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Amprolium hydrochloride

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1204

  • Specification : 98%(HPLC)

  • CAS number : 137-88-2

  • Formula : C14H20Cl2N4

  • Molecular Weight : 315.2

  • PUBCHEM ID : 8732

  • Volume : 5mg

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Catalogue Number

BN-O1204

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

315.2

Appearance

Botanical Source

Structure Type

Category

SMILES

CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.Cl.[Cl-]

Synonyms

mepyrium/AmproliumHclUsp27/thiacoccid/1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium Chloride Hydrochloride/AMPROLIUM HYDROCHLORIDE VETRANAL,250/AMPROLIUM HYDROCHLORIDE/Thiacoccide/Amprolium HCl/Amprolium (hydrochloride)

IUPAC Name

5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine;chloride;hydrochloride

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

PJBQYZZKGNOKNJ-UHFFFAOYSA-M

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:137-88-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29208764

Abstract

Thiamine plays a very important coenzymatic and non-coenzymatic role in the regulation of basic metabolism. Thiamine diphosphate is a coenzyme of many enzymes, most of which occur in prokaryotes. Pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes as well as transketolase are the examples of thiamine-dependent enzymes present in eukaryotes, including human. Therefore, thiamine is considered as drug or diet supplement which can support the treatment of many pathologies including neurodegenerative and vascular system diseases. On the other hand, thiamine antivitamins, which can interact with thiamine-dependent enzymes impeding their native functions, thiamine transport into the cells or a thiamine diphosphate synthesis, are good propose to drug design. The development of organic chemistry in the last century allowed the synthesis of various thiamine antimetabolites such as amprolium, pyrithiamine, oxythiamine, or 3-deazathiamine. Results of biochemical and theoretical chemistry research show that affinity to thiamine diphosphate-dependent enzymes of these synthetic molecules exceeds the affinity of native coenzyme. Therefore, some of them have already been used in the treatment of coccidiosis (amprolium), other are extensively studied as cytostatics in the treatment of cancer or fungal infections (oxythiamine and pyrithiamine). This review summarizes the current knowledge concerning the synthesis and mechanisms of action of selected thiamine antivitamins and indicates the potential of their practical use.

KEYWORDS

3-deazathiamine; amprolium; oxythiamine; pyrithiamine; thiamine.

Title

Thiamine and Selected Thiamine Antivitamins - Biological Activity and Methods of Synthesis

Author

Adam Tylicki 1, Zenon Łotowski 2, Magdalena Siemieniuk 1, Artur Ratkiewicz 3

Publish date

2018 Jan 10

PMID

30461003

Title

Optimizing Medical Management in Peripheral Artery Disease

Author

P A Coughlin 1, J H F Rudd 2

Publish date

2018 Aug;

PMID

31233476

Title

Acute Hemoptysis and Bronchoscopic Follow-up After Cryoablation of the Pulmonary Veins

Author

Lisa Basler 1, Charlotte Berlier 1, Gilles Straub 1, Jan Steffel 2, Daniel Franzen 1

Publish date

Jul-19


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