Newell,78 Jonathan Field,79 Win L. Htut,80 Dongwoon Han,corresponding author80 Da I. Choi,80 Soo J. Choi,80 Ha Y. Kim,80 Jung H. Hwang,80 Ching W. Huang,corresponding author81,82 Bo H. Jang,81,82 Fang P. Chen,83 Seong G. Ko,81,82 Wenjing Huang,84 De Jin,84 Fengmei Lian,corresponding author84 Soobin Jang,corresponding author85 Kyeong H. Kim,85 Eun K. Lee,85 Seung H. Sun,86 Ho Y. Go,87 Youme Ko,85 Sunju Park,88 Bo H. Jang,85 Yong C. Shin,85 Seong G. Ko,85 Hubert Janik,corresponding author89 Natalie Greiffenhagen,89 Jurgen Bolte,90 Karin Kraft,89 Mariusz Jaworski,corresponding author91 Miroslawa Adamus,91 Aleksandra Dobrzynska,91 Michael Jeitler,corresponding author92 Jessica Jaspers,93 Christel von Scheidt,92 Barbara Koch,92 Andreas Michalsen,92,93 Nico Steckhan,93 Christian Kessler,92,93 De Jin,94 Wen-jing Huang,94 Bing Pang,94 Feng-Mei Lian,corresponding author94 Miek Jong,corresponding author95 Erik Baars,95 Anja Glockmann,96 Harald Hamre,96 Mosaburo Kainuma,97,98 Aya Murakami,97,98 Toshio Kubota,97,98 Daisuke Kobayashi,97,98 Yasuhiro Sumoto,97,98 Norihiro Furusyo,99 Shin-Ichi Ando,100 Takao Shimazoe,97,98 Olaf Kelber,corresponding author101 S. Verjee,102 Eva Gorgus,102 Dieter Schrenk,102 Kathi Kemper,corresponding author103 Ellie Hill,103 Kathi Kemper,104 Nisha Rao,105 Gregg Gascon,104 John Mahan,104 Gunver Kienle,corresponding author106 Jorg Dietrich,107 Claudia Schmoor,108 Roman Huber,106 Weon H. Kim,corresponding author109 Dongwoon Han,110 Mansoor Ahmed,110 Luzhu He,110 Jung Hye Hwang,110 Eva Kiss,corresponding author111 Tamas Vancsik,111 Nora Meggyeshazi,111 Csaba Kovago,112 Tibor Krenacs,111 Anne K. Klaus,corresponding author113,114 Roland Zerm,113,114 Danilo Pranga,113 Thomas Ostermann,115,116 Marcus Reif,117 Hans Broder von Laue,113 Benno Brinkhaus,118 Matthias Kroz,113 Anne K. Klaus,corresponding author119,120 Roland Zerm,119,119 Danilo Pranga,119 Daniela Rodrigues Recchia,121 Thomas Ostermann,121,122 Marcus Reif,123 Hans B. von Laue,119 Benno Brinkhaus,124 Matthias Kroz,119,120,121,124 Christien T. Klein-Laansma,corresponding author125 Mats Jong,126 Cornelia von Hagens,127 Jean P. Jansen,125 Herman van Wietmarschen,125 Miek C. Jong,125 Youme Ko,corresponding author128 Seung-Ho Sun,129 Ho-Yeon Go,130 Chan-Yong Jeon,131 Yun-Kyung Song,132 Seong-Gyu Ko,128 Anna K. Koch,corresponding author133,134 Sybille Rabsilber,135,136 Romy Lauche,133,137 Sherko Kummel,136 Gustav Dobos,133 Jost Langhorst,133,134 Holger Cramer,133,137 Anna K. Koch,corresponding author138,139 Milena Trifunovic-Koenig,138,139 Petra Klose,138 Holger Cramer,138,140 Gustav Dobos,138 Jost Langhorst,138,139 Evi Koster,corresponding author141 Erik Baars,141 Diana Delnoij,142 Lena Kroll,corresponding author143 Kathrin Weiss,143 Ai Kubo,corresponding author144 Sarah Hendlish,144 Andrea Altschuler,144 Nancy Connolly,144 Andy Avins,144,145 Romy Lauche,146 Daniela Rodrigues Recchia,147 Holger Cramer,corresponding author146 Jon Wardle,146 David Lee,148 David Sibbritt,146 Jon Adams,146 Thomas Ostermann,147 Romy Lauche,149 David Sibbritt,149 Crystal Park,150 Gita Mishra,151 Jon Adams,149 Holger Cramer,corresponding author149,152 Johann Lechner,corresponding author153 Inseon Lee,154 Younbyoung Chae,corresponding author155 Jisu Lee,156 Seung H. Cho,corresponding author157 Yujin Choi,157 Jee Y. Lee,corresponding author158 Han S. Ryu,158 Sung S. Yoon,158 Hye K. Oh,158 Lyun K. Hyun,158 Jin O. Kim,158 Seong W. Yoon,158 Ju-Yeon Lee,159 Sang-Hoon Shin,160 Min Jang,160 Indra Muller,159 So-Hyun Janson Park,corresponding author159 Anna S. Lestoquoy,corresponding author161 Lance Laird,162 Lily Negash,161 Suzanne Mitchell,162 Paula Gardiner,161 Xiaofei Li,163,164 Yunhui Wang,163 Jianhua Zhen,163,165 He Yu,corresponding author163 Tiegang Liu,163 Xiaohong Gu,163 Hui Liu,corresponding author166 Weiguo Ma,166 Chengcheng Zhang,166 Xuezheng Shang,166 Yu Bai,166 Fengxian Meng,166 Wei Liu,corresponding author167 Collin Rooney,168 Amos Smith,169 Shirlene Lopes,corresponding author170 Marcelo Demarzo,171 Maria do Patrocinio Nunes,170 Peter Lorenz,172 Carsten Grundemann,173 Miriam Heinrich,172 Manuel Garcia-Kaufer,173 Franziska Grunewald,173 Silke Messerschmidt,172 Anja Herrick,174 Kim Gruber,corresponding author174 Christiane Beckmann,174 Matthias Knodler,172 Roman Huber,173 Carmen Steinborn,173 Florian Stintzing,172,174 Taoying Lu,corresponding author175 Lixin Wang,176 Darong Wu,175 Christina M Luberto,corresponding author177,178 Daniel L. Hall,177,178 Emma Chad-Friedman,178 Suzanne Lechner,179 Elyse R. Park,177,178 Christina M. Luberto,corresponding author180 Elyse Park,180 Janice Goodman,180 Sonja Luer,corresponding author181 Matthias Heri,182 Klaus von Ammon,182 Martin Frei-Erb,182 Weiguo Ma,corresponding author183 Fengxian Meng,183 Valentina Maggini,corresponding author184,186 Eugenia Gallo,184,186 Ida Landini,184 Andrea Lapucci,184 Stefania Nobili,185 Enrico Mini,184 Fabio Firenzuoli,186 Clare McDermott,corresponding author187 George Lewith,corresponding author187 Selwyn Richards,188 Diane Cox,188 Sarah Frossell,190 Geraldine Leydon,187 Caroline Eyles,187 Hilly Raphael,190 Rachael Rogers,191 Michelle Selby,188 Charlotte Adler,188 Jo Allam,188 Fengxian Meng,corresponding author192 Wen Gu,193 Chengcheng Zhang,194 Hua Bai,195 Zhengju Zhang,192 Dali Wang,192 Xiangwei Bu,192 Honghong Zhang,192 Jianpeng Zhang,192 Hui Liu,192 Michael Mikolasek,corresponding author196 Jonas Berg,196 Claudia Witt,196 Jurgen Barth,196 Ivan Miskulin,corresponding author197 Zdenka Lalic,198 Maja Miskulin,197,199 Albina Dumic,200 Damir Sebo,197 Aleksandar Vcev,200 Nasr A. A. Mohammed,corresponding author201 Dongwoon Han,201 Mansoor Ahmed,202 Soo Jeung Choi,522 Hyea Bin Im,522 Jung Hye Hwang,522 Anwesha Mukherjee,corresponding author203 Amit Kandhare,203 Subhash Bodhankar,203 Anwesha Mukherjee,corresponding author204 Amit Kandhare,204 Prasad Thakurdesai,205 Subhash Bodhankar,204 Niki Munk,corresponding author206 Erica Evans,206 Amanda Froman,207 Matthew Kline,207 Matthew J. Bair,206 Frauke Musial,corresponding author208 Agnete E. Kristoffersen,208 Terje Alræk,1 Harald J. Hamre,209 Trine Stub,208 Lars Bjorkman,210 Vinjar M. Fønnebø,208 Bing Pang,211 Feng-mei Lian,211 Qing Ni,corresponding author211 Xiao-lin Tong,corresponding author211 Xin-long Li,212 Wen-ke Liu,211 Shuo Feng,213 Xi-yan Zhao,211 Yu-jiao Zheng,211 Xue-min Zhao,211 Yi-qun Lin,211 Bing Pang,214 Feng-mei Lian,corresponding author214 Xiao-lin Tong,corresponding author214 Tian-yu Zhao,215 Xi-Yan Zhao,214 Hui Che Phd,216 Chen Zhang,214 Bing Pang,217 Feng Liu,corresponding author218 Xiao-lin Tong,corresponding author217 Lin-hua Zhao,217 Xue-min Zhao,217 Ru Ye,217 Cheng-juan Gu,217 Bing Pang,219 Qing Ni,corresponding author220 Xiao-lin Tong,corresponding author220 Feng-mei Lian,220 Xi-yan Zhao,220 De Jin,220 Xue-min Zhao,220 Yu-jiao Zheng,220 Yi-qun Lin,220 Wenbo Peng,corresponding author221 Romy Lauche,221 David Sibbritt,221 Jon Adams,221 Wenbo Peng,corresponding author222 Jon Wardle,222 Holger Cramer,223 Gita Mishra,224 Romy Lauche,222 Katherine A. Pohlman,225,226 Silvano Mior,227 Martha Funabashi,corresponding author225 Diana De Carvalho,228 Mohamed El-Bayoumi,229 Bob Haig,230 Kimbalin Kelly,230 Darrell J. Wade,231 Maeve O’Beirne,232 Sunita Vohra,225 Emanuela Portalupi,corresponding author233,234 Giampietro Gobo,235 Luigi Bellavita,233,236 Chiara Guglielmetti,237 Christa Raak,corresponding author238 Myriam Teuber,239,240 Friedrich Molsberger,corresponding author239,240,241 Ulrich von Rath,corresponding author242 Ulrike Reichelt,corresponding author243 Uta Schwanebeck,244 Sabine Zeil,245 Christian Vogelberg,245 Dolores Rodriguez Veintimilla,corresponding author246 Claudia Vollbracht,247 Guerrero Tapia Mery,246 Marisol Maldonado Villavicencio,246 Sandra Herrera Moran,246 Christian Sachse,corresponding author248 Peter W Gundlin,249 Rainer Stange,248 Monirsadat Sahebkarkhorasani,250 Hoda Azizi,251 Dania Schumann,corresponding author252 Romy Lauche,253 Tobias Sundberg,253,254 Matthew J. Leach,253 Holger Cramer,252,253 Susana Seca,corresponding author255,256 Henry Greten,257 Sugir Selliah,corresponding author258 Anu Shakya,corresponding author259 Dongwoon Han,259 Ha Yun Kim,260 Da I. Choi,523 Hyea B. Im,523 Soo J. Choi,523 Anna Sherbakova,corresponding author261,262 Gudrun Ulrich-Merzenich,261 Olaf Kelber,263 Heba Abdel-Aziz,264 Erica Sibinga,265 Lindsey Webb,266 Jonathan Ellen,267 Kari Skrautvol,268 Dagfinn Nåden,268 Rhayun Song,corresponding author269 Weronika Grabowska,270 Kamila Osypiuk,270 Gloria V. Diaz,271 Paolo Bonato,271 Moonkyoung Park,272 Jeffrey Hausdorff,273 Michael Fox,274 Lewis R. Sudarsky,275 Daniel Tarsy,274 James Novakowski,270 Eric A. Macklin,276 Peter M. Wayne,270 Rhayun Song,corresponding author277 Inok Hwang,278 Sukhee Ahn,277 Myung-Ah Lee,279 Peter M. Wayne,280 Min K. Sohn,278 Oleg Sorokin,corresponding author281 Nico Steckhan,282 Dagmar Heydeck,283 Astrid Borchert,283 Christoph-Daniel Hohmann,282 Harmut Kuhn,283 Andreas Michalsen,282 Christian Kessler,282 Nico Steckhan,corresponding author284 Christoph-Daniel Hohmann,284 Holger Cramer,284 Andreas Michalsen,284 Gustav Dobos,284 Christel von Scheidt,284 Clemens Kirschbaum,284 Tobias Stalder,284 Barbara Stockigt,corresponding author285 Michael Teut,285 Ralf Suhr,285 Daniela Sulmann,285 Benno Brinkhaus,285 Chris Streeter,corresponding author286,287 Patrica Gerbarg,288 Marisa Silveri,286,287 Richard Brown,289 John Jensen,287 Wiebke Stritter,corresponding author290 Britta Rutert,290,291 Angelika Eggert,290 Alfred Langler,292 Georg Seifert,290 Christine Holmberg,291 Jin Sun,corresponding author293 Xin Deng,294 Wen-Yuan Li,293 Bin Wen,294 Nicola Robinson,295 Jian-Ping Liu,293 Hyun K. Sung,corresponding author296 Narae Yang,296 Ho Y. Go,297 Seon M. Shin,298 Hee Jung,299 Young J. Kim,297 Woo S. Jung,300 Tae Y. Park,296 Kiyoshi Suzuki,corresponding author301 Toshinori Ito,302 Seiya Uchida,303 Seika Kamohara,304 Naoya Ono,304 Mitsuyuki Takamura,corresponding author305 Ayumu Yokochi,306 Kazuo Maruyama,305,306 Patricio Tapia,corresponding author307 Katarzyna Thabaut,corresponding author308 Benno Brinkhaus,308 Barbara Stockigt,308 Anja Thronicke,corresponding author309 Matthias Kroz,309,310,311 Megan Steele,309 Harald Matthes,310,310 Cornelia Herbstreit,310 Friedemann Schad,309,310 Jiaxing Tian,312 Fengmei Lian,312 Libo Yang,313 Xiaolin Tong,312 Tian Tian,corresponding author314 Hewei Zhang,314 Xia Tian,corresponding author315 CongCong Wang,315 Qian Yun Chai,315 Lijuan Zhang,316 Ruyu Xia,315 Na Huang,315 Yutong Fei,315 Jianpin Liu,315 Natalie Trent,corresponding author317,318 Mindy Miraglia,319 Jeffrey Dusek,320 Edi Pasalis,319 Sat B. Khalsa,317,318 Milena Trifunovic-Konig,corresponding author321,322 Petra Klose,322 Holger Cramer,322,323 Romy Lauche,322,323 Anna Koch,321,322 Gustav Dobos,322 Jost Langhorst,321,322 Lisa Uebelacker,corresponding author324,325 Geoffrey Tremont,325,326 Lee Gillette,327 Gary Epstein-Lubow,324,325,328 David Strong,328 Ana Abrantes,324,325 Audrey Tyrka,324,325 Tanya Tran,326 Brandon Gaudiano,324,325 Ivan Miller,324,325 Gerhild Ullmann,corresponding author329 Gerhild Ullmann,corresponding author330 Yuhua Li,331 Sujata Vaidya,corresponding author332 Vinod Marathe,332,333 Ana C. Vale,corresponding author334 Jacquelyne Motta,334 Fabiola Donadão,334 Angela C. Valente,corresponding author335 Luana C. Carvalho Valente,335 Ricardo Ghelman,335 Dusan Vesovic,corresponding author336 Dragan Jevdic,337 Aleksandar Jevdic,338 Katarina Jevdic,339 Mihael Djacic,339 Dragica Letic,340 Drago Bozic,340 Marija Markovic,340 Slobodan Dunjic,341 Dusan Vesovic,corresponding author342 Dragan Jevdic,343 Aleksandar Jevdic,344 Katarina Jevdic,345 Mihael Djacic,345 Dragica Letic,346 Drago Bozic,346 Marija Markovic,346 Gordana Ruscuklic,347 Dezire Baksa,347 Slobodan Dunjic,348 Dusan Vesovic,corresponding author349 Dragan Jevdic,350 Aleksandar Jevdic,351 Katarina Jevdic,352 Mihael Djacic,352 Dragica Letic,353 Drago Bozic,353 Marija Markovic,353 Gordana Ruscuklic,354 Dezire Baksa,354 Slobodan Dunjic,355 Dusan Vesovic,corresponding author356 Dragan Jevdic,357 Aleksandar Jevdic,358 Katarina Jevdic,359 Mihael Djacic,359 Dragica Letic,360 Drago Bozic,360 Marija Markovic,360 Gordana Ruscuklic,361 Dezire Baksa,361 Slobodan Dunjic,362 Dusan Vesovic,corresponding author363 Dragan Jevdic,364 Aleksandar Jevdic,365 Katarina Jevdic,366 Mihael Djacic,366 Dragica Letic,367 Drago Bozic,367 Marija Markovic,367 Kenan Vrca,368 Slobodan Dunjic,369 Ann Vincent,corresponding author370 Dietlind Wahner-Roedler,370 Mary Whipple,370 Maria M. Vogelius,corresponding author371 Claudia Vollbracht,372 Iris Friesecke,corresponding author372,373 Peter W. Gundling,corresponding author372 Dietlind Wahner-Roedler,corresponding author374 Saswati Mahapatra,374 Rebecca Hynes,374 Kimberly Van Rooy,374 Sherry Looker,374 Aditya Ghosh,374 Brent Bauer,374 Susanne Cutshall,374 Harald Walach,corresponding author375 Ana Borges Flores,376 Harald Walach,corresponding author377 Michael Ofner,378 Andreas Kastner,379 Gerhard Schwarzl,380 Hermann Schwameder,381 Nathalie Alexander,381 Gerda Strutzenberger,381 Jie Wang,382 Yan Lu,383 Wen Gu,384 Chengcheng Zhang,385 Xianwei Bu,382 Honghong Zhang,382 Jianping Zhang,382 Yuxi He,382 Xiaoxu Zhang,382 Fengxian Meng,corresponding author382 Shang Wang,corresponding author386 He Yu,386 Jinfeng Shi,386 Yu Hao,386 Tiegang Liu,386 Jun Wu,386 Zeji Qiu,386 Xiaohong Gu,386 Yuh-Hai Wang,387 Chi-Jung Lou,387 Sam Watts,corresponding author388 Peter Wayne,corresponding author389 Kamila Osypiuk,389 Gloria Vergara-Diaz,390 Paolo Bonato,390 Brian Gow,389 Jeffrey Hausdorff,391 Jose Miranda,392 Lewis Sudarsky,393 Daniel Tarsy,394 Michael Fox,395 Eric Macklin,396 Kathrin Wode,corresponding author397 Jenny Bergqvist,398 Britt-Marie Bernhardsson,399 Johanna Hok Nordberg,397,399 Gunver Kienle,400 Lena Sharp,397 Roger Henriksson,397,401 Yeonju Woo,402 Min K. Hyun,corresponding author403 Hao Wu,404 Tian-Fang Wang,corresponding author404 Yan Zhao,404 Yu Wei,404 Lei Tian,404 Lei He,404 Xue Wang,404 Ruohan Wu,corresponding author405 Shuo Feng,405 Mei Han,405 Patrina H. Y. Caldwell,406 Shigang Liu,407 Jing Zhang,408 Jianping Liu,405 Ruyu Xia,corresponding author409 Qianyun Chai,410 Yutong Fei,411 Zhongning Guo,412 Congcong Wang,413 Zhijun Liu,414 Xun Li,409 Ying Zhang,409 Jianping Liu,409 I. J. Yang,corresponding author415 V. Ruberio Lincha,415 S. H. Ahn,416 D. U. Lee,417 H. M. Shin,415,418 Lu Yang,corresponding author419 David Sibbritt,419 Wenbo Peng,419 Jon Adams,419 N. Yang,corresponding author420 H. Sung,421 S. M. Shin,422 H. Y. Go,421 H. Jung,423 Y. Kim,421 T. Y. Park,424 Angela Yap,425 Yu H. Kwan,425 Chuen S. Tan,426 Syed Ibrahim,427 Seng B. Ang,428 Alfred Yayi,corresponding author429 Dongwoon Han,429 Hyea Bin Im,429 Jung Hye Hwang,429 Soo Jeung Choi,429 Jeong E. Yoo,corresponding author430 Ho R. Yoo,431 Sae B. Jang,430 Hye L. Lee,432 Ala’a Youssef,corresponding author433 Shahira Ezzat,434 Amira Abdel Motaal,434 Hesham El-Askary,434 Xiaotong Yu,corresponding author435,436 Yashan Cui,435 Ying Zhang,436 Fengmei Lian,435 Younghee Yun,437 Youme Ko,438 Jin-Hyang Ahn,437 Bo-Hyung Jang,438 Kyu-Seok Kim,439 Seong-Gyu Ko,438 Inhwa Choi,corresponding author437 Roland Zerm,corresponding author440,441 Augustina Glinz,440 Danilo Pranga,440 Bettina Berger,442 Fadime ten Brink,443 Marcus Reif,444 Arnd Bussing,441 Christoph Gutenbrunner,444 Matthias Kroz,440,441,442,445 Roland Zerm,corresponding author446,447 Bert Helbrecht,446 Danilo Pranga,446 Benno Brinkhaus,448 Andreas Michalsen,448 Matthias Kroz,446,447,448,449 Honghong Zhang,corresponding author450 Tiesheng Fang,451 Jie Wang,450 Chengcheng Zhang,452 Yuxi He,450 Xiaoxu Zhang,450 Zhengju Zhang,450 Dali Wang,450 Fengxion Meng,450 Jianping Zhang,corresponding author453,454 Chengcheng Zhang,453,454,455 Hua Bai,455 Zhiming Shen,456,457 Weiguo Ma,456,457 Hui Liu,456,457 Yu Bai,456,457 Xuezheng Shang,456,457 Fengxian Meng,456,457 Ruixin Zhang,corresponding author458 Fan Wu,459 Ming Li,459 Xinyun Xuan,458 Xueyong Shen,459 Ke Ren,460 Brian Berman,458 Jianhua Zhen,corresponding author461 Xiaofei Li,461 Xiaohong Gu,461 He Yu,461 Zian Zheng,461 Yuxiang Wan,461 Yunhui Wang,461 Xueyan Ma,461 Fei Dong,461 Tiegang Liu,461 Jianhua Zhen,corresponding author462 Xiaofei Li,462 Xiaohong Gu,462 He Yu,462 Zian Zheng,462 Yuxiang Wan,462 Yunhui Wang,462 Xueyan Ma,462 Fei Dong,462 Tiegang Liu,462 Suzie Zick,corresponding author463 Richard Harris,463 Go E. Bae,464 Jung N. Kwon,corresponding author464 Hye Y. Lee,464 Jong K. Nam,465 Sang D. Lee,465 Dong H. Lee,465 Ji Y. Han,465 Young J. Yun,464 Ji H. Lee,464 Hye L. Park,464 Seong H. Park,464 Chiara Bocci,corresponding author466 Giovanni B. Ivaldi,466 Ilaria Vietti,466 Ilaria Meaglia,466 Marta Guffi,466 Rubina Ruggiero,466 Marita Gualea,466 Emanuela Longa,466 Massimo Bonucci,corresponding author467 Sarah Croke,corresponding author468 Lourdes Diaz Rodriguez,corresponding author469 Juan C. Caracuel-Martinez,470 Manuel F. Fajardo-Rodriguez,470 Angélica Ariza-Garcia,470 Francisca Garcia-De la Fuente,470 Manuel Arroyo-Morales,469 Maria S. Estrems,corresponding author471 Vicente G. Gómez,472 Maria S. Estrems,corresponding author473 Mónica Valero Sabater,474 Rosaria Ferreri,corresponding author475 Simonetta Bernardini,475 Roberto Pulcri,475 Franco Cracolici,475 Massimo Rinaldi,475 Claudio Porciani,475 Fabio Firenzuoli,corresponding author476,477 Sonia Baccetti,477 Mariella Di Stefano,477 Maria V. Monechi,477 Eugenia Gallo,476 Valentina Maggini,476 Luigi Gori,476 Elio Rossi,477 Peter Fisher,corresponding author478 John Hughes,478 Ariadna Mendoza,479 Hugh MacPherson,480 Claudia Witt,481 Jacqueline Filshie,482 George Lewith,483 Antonia Di Francesco,corresponding author484 Alberto Bernardini,484 Monica Messe,484 Vincenzo Primitivo,484 Piera A. Iasella,484 Ricardo Ghelman,corresponding author485 Monica Taminato,485 Jaqueline Do Carmo Alcantara,485 Katia R. De Oliveira,485 Debora C. De Azevedo Rodrigues,485 Juliana R. Campana Mumme,485 Olga K. Matsumoto Sunakozawa,485 Vicente Odone Filho,485 Georg Seifert,486 Joshua Goldenberg,487,488 Andrew Day,487 Masa Sasagawa,487 Lesley Ward,488,489 Kieran Cooley,488,490 Thora Gunnarsdottir,corresponding author491 Ingibjorg Hjaltadottir,491 Mahdie Hajimonfarednejad,corresponding author492 Nicole Hannan,corresponding author493 Rut Hellsing,494 Kathrin Wode,494 Johanna Hok Nordberg,495 Johanna Hok Nordberg,corresponding author496 Susanne Andermo,496 Maria Arman,496 Iris von Horsten,497 Patricia Vásquez Torrielo,497 Carmen L. Andrade Vilaró,497 Francisco Cerda Cabrera,498 Roman Huber,corresponding author499 Henny Hui,500 Eric Ziea,500 Dora Tsui,500 Joyce Hsieh,500 Christine Lam,500 Edith Chan,500 Mark P. Jensen,501 Samuel L. Battalio,501 Joy Chan,501 Karlyn A. Edwards,501 Kevin J. Gertz,501 Melissa A. Day,502 Leslie H. Sherlin,503 Dawn M. Ehde,501 Kyeong H. Kim,corresponding author504 Soobin Jang,504 Bo-Hyoung Jang,504 Ho-Yeon Go,504 Sunju Park,504 Seong-Gyu Ko,504 Karin Kraft,corresponding author505 Hubert Janik,505 Anja Borner,506 Jihong Lee,507 Boram Lee,corresponding author507 Gyu T. Chang,507 Alejandra Menassa,corresponding author508 Yoshiharu Motoo,corresponding author509 Jurgen Muller,510 Sabine Rabini,511 Bettina Vinson,510 Olaf Kelber,corresponding author510 Martin Storr,512,513 Karin Kraft,514 Martin Niemeijer,corresponding author515 Erik Baars,515 Joop Hoekman,515 Wied Ruijssenaaars,515 Faith C. Njoku,corresponding author516 Petra Klose,517 Benno Brinkhaus,518 Andreas Michalsen,518 Gustav Dobos,517 Holger Cramer,517 Arne J. Norheim,corresponding author519 Terje Alræk,519 Filiz Okumus,corresponding author520 and Halime Oncu-Celik521

Publish date

2017;

PMID

27210519

Abstract

Small incision lenticule extraction (SMILE) becomes a procedure to correct myopia. The extracted lenticule can be used for other clinical scenarios. To prepare for allogeneic implantation, lenticule decellularization with preserved optical property, stromal architecture and chemistry would be necessary. We evaluated different methods to decellularize thin human corneal stromal lenticules created by femtosecond laser. Treatment with 0.1% sodium dodecylsulfate (SDS) followed by extensive washes was the most efficient protocol to remove cellular and nuclear materials. Empty cell space was found inside the stroma, which displayed aligned collagen fibril architecture similar to native stroma. The SDS-based method was superior to other treatments with hyperosmotic 1.5 M sodium chloride, 0.1% Triton X-100 and nucleases (from 2 to 10 U/ml DNase and RNase) in preserving extracellular matrix content (collagens, glycoproteins and glycosaminoglycans). The stromal transparency and light transmittance was indifferent to untreated lenticules. In vitro recellularization showed that the SDS-treated lenticules supported corneal stromal fibroblast growth. In vivo re-implantation into a rabbit stromal pocket further revealed the safety and biocompatibility of SDS-decellularized lenticules without short- and long-term rejection risk. Our results concluded that femtosecond laser-derived human stromal lenticules decellularized by 0.1% SDS could generate a transplantable bioscaffold with native-like stromal architecture and chemistry.

Title

Decellularization of human stromal refractive lenticules for corneal tissue engineering

Author

Gary Hin-Fai Yam,1,2 Nur Zahirah Binte M. Yusoff,1 Tze-Wei Goh,1 Melina Setiawan,1 Xiao-Wen Lee,1 Yu-Chi Liu,1,3 and Jodhbir S. Mehtaa,1,2,3,4

Publish date

2016

PMID

31844545

Abstract

The supplementation effects of sea tangle powders were determined for the meat quality in Korean native black goats. A total 90 castrated male black goats at 3-month age were divided into 3 dietary treatment groups: control (basal diet + mineral block), T1 (0.3% sea tangle feeding with the basal diet), T2 (0.9% sea tangle feeding with the basal diet). At 9-months feeding, 10 goats per treatment group were slaughtered, and the longissimus dorsi muscle samples were vacuum-packed, and subsequently analyzed for physicochemical evaluations. Analysis revealed decrease in the shear force and TBARS values of meat in the sea tangle dietary groups (p < 0.05). The T2 group exhibited increased levels of unsaturated fatty acids such as C16:1, C18:1, C18:2, and C20:4 (p < 0.05). The content of free amino acids with desirable taste such as aspartic acid, glutamic acid, glycine, histidine, and serine were higher in T2, whereas alanine content was higher in both sea tangle dietary groups, as compared to control (p < 0.05). These data indicate that feeding dietary sea tangle as an alternative mineral source results in an improvement in the physicochemical profiles of goat meat.

KEYWORDS

Black goat, Sea tangle, Physicochemical quality, Fatty acid, Free amino acid

Title

Sea tangle (Laminaria japonica) supplementation on meat quality of Korean native black goat

Author

Dong-Gyun Yim,1 Young-Sun Choi,2 and Ki-Chang Nam3,*

Publish date

10.5187/jast.2019.61.6.352