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Angeloylgomisin H

$300

  • Brand : BIOFRON

  • Catalogue Number : BF-A4011

  • Specification : 97%(HPLC)

  • CAS number : 66056-22-2

  • Formula : C28H36O8

  • Molecular Weight : 500.58

  • PUBCHEM ID : 26204131

  • Volume : 20mg

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Catalogue Number

BF-A4011

Analysis Method

HPLC,NMR,MS

Specification

97%(HPLC)

Storage

-20℃

Molecular Weight

500.58

Appearance

White powder

Botanical Source

Schisandra chinensis,Schisandra neglecta

Structure Type

Lignanoids

Category

Standards;Natural Pytochemical;API

SMILES

CC=C(C)C(=O)OC1=C2C(=CC(=C1OC)OC)CC(C(CC3=CC(=C(C(=C32)OC)OC)OC)(C)O)C

Synonyms

Angeloylgomisin H/(6S,7S)-7-Hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-1-yl (2Z)-2-methyl-2-butenoate/2-Butenoic acid, 2-methyl-, (6S,7S)-5,6,7,8-tetrahydro-7-hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-1-yl ester, (2Z)-

IUPAC Name

[(9S,10S)-10-hydroxy-4,5,14,15,16-pentamethoxy-9,10-dimethyl-3-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaenyl] (Z)-2-methylbut-2-enoate

Density

1.1±0.1 g/cm3

Solubility

Methanol; Acetone; Ethyl Acetate

Flash Point

212.3±25.0 °C

Boiling Point

656.3±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C28H36O8/c1-10-15(2)27(29)36-26-21-17(12-19(31-5)24(26)34-8)11-16(3)28(4,30)14-18-13-20(32-6)23(33-7)25(35-9)22(18)21/h10,12-13,16,30H,11,14H2,1-9H3/b15-10-/t16-,28-/m0/s1

InChl Key

ZSAUXCVJDYCLRS-XSIRQHFTSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:66056-22-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

26770391

Abstract

Angeloylgomisin H, as a major lignin in the fruits, was reported to have the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ. In this work, a sensitive and selective UPLC-MS/MS method for determination of angeloylgomisin H in rat plasma is developed. After addition of rutin as an internal standard (IS), protein precipitation by acetonitrile was used to prepare samples. Chromatographic separation was achieved on a UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) with 0.1% formic acid and acetonitrile as the mobile phase with gradient elution. An electrospray ionization source was applied and operated in positive ion mode; multiple reactions monitoring (MRM) mode was used for quantification using target fragment ions m/z 523.2-315.1 for angeloylgomisin H, and m/z 611.1-303.1 for IS. Calibration plots were linear throughout the range 5-2000 ng/mL for angeloylgomisin H in rat plasma. Mean recoveries of angeloylgomisin H in rat plasma ranged from 86.2% to 92.5%. RSD of intra-day and inter-day precision were both < 11%. The accuracy of the method was between 93.0% and 104.1%. The method was successfully applied to pharmacokinetic study of angeloylgomisin H after either oral or intravenous administration. The absolute bioavailability of angeloylgomisin H was reported as high as 4.9%.

KEYWORDS

Angeloylgomisin H; UPLC-MS/MS; pharmacokinetics; rat plasma

Title

Pharmacokinetic and bioavailability study of angeloylgomisin H in rat plasma by UPLC-MS/MS.

Author

Chen S1, Jia Z1, Dong L2, Geng P3, Liu Z4, Yang S4, Wen C4, Liu F2.

Publish date

2015 Oct 15


Description :

Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ[1].