White crystalline powder
Zanthoxylum nitidum,Macleaya cordata,Chelidonium majus,Corydalis yanhusuo,Corydalis saxicola
allo-Cryptopine/Allocryptopine/β-Homochelidonine/Benzo[c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-/[1,3]Benzodioxolo[5,6-e]benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-/5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo[e][1,3]dioxolo[4,5-k]benzazecin-14(6H)-one/5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one/Thalictrimine/Fagarine I/a-allo-Cryptopine/Benzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-/3,4-Dimethoxy-6-methyl-5,7,8,15-tetrahydrobenzo[c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one/α-Fagarine
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
552.7±50.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:485-91-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Cardiovascular Diseases and Natural Products.
Chen Z1, Liu Z1, Peng Y1, Leng L1, Du L1, Xu T2, Wang D1,2,3.
Abstract：Throughout the last decade, extensive efforts have been devoted to developing a percutaneous catheter ablation and implantable cardioverter-defibrillator technique for patients suffering from ventricular arrhythmia. Antiarrhythmic drug efficacy for preventing arrhythmias remains disappointing because of adverse cardiovascular effects. Allocryptopine is an isoquinoline alkaloid widely present in medicinal herbs. Studies have indicated that allocryptopine exhibits potential anti-arrhythmic actions in various animal models. The potential therapeutic benefit of allocryptopine in arrhythmia diseases is addressed in this study, focusing on multiple ion channel targets and reduced repolarization dispersion. The limitations of allocryptopine research are clear given a lack of parameters regarding toxicology and pharmacokinetics and clinical efficacy in patients with ventricular arrhythmias. Much remains to be revealed about the properties of allocryptopine.
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Allocryptopine; anti-arrhythmic; electrophysiological mechanism; proarrhythmia; properties; ventricular arrhythmia.
Allocryptopine: A Review of Its Properties and Mechanism of Antiarrhythmic Effect.
Li J1, Li B2, Huang H1, Han T1, Li Y3.
We aimed to study the effect of allocryptopine (All) on the late sodium current (INa,Late) of atrial myocytes in spontaneously hypertensive rats (SHR).
The enzyme digestion method was used to separate single atrial myocytes from SHR and Wistar-Kyoto (WKY) rats. INa,Late was recorded using the patch-clamp technique, and the effect of All was evaluated on the current.
Compared with WKY rat cells, an increase in the INa,Late current in SHR myocytes was found. After treatment with 30 µM All, the current densities were markedly decreased; the ratio of INa,Late/INa,peak of SHR was reduced by 30 µM All. All reduced INa,Late by alleviating inactivation of the channel and increasing the window current of the sodium channel. Furthermore, INa,Late densities of three SCN5A mutations declined substantially with 30 µM All in a concentration-dependent manner.
The results clearly show that an increase in INa,Late in SHR atrial myocytes was inhibited by All derived from Chinese herbal medicine.
allocryptopine ; atrial myocytes ; late sodium current ; spontaneously hypertensive rats
Change in late sodium current of atrial myocytes in spontaneously hypertensive rats with allocryptopine treatment.
Dong Y1, Huang Y2, Wu HL1, Ke J3, Yin YL1, Zhu C1, Li B1, Li J1, Gao L1, Xue Q1, Zhang JC4, Li Y5.
2019 Mar/Apr 23
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Corydalis decumbens (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current.