mepyrium/AmproliumHclUsp27/thiacoccid/1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium Chloride Hydrochloride/AMPROLIUM HYDROCHLORIDE VETRANAL,250/AMPROLIUM HYDROCHLORIDE/Thiacoccide/Amprolium HCl/Amprolium (hydrochloride)
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:137-88-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Thiamine plays a very important coenzymatic and non-coenzymatic role in the regulation of basic metabolism. Thiamine diphosphate is a coenzyme of many enzymes, most of which occur in prokaryotes. Pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes as well as transketolase are the examples of thiamine-dependent enzymes present in eukaryotes, including human. Therefore, thiamine is considered as drug or diet supplement which can support the treatment of many pathologies including neurodegenerative and vascular system diseases. On the other hand, thiamine antivitamins, which can interact with thiamine-dependent enzymes impeding their native functions, thiamine transport into the cells or a thiamine diphosphate synthesis, are good propose to drug design. The development of organic chemistry in the last century allowed the synthesis of various thiamine antimetabolites such as amprolium, pyrithiamine, oxythiamine, or 3-deazathiamine. Results of biochemical and theoretical chemistry research show that affinity to thiamine diphosphate-dependent enzymes of these synthetic molecules exceeds the affinity of native coenzyme. Therefore, some of them have already been used in the treatment of coccidiosis (amprolium), other are extensively studied as cytostatics in the treatment of cancer or fungal infections (oxythiamine and pyrithiamine). This review summarizes the current knowledge concerning the synthesis and mechanisms of action of selected thiamine antivitamins and indicates the potential of their practical use.
3-deazathiamine; amprolium; oxythiamine; pyrithiamine; thiamine.
Thiamine and Selected Thiamine Antivitamins - Biological Activity and Methods of Synthesis
Adam Tylicki 1, Zenon Łotowski 2, Magdalena Siemieniuk 1, Artur Ratkiewicz 3
2018 Jan 10
Optimizing Medical Management in Peripheral Artery Disease
P A Coughlin 1, J H F Rudd 2
Acute Hemoptysis and Bronchoscopic Follow-up After Cryoablation of the Pulmonary Veins
Lisa Basler 1, Charlotte Berlier 1, Gilles Straub 1, Jan Steffel 2, Daniel Franzen 1