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Allocryptopine

$600

  • Brand : BIOFRON

  • Catalogue Number : BF-A4021

  • Specification : 98%(HPLC)

  • CAS number : 485-91-6

  • Formula : C21H23NO5

  • Molecular Weight : 369.42

  • PUBCHEM ID : 98570

  • Volume : 20mg

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Catalogue Number

BF-A4021

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

369.42

Appearance

White crystalline powder

Botanical Source

Zanthoxylum nitidum,Macleaya cordata,Chelidonium majus,Corydalis yanhusuo,Corydalis saxicola

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C(=C(C=C4)OC)OC)OCO3

Synonyms

allo-Cryptopine/Allocryptopine/β-Homochelidonine/Benzo[c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-/[1,3]Benzodioxolo[5,6-e][2]benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-/5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo[e][1,3]dioxolo[4,5-k][3]benzazecin-14(6H)-one/5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one/Thalictrimine/Fagarine I/a-allo-Cryptopine/Benzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-/3,4-Dimethoxy-6-methyl-5,7,8,15-tetrahydrobenzo[c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one/α-Fagarine

IUPAC Name

7,8-dimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

288.1±30.1 °C

Boiling Point

552.7±50.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

HYBRYAPKQCZIAE-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2934990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:485-91-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31592748

Title

Cardiovascular Diseases and Natural Products.

Author

Chen Z1, Liu Z1, Peng Y1, Leng L1, Du L1, Xu T2, Wang D1,2,3.

Publish date

2019

PMID

31389311

Abstract

Abstract:Throughout the last decade, extensive efforts have been devoted to developing a percutaneous catheter ablation and implantable cardioverter-defibrillator technique for patients suffering from ventricular arrhythmia. Antiarrhythmic drug efficacy for preventing arrhythmias remains disappointing because of adverse cardiovascular effects. Allocryptopine is an isoquinoline alkaloid widely present in medicinal herbs. Studies have indicated that allocryptopine exhibits potential anti-arrhythmic actions in various animal models. The potential therapeutic benefit of allocryptopine in arrhythmia diseases is addressed in this study, focusing on multiple ion channel targets and reduced repolarization dispersion. The limitations of allocryptopine research are clear given a lack of parameters regarding toxicology and pharmacokinetics and clinical efficacy in patients with ventricular arrhythmias. Much remains to be revealed about the properties of allocryptopine.

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

KEYWORDS

Allocryptopine; anti-arrhythmic; electrophysiological mechanism; proarrhythmia; properties; ventricular arrhythmia.

Title

Allocryptopine: A Review of Its Properties and Mechanism of Antiarrhythmic Effect.

Author

Li J1, Li B2, Huang H1, Han T1, Li Y3.

Publish date

2019;

PMID

30882133

Abstract

AIM:
We aimed to study the effect of allocryptopine (All) on the late sodium current (INa,Late) of atrial myocytes in spontaneously hypertensive rats (SHR).

METHODS:
The enzyme digestion method was used to separate single atrial myocytes from SHR and Wistar-Kyoto (WKY) rats. INa,Late was recorded using the patch-clamp technique, and the effect of All was evaluated on the current.

RESULTS:
Compared with WKY rat cells, an increase in the INa,Late current in SHR myocytes was found. After treatment with 30 µM All, the current densities were markedly decreased; the ratio of INa,Late/INa,peak of SHR was reduced by 30 µM All. All reduced INa,Late by alleviating inactivation of the channel and increasing the window current of the sodium channel. Furthermore, INa,Late densities of three SCN5A mutations declined substantially with 30 µM All in a concentration-dependent manner.

CONCLUSIONS:
The results clearly show that an increase in INa,Late in SHR atrial myocytes was inhibited by All derived from Chinese herbal medicine.

KEYWORDS

allocryptopine ; atrial myocytes ; late sodium current ; spontaneously hypertensive rats

Title

Change in late sodium current of atrial myocytes in spontaneously hypertensive rats with allocryptopine treatment.

Author

Dong Y1, Huang Y2, Wu HL1, Ke J3, Yin YL1, Zhu C1, Li B1, Li J1, Gao L1, Xue Q1, Zhang JC4, Li Y5.

Publish date

2019 Mar/Apr 23


Description :

Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Corydalis decumbens (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current[1][2].