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Allantoin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-A3023

  • Specification : 98%

  • CAS number : 97-59-6

  • Formula : C4H6N4O3

  • Molecular Weight : 158.12

  • PUBCHEM ID : 204

  • Volume : 100mg

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Catalogue Number

BF-A3023

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

158.12

Appearance

White crystalline powder

Botanical Source

Dioscorea polystachya

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C1(C(=O)NC(=O)N1)NC(=O)N

Synonyms

Allantol/DL-Allantoin/uniderma/ALL/Allantoin/Septalan/N-(2,5-Dioxo-4-imidazolidinyl)urea/2,5-Dioxo-4-imidazolidinyl-urea/Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI)/4-ureido-2,5-Imidazolidinedione/toin/5-ureidohydantoin/ALANTOIN/(±)-Allantoin/Sebical/4H-imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]-/Urea, (2,5-dioxo-4-imidazolidinyl)-/Alantan/1-(2,5-Dioxoimidazolidin-4-yl)harnstoff/Allantoin (8CI)/1-(2,5-dioxoimidazolidin-4-yl)urea/2,5-dioxo-4-imidazolidinyl urea/1-(2,5-Dioxo-4-imidazolidinyl)urea/Urea, N-(2,5-dioxo-4-imidazolidinyl)-/Psoralon/5-Ureido-2,4-imidazolidindion/5-ureido-Hydantoin

IUPAC Name

(2,5-dioxoimidazolidin-4-yl)urea

Density

1.7±0.1 g/cm3

Solubility

Water

Flash Point

230-234°C

Boiling Point

478ºC

Melting Point

230 °C (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2933210000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:97-59-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29505874

Abstract

Allantoin is widely used in pharmaceutical and cosmetic products, and is composed of a hydantoin ring and a ureido group. Recent reports showed that allantoin suppresses thermal aggregation of hen egg white lysozyme (LYZ). However, structural insight into the properties of allantoin on protein aggregation and whether allantoin controls the aggregation of other proteins under different stress conditions remain unclear. Here we studied the structural properties of allantoin in terms of its effects on protein aggregation by comparing allantoin with urea and hydantoin. Furthermore, we analyzed the effects of allantoin and its derivatives on the aggregation of LYZ, carbonic anhydrase from bovine erythrocytes (BCA), albumin from chicken egg white (OVA), and immunoglobulin G (IgG) by various stresses in comparison with arginine. These four proteins are widely different in charged state and molecular size. Allantoin suppressed the aggregation and inactivation of LYZ comparing to arginine without affecting the melting temperature of proteins, and was responsible for the slightly improved formation of soluble oligomers and insoluble aggregates of IgG with thermal and acidic stresses. In contrast, hydantoin increased the solubility of aromatic amino acids more effectively than arginine and allantoin. The structural properties underlying the observed effects of allantoin as an aggregation suppressor include hydrophobic interactions between hydantoin moiety and aromatic ring on the surface of proteins, which is reflected on the difference between allantoin and arginine. These results show that the backbone of hydantoin ring may be a new category of additives for development of small aggregation suppressors.

Copyright © 2018 Elsevier B.V. All rights reserved.

KEYWORDS

Allantoin; Hydantoin ring; Protein aggregation

Title

Allantoin and hydantoin as new protein aggregation suppressors.

Author

Nishinami S1, Yoshizawa S1, Arakawa T2, Shiraki K3.

Publish date

2018 Jul 15

PMID

30582339

Abstract

PURPOSE:
Gastritis is found to be one of the most common gastrointestinal diseases worldwide. However, current therapeutic agents cause side effects, interaction, and recurrence. Allantoin has anti-inflammatory and wound healing properties. In this study, the therapeutic effect of allantoin has been assessed on the histopathological indices and gastric mucosal barrier of male rats.

METHODS:
Male rats were equally divided into control, ethanol-induced gastritis, and allantoin groups. The therapeutic groups consisted of gastritis plus 12.5 mg/kg allantoin, gastritis plus 25 mg/kg allantoin, and gastritis plus 50 mg/kg allantoin groups. After 5 days of allantoin administration, the rats were sacrificed and a part of their gastric tissue was maintained at -70 °C for prostaglandin E2 (PGE2) and non-protein sulfhydryl (NP-SH) measurements. Another part was stained with hematoxylin and eosin and Masson’s trichrome.

RESULTS:
We found that Allantoin increased parietal and mucosal cell counts and mucosal thickness after gastritis induction. In addition, the number of leukocytes and vessels decreased in both of the mucosal and the submucosal layers. Allatoin improved gastric ulcer in all treatment groups. Gastric levels of PGE2 and NP-SH increased after allantoin treatment.

CONCLUSION:
This study indicated that allantoin had a considerable effect on gastritis treatment, which seems to result from the reinforcement of gastric mucosal barrier.

KEYWORDS

allantoin; ethanol; gastritis; prostaglandin E2; stomach

Title

Allantoin improves histopathological evaluations in a rat model of gastritis.

Author

Eslami-Farsani M1, Moslehi A2, Hatami-Shahmir A3.

Publish date

2018 Dec 1

PMID

31677368

Abstract

A TLC-densitometric method for determination of allantoin in Symphytum officinale root was developed. Densitometric quantification of allantoin was carried out on TLC Si60 plates with butanol-50 % methanol/formic acid, 66.5:33.2:0.3 (V/V/V) as developing solvent, at a wavelength of 190 nm. The method was preliminarily validated in terms of specificity, linearity, precision, limit of detection, limit of quantification, recovery and robustness. The results of TLC quantification were compared with HPLC analysis carried out on a HILIC Luna NH2 100A column, with mobile phase consisting of acetonitrile/water 80:20 (V/V) and UV detection at 190 and 210 nm. Allantoin content was determined in two herbal products and it varied from 0.94 to 2.09 %, depending on the producer, and was in agreement with literature reports.

KEYWORDS

HPLC; Symphytum officinale; TLC; allantoin; densitometry

Title

HPLC; Symphytum officinale; TLC; allantoin; densitometry

Author

Kimel K1, Zienkiewicz M1, Sparzak-Stefanowska B1, Krauze-Baranowska M1.

Publish date

2020 Mar 1


Description :

Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.