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Anethole, trans-


  • Brand : BIOFRON

  • Catalogue Number : AV-P10271

  • Specification : 98%

  • CAS number : 4180-23-8

  • Formula : C10H12O

  • Molecular Weight : 148.2

  • PUBCHEM ID : 637563

  • Volume : 0.1ml

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Catalogue Number


Analysis Method






Molecular Weight



Light yellow liquid

Botanical Source

Illicium verum

Structure Type

Simple Phenylpropanoids


Standards;Natural Pytochemical;API




4-Propenylanisole (trans-1-Methoxy-4-(1-propenyl)benzene/trans-isoestragole/trans-p-Propenylanisole/4-Propenylanisole/trans-anisol/trans-p-Methoxypropenylbenzene/trans-methylchavicol/Anise camphor/trans-Anethol/Anethole/trans-1-Methoxy-4-(1-propenyl)benzene/anis camphor/(E)-1-Methoxy-4-(prop-1-en-1-yl)benzene/ANETHOLUM







Flash Point


Boiling Point


Melting Point



InChl Key

WGK Germany


HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:4180-23-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.


Hypertension; Nicotine; Restraint; Stress; Trans-anethole.


Trans-anethole Prevents Hypertension Induced by Chronic Exposure to Both Restraint Stress and Nicotine in Rats


Eunhye Seo 1 , Purum Kang 1 , Geun Hee Seol 2

Publish date

2018 Jun




Transient receptor potential (TRP) cation channels are molecular targets of various natural products. TRPA1, a member of TRP channel family, is specifically activated by natural products such as allyl isothiocyanate (mustard oil), cinnamaldehyde (cinnamon), and allicin (garlic). In this study, we demonstrated that TRPA1 is also a target of trans-anethole in fennel oil (FO) and fennel seed extract. Similar to FO, trans-anethole selectively elicited calcium influx in TRPA1-expressing mouse sensory neurons of the dorsal root and trigeminal ganglia. These FO- and anethole-induced calcium responses were blocked by a selective TRPA1 channel antagonist, HC-030031. Moreover, both FO and trans-anethole induced calcium influx and transmembrane currents in HEK293 cells stably overexpressing human TRPA1 channels, but not in regular HEK293 cells. Mutation of the amino acids S873 and T874 binding site of human TRPA1 significantly attenuated channel activation by trans-anethole, whereas pretreating with glutathione, a nucleophile, did not. Conversely, activation of TRPA1 by the electrophile allyl isothiocyanate was abolished by glutathione, but was ostensibly unaffected by mutation of the ST binding site. Finally, it was found that trans-anethole was capable of desensitizing TRPA1, and unlike allyl isothiocyanate, it failed to induce nocifensive behaviors in mice. We conclude that trans-anethole is a selective, nonelectrophilic, and seemingly less-irritating agonist of TRPA1.
Copyright ? 2019 by The American Society for Pharmacology and Experimental Therapeutics.


Hypertension; Nicotine; Restraint; Stress; Trans-anethole.


trans-Anethole of Fennel Oil Is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel


Tosifa Memon 1 , Oleg Yarishkin 2 , Christopher A Reilly 2 , David Kri?aj 2 , Baldomero M Olivera 2 , Russell W Teichert 2

Publish date

2019 Apr




The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI), which, when reacting with hepatic proteins proved to cause irreversible lesions. Associated with this process, an intense inflammatory process is also evidenced, characterized by the increased cell influx and production/release of inflammatory mediators. Trans anethole, an aromatic compounds has been showed anti-inflammatory efficacy by inhibit the cellular recruitment and synthesis/releases of many proinflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitrico oxide (NO). The aim of this study is to investigate the effect of trans anethole on some inflammatory parameters that are involved in hepatotoxicity induced by high doses of acetaminophen. Our results demonstrate that treatment with AN at doses 125 and 250mg/kg once a day for seven days prevented the changes caused by the APAP overdose, showing less intensity in the histological changes (necrosis, size of hepatocyte area and inflammatory infiltration), and corroborating the findings of serum activities of transaminases and phosphatases and the activity of the enzyme myeloperoxidase. In addition, the treatment prevented the up-regulation of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10). Thus, our results demonstrate a possible protective effect of trans anethole on the hepatotoxicity induced by APAP.


Acetaminophen; Hepatoprotection; Trans anethole.


Acetaminophen-induced Hepatotoxicity: Preventive Effect of Trans Anethole


Bruno Ambrosio da Rocha 1 , Alessandra M Versuti Ritter 2 , Franciele Queiroz Ames 3 , Odinei Hess Goncalves 4 , Fernanda Vitoria Leimann 5 , Livia Bracht 6 , Maria Raquel Marcal Natali 7 , Roberto Kenji Nakamura Cuman 8 , Ciomar Ap Bersani-Amado 9

Publish date

2017 Feb

Description :

Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Pimpinella, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines[1][2]. Trans-Anethole ((E)-Anethole) contributes a large component of the odor and flavor of anise and fennel, anise myrtle, liquorice, camphor, magnolia blossoms, and star anise[3].