Catalogue Number
BN-O1753
Analysis Method
Specification
98%(HPLC)
Storage
-20℃
Molecular Weight
244.3
Appearance
Cryst.
Botanical Source
This product is isolated and purified from the herbs of Cytisus scoparius
Structure Type
Category
SMILES
C1CCN2CC3CC(C2C1)CN4C3=CC=CC4=O
Synonyms
Anagyrin/Monolupine/3,4,5,6-Tetradehydrospartein-2-one/RHOMBININE/Alkaloid III/Rhombinin/Monolupin
IUPAC Name
Density
1.22 g/cm3
Solubility
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Flash Point
216.3ºC
Boiling Point
455.6ºC at 760 mmHg
Melting Point
InChl
InChl Key
FQEQMASDZFXSJI-JHJVBQTASA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:486-89-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
28494312
Anagyrine, a teratogenic quinolizidine alkaloid found in Lupinus spp., is proposed to undergo metabolism by pregnant cattle to a piperidine alkaloid which inhibits fetal movement, the putative mechanism behind crooked calf syndrome. The objective of this study was to test the hypothesis that anagyrine but not lupanine or sparteine can directly, without metabolism, desensitize nicotinic acetylcholine receptors (nAChR) in a cell culture model. SH-SY5Y cells expressing autonomic nAChR, and TE-671 cells expressing fetal muscle-type nAChR were exposed to lupine alkaloids or Dimethylphenylpiperazinium (DMPP) in log10 molar increments from 10nM to 100μM and then to a fixed concentration of acetylcholine (ACh) (10μM for SH-SY5Y cells and 1μM for TE-671 cells) and the responses measured with a membrane potential sensing dye to assess nAChR activation and desensitization. The selective ganglionic nAChR agonist DMPP used as a positive control, was a potent activator and desensitizer of nAChR expressed by SH-SY5Y cells. Lupanine was a weak agonist and desensitizer in SH-SY5Y cells and sparteine was without effect. Anagyrine acted as a partial agonist in both cell lines with EC50 values of 4.2 and 231μM in SH-SY5Y and TE-671 cells, respectively. Anagyrine was a desensitizer of nAChR with DC50 values of 6.9 and 139μM in SH-SY5Y and TE-671 cells, respectively. These results confirm the hypothesis that anagyrine is a potent and effective desensitizer of nAChR, and that anagyrine can directly, without metabolism, desensitize nAChR. Moreover, serum anagyrine concentrations may be a potential biomarker for lupine teratogenicity in cattle.
Published by Elsevier Ltd.
Anagyrine; Biomarker; DMPP; Lupanine; Sparteine; nAChR
Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle.
Green BT1, Lee ST2, Welch KD2, Cook D2.
2017 Dec
3110390
Anagyrine-induced red cell aplasia, vascular anomaly, and skeletal dysplasia.
Ortega JA, Lazerson J.
1987 Jul
3339518
Anagyrine-induced congenital defects.
Finnell RH, Chernoff GF.
1988 Feb