Catalogue Number
BF-A3026
Analysis Method
HPLC,NMR,MS
Specification
98%
Storage
2-8°C
Molecular Weight
270.28
Appearance
White crystalline powder
Botanical Source
Zingiber officinale,Juglans mandshurica,Litsea rubescens,Alpinia hainanensis
Structure Type
Flavonoids
Category
Standards;Natural Pytochemical;API
SMILES
COC1=CC(=CC2=C1C(=O)CC(O2)C3=CC=CC=C3)O
Synonyms
7-hydroxy-5-methoxy-2-phenyl-chroman-4-one/(2S)-7-Hydroxy-5-methoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one/(S)-7-Hydroxy-5-methoxyflavanone/Alpinetin: 7-hydroxy-5-methoxy-2-phenylchroman-4-one/(2S)-7-Hydroxy-5-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one/7-Hydroxy-5-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one/4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-5-methoxy-2-phenyl-, (2S)-/(S)-7-Hydroxy-5-methoxy-2-phenylchroman-4-one/7-Hydroxy-5-methoxy-2-phenyl-chroman-4-on/4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-5-methoxy-2-phenyl-/Alpinetin
IUPAC Name
(2S)-7-hydroxy-5-methoxy-2-phenyl-2,3-dihydrochromen-4-one
Density
1.3±0.1 g/cm3
Solubility
Methanol; DMSO
Flash Point
188.8±22.2 °C
Boiling Point
494.9±45.0 °C at 760 mmHg
Melting Point
223-224ºC
InChl
InChl Key
QQQCWVDPMPFUGF-ZDUSSCGKSA-N
WGK Germany
RID/ADR
HS Code Reference
2932990000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:36052-37-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
MSDS
26321118
Alpinetin, a novel plant flavonoid isolated from Alpinia katsumadai Hayata, has been demonstrated to have anti-inflammatory and antioxidant effects. However, the effects of alpinetin on lipopolysaccharide (LPS)-induced acute kidney injury have not been reported. In the present study, we investigated the protective effects and the underlying mechanism of alpinetin against LPS-induced acute kidney injury in mice. The results showed that alpinetin inhibited LPS-induced kidney histopathologic changes, blood urea nitrogen (BUN) and creatinine levels. Alpinetin also inhibited LPS-induced ROS, MDA, and inflammatory cytokines TNF-α, IL-6 and IL-1β production in kidney tissues. Meanwhile, Western blot analysis showed that alpinetin suppressed LPS-induced TLR4 expression and NF-κB activation in kidney tissues. In addition, alpinetin was found to up-regulate the expression of Nrf2 and HO-1 in a dose-dependent manner. In conclusion, alpinetin protected LPS-induced kidney injury through activating Nrf2 and inhibiting TLR4 expression.
Acute kidney injury; Alpinetin; LPS; NF-κB; Nrf2.
Alpinetin Inhibits Lipopolysaccharide-Induced Acute Kidney Injury in Mice
Yi Huang 1 , Li-shan Zhou 2 , Li Yan 3 , Juan Ren 1 , Dai-xing Zhou 4 , Shu-Sheng Li 4
2015 Oct
30132572
Natural bioactive components are increasingly being applied in cancer research. Alpinetin is a type of natural flavonoid primarily derived from Alpinia katsumadai Hayata, which exhibits anti‑bacterial and anti‑inflammatory properties. Therefore, it may possess anticancer potential and be employed therapeutically for different diseases. The aim of the present study was to investigate the anticancer effects of alpinetin on the SKOV3 ovarian cancer cell line. The effect of alpinetin treatment on SKOV3 cell proliferation, apoptosis, spheroid and colony formation were measured using Cell Counting kit‑8, cell apoptosis, 3D spheroid and colony formation assays, respectively. Analysis of the cell cycle was performed using flow cytometry. Western blot analysis was used to determine the protein expression levels of B‑cell lymphoma (Bcl)‑2, Bcl‑2‑associated X protein, cleaved caspase‑3, cleaved poly (ADP‑ribose) polymerase (PARP), cyclin D1, cyclin‑dependent kinase (CDK) 4, CDK6, signal transducer and activator of transcription (STAT) 3, phosphorylated (p)‑STAT3, c‑myc, survivin, tissue inhibitor of metalloproteinase (TIMP)‑1, TIMP‑2, matrix metalloproteinase (MMP)‑2 and MMP‑9. In addition, a wound healing assay was used to determine cancer cell migration. The results revealed alpinetin suppressed cell viability and induced apoptosis of SKOV3 cells in a dose‑ and time‑dependent manner, and cells were arrested in the G1 phase. Alpinetin treatment upregulated protein expression levels of Bax, cleaved caspase‑3 and PARP, and downregulated protein expression levels of Bcl‑2, cyclin D1, CDK4 and CDK6. Alpinetin also inhibited cell migration, through increased protein expression levels of TIMP‑1 and TIMP‑2, and decreased protein expression levels of MMP‑2 and MMP‑9. Alpinetin also significantly suppressed colony and spheroid formation by SKOV3 cells. In addition, the STAT3 pathway was suppressed as demonstrated by downregulation of p‑STAT3 and reduced expression of downstream factors, including c‑myc and survivin. Overall, these results indicated that alpinetin may have anticancer effects on human ovarian cancer by inhibiting the STAT3 signaling pathway.
Acute kidney injury; Alpinetin; LPS; NF-κB; Nrf2.
Alpinetin Inhibits Proliferation and Migration of Ovarian Cancer Cells via Suppression of STAT3 Signaling
Xuezhi Zhao 1 , Xiaohan Guo 1 , Junhua Shen 1 , Dingchao Hua 1
2018 Oct
30048861
Alpinetin has been reported to have anti-inflammatory effects. However, whether alpinetin has anti-inflammatory effects in LPS-induced endometritis has not been thoroughly elucidated to date. The aim of this study was to investigate the protective effects of alpinetin on LPS-induced endometritis in mice. A mouse model of endometritis was induced by LPS and alpinetin was given 1 h before LPS treatment. According to the results, alpinetin protected mice against LPS-induced endometritis by attenuating uterine histological changes and myeloperoxidase (MPO) activity. The LPS-induced inflammatory response was inhibited by alpinetin as confirmed by the inhibition of TNF-α, IL-1ß, and IL-6 production. Furthermore, LPS-induced TLR4 expression and NF-κB activation were significantly suppressed by alpinetin. In addition, the expression of PPAR-γ was dose-dependently increased by the treatment of alpinetin. Taken together, the results of this study showed that alpinetin had protective effects against LPS-induced endometritis in mice, and the beneficial effects were occurred through the activation of PPAR-γ and inhibition of the TLR4 signaling pathway.
Alpinetin; Endometritis; LPS; PPAR-γ.
Alpinetin Ameliorates Inflammatory Response in LPS-induced Endometritis in Mice
Yuanjiao Liang 1 , Tao Shen 2 , Qi Ming 2 , Guoqing Han 2 , Yan Zhang 2 , Jinlan Liang 2 , Duanrong Zhu 3
2018 Sep
Description :
Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity[1].
