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Allocholic acid

$400

  • Brand : BIOFRON

  • Catalogue Number : BN-O1848

  • Specification : 98%(HPLC)

  • CAS number : 2464-18-8

  • Formula : C24H40O5

  • Molecular Weight : 408.6

  • PUBCHEM ID : 160636

  • Volume : 20mg

In stock

Quantity
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Catalogue Number

BN-O1848

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

408.6

Appearance

Botanical Source

Structure Type

Category

SMILES

Synonyms

IUPAC Name

(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

Applications

Density

1.184g/cm3

Solubility

Flash Point

321ºC

Boiling Point

583.9ºC at 760 mmHg

Melting Point

250-251ºC

InChl

InChl Key

BHQCQFFYRZLCQQ-PGHAKIONSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:2464-18-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28538412

Abstract

Background: This study aimed to explore the related metabolic biomarkers and to observe the effects of Yangxin Decoction (YXD) on plasma metabolism of patients with unstable angina (UA).

Methods: In total, 10 patients with UA (intervention group) and 10 healthy participants (control group) were recruited for this study from January 2009 to December 2010. Plasma samples from both groups were analyzed using liquid chromatography mass spectrometry (LC-MS). Principle component analysis (PCA) and partial least squares (PLS) were used to explore the correlations between metabolic markers in patients with UA.

Results: The LC-MS results indicated that the serum levels of 5 potential metabolic markers, namely, ceramide, glycocholic acid, allocholic acid, lithocholic acid, and leukotriene (LT) B4, were significantly higher in the intervention group than those in the control group.

Conclusion: The results of this study demonstrated potential metabolic markers that can be used to distinguish and diagnose patients with UA.

Title

Biomarkers of unstable angina pectoris and yangxin decoction intervention: An exploratory metabonomics study of blood plasma

Author

Xiao-Hong Yu 1, Jing Sun, Yan Wang, Ya-Bin Zhou

Publish date

2017 May

PMID

26746785

Abstract

Bile salts are steroid biosurfactants that have a significant role in fat digestion, cholesterol micellar solubilization, and regulation of metabolism. They are important in pharmaceutical studies as modulators of the transport-permeability of drugs or as ligands for certain receptors. For the rational application of bile salts in medicine, it is necessary to have detailed knowledge of their aggregation capabilities (which determine their membranotoxicity and solubilization capacity). From the examination of bile salt derivatives, the in plane of lnk (RPHPLC) and micelle aggregation number n, as well as the anion of 7-oxodeoxycholic acid (7-OxD) and anion of cholic acid (C), are considered to be outliers, related to linear hydrophobic congeneric groups, which means that their micelles, in addition to being determined by hydrophobic interactions, are determined by hydrogen bonds, i.e., they form micelles with higher aggregation numbers than would be expected from the hydrophobicity of their steroid skeleton. For bile salts of the normal series in the formation of hydrogen bonds in secondary micelles, the crucial structural elements of the steroid skeleton are: α-equatorial-C3-OH group and α-axial-C12-OH group. Bile salts of the allo series, including allocholic (aC), allodeoxycholic (aDC) and allochenodeoxycholic acid (aCD), belong to the linear hydrophobic congeneric group. Their micelles are determined by hydrophobic interactions. It is assumed that for the analyzed allo derivatives, the A ring of the steroid skeleton is in the twisted boat conformation, which explains the spatial sheltering of their C3-OH group in micelles.

KEYWORDS

Aggregation number; Critical micelle concentration; Linear congeneric group; Steroid skeleton.

Title

Chemometric and conformational approach to the analysis of the aggregation capabilities in a set of bile salts of the allo and normal series

Author

Mihalj Poša 1, Ana Sebenji 2

Publish date

2016 Mar 20;

PMID

16132221

Abstract

Adult sea lampreys locate spawning streams in the Great Lakes by using a migratory pheromone that is released by stream-resident larval conspecifics. Behavioral, electrophysiological, and biochemical analyses of larval release water have suggested that this pheromone is composed of several components, one of which is petromyzonol sulfate (PS), a known lamprey-specific bile acid. Its precursor, allocholic acid (ACA), has also been implicated. In this study, we employed high-performance liquid chromatography and mass spectrometry to look for both bile acids in various stream waters, thereby testing whether they might have a role in natural pheromone function. Although PS was measured at picomolar concentrations in streams known to contain larval lampreys and attract migratory adults, ACA was not. Neither compound was measured in streams lacking larvae. This finding indicates that PS is a component of the natural pheromone, and it suggests that ACA has little relevance.

Title

Biologically relevant concentrations of petromyzonol sulfate, a component of the sea lamprey migratory pheromone, measured in stream water

Author

Jared M Fine 1, Peter W Sorensen

Publish date

2005 Sep