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Ammonium glycyrrhizinate

$68

  • Brand : BIOFRON

  • Catalogue Number : AV-P11525

  • Specification : 98%

  • CAS number : 53956-04-0

  • Formula : C42H61O16.NH4

  • Molecular Weight : 839.97

  • PUBCHEM ID : 62074

  • Volume : 25mg

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Catalogue Number

AV-P11525

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

839.97

Appearance

White crystalline powder

Botanical Source

Glycyrrhiza uralensis Fisch.

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N

Synonyms

GLYCAMIL/Ammoniumglycynhizinato/glycyrrhizic acid monoammonium salt/ammonium glycyrrhizinate/Glycyrrhizin Monoammonium Salt Hydrate/Glycyrrhizic Acid Monoammonium Salt Hydrate/(3β)-30-Hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid diammoniate/GLYCYRRHIZICAMMONIUM/Magnasweet/ammoniate/Monoammonium Glycyrrhizinate Hydrate/Glycyrrhizate monoammonium/Glycyrrhizin ammonium/Olean-12-en-30-oic acid, 3-[(2-O-β-D-glucopyranuronosyl-α-D-glucopyranuronosyl)oxy]-11-oxo-, diammonium salt, (3β)-/Glycyrrhiz/AMMONIUMGLYCYRRHIZIN/Ammonium glycyrrhizate/GLYCYRRHIZIC ACID,NH4/ammoniumglycyrrhizate/Monoammoniumglycyrrhizinate/Glycyrrhizic acid monoammonium salt trihydrate/Olean-12-en-30-oic acid, 3-[(2-O-β-D-glucopyranuronosyl-α-D-glucopyranuronosyl)oxy]-11-oxo-, ammonium salt, (3β)-/glycyrram

IUPAC Name

(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid;azane

Density

1.43g/cm3

Solubility

Water; Methanol

Flash Point

288.1ºC

Boiling Point

971.4ºC at 760mmHg

Melting Point

209ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:53956-04-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

25298583

Abstract

OBJECTIVE:
The objective of this study was to evaluate the cardioprotective effect of herbal bioactive compound ammonium glycyrrhizinate against doxorubicin-induced cardiomyopathy, in experimental animals.

MATERIALS AND METHODS:
Ammonium glycyrrhizinate (50, 100, 200 mg/kg, p.o.) was administered for four weeks in albino rats. Cardiomyopathy was induced with a dose of 2.5 mg/kg i.p. of doxorubicin on 1(th), 7(th), 14(th), 21(th), 28(th) day in the experimental animals. At the end of the experiment, on 29(th) day, serum and heart tissues were collected and hemodynamic, biochemical and histopathological studies were carried out.

RESULTS:
Administration of doxorubicin in normal rats showed significant (P < 0.001) changes in body weight, feed intake, urine output, hemodynamic parameters like (blood pressure, heart rate, cardiac output) and in lipid profile (cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein) indicating cardiomyopathy symptoms. Animals treated with ammonium glycyrrhizinate significantly (P < 0.05) decreased triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels. Moreover, high density lipoprotein (HDL) levels increased in rats treated with ammonium glycyrrhizinate as compared with the normal group.

CONCLUSION:
Ammonium glycyrrhizinate is effective in controlling serum lipid profile and cardiac complications in experimentally induced cardiomyopathy in animals.

KEYWORDS

Ammonium glycyrrhizinate; cardiac failure; cardiomyopathy; doxorubicin

Title

Cardioprotective effect of ammonium glycyrrhizinate against doxorubicin-induced cardiomyopathy in experimental animals.

Author

Garg M1, Singhal T1, Sharma H1.

Publish date

2014 Sep-Oct


Description :

Monoammonium glycyrrhizinate hydrate has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.