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Anthraquinone-1,5-disulfonic acid disodium salt

$77

  • Brand : BIOFRON

  • Catalogue Number : BN-O1069

  • Specification : 98%(HPLC)

  • CAS number : 853-35-0

  • Formula : C14H6Na2O8S2

  • Molecular Weight : 412.3

  • PUBCHEM ID : 70067

  • Volume : 5mg

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Catalogue Number

BN-O1069

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

412.3

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC2=C(C(=C1)S(=O)(=O)[O-])C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)[O-].[Na+].[Na+]

Synonyms

disodium,9,10-dioxoanthracene-1,5-disulfonate/Disodium 9,10-dioxo-9,10-dihydro-1,5-anthracenedisulfonate/disodium 9,10-dioxo-9,10-dihydroanthracene-1,5-disulfonate/1,5-Anthracenedisulfonic acid, 9,10-dihydro-9,10-dioxo-, sodium salt (1:2)

IUPAC Name

disodium;9,10-dioxoanthracene-1,5-disulfonate

Density

Solubility

Flash Point

Boiling Point

Melting Point

>300°C

InChl

InChl Key

OFASSSMJNCWWTP-UHFFFAOYSA-L

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:853-35-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

23129048

Abstract

JTK-853, a palm site-binding NS5B nonnucleoside polymerase inhibitor, shows antiviral activity in vitro and in hepatitis C virus (HCV)-infected patients. Here, we report the results of genotypic and phenotypic analyses of resistant variants in 24 HCV genotype 1-infected patients who received JTK-853 (800, 1,200, or 1,600 mg twice daily or 1,200 mg three times daily) in a 3-day monotherapy. Viral resistance in NS5B was investigated using HCV RNA isolated from serum specimens from the patients. At the end of treatment (EOT) with JTK-853, the amino acid substitutions M414T (methionine [M] in position 414 at baseline was replaced with threonine [T] at EOT), C445R (cysteine [C] in position 445 at baseline was replaced with arginine [R] at EOT), Y448C/H (tyrosine [Y] in position 448 at baseline was replaced with cysteine [C] or histidine [H] at EOT), and L466F (leucine [L] in position 466 at baseline was replaced with phenylalanine [F] at EOT), which are known to be typical resistant variants of nonnucleoside polymerase inhibitors, were observed in a clonal sequencing analysis. These substitutions were also selected by a treatment with JTK-853 in vitro, and the 50% effective concentration of JTK-853 in the M414T-, C445F-, Y448H-, and L466V-harboring replicons attenuated the susceptibility by 44-, 5-, 6-, and 21-fold, respectively, compared with that in the wild-type replicon (Con1). These findings suggest that amino acid substitutions of M414T, C445R, Y448C/H, and L466F are thought to be viral resistance mutations in HCV-infected patients receiving JTK-853 in a 3-day monotherapy.

Title

Genotypic and Phenotypic Analyses of Hepatitis C Virus from Patients Treated with JTK-853 in a Three-Day Monotherapy

Author

Naoki Ogura,a Yukiyo Toyonaga,a Izuru Ando,a Kunihiro Hirahara,b Tsutomu Shibata,b Gabriela Turcanu,c Sudhakar Pai,c Kan Yee,c Barbara Gerhardt,c Maribel Rodriguez-Torres,d and Toru Noguchicorresponding authora

Publish date

2013 Jan;

PMID

22006673

Abstract

Accurate knowledge of haplotypes, the combination of alleles co-residing on a single copy of a chromosome, enables powerful gene mapping and sequence imputation methods. Since humans are diploid, haplotypes must be derived from genotypes by a phasing process. In this study, we present a new computational model for haplotype phasing based on pairwise sharing of haplotypes inferred to be Identical-By-Descent (IBD). We apply the Bayesian network based model in a new phasing algorithm, called systematic long-range phasing (SLRP), that can capitalize on the close genetic relationships in isolated founder populations, and show with simulated and real genome-wide genotype data that SLRP substantially reduces the rate of phasing errors compared to previous phasing algorithms. Furthermore, the method accurately identifies regions of IBD, enabling linkage-like studies without pedigrees, and can be used to impute most genotypes with very low error rate. Genet. Epidemiol. 2011. © 2011 Wiley Periodicals, Inc.35:853-860, 2011

KEYWORDS

haplotype, population isolate, long-range phasing, Bayesian network

Title

Identity-by-Descent-Based Phasing and Imputation in Founder Populations Using Graphical Models

Author

Kimmo Palin,1 Harry Campbell,2 Alan F Wright,3 James F Wilson,2 and Richard Durbin1,*

Publish date

2011 Dec

Title

ESICM LIVES 2016: part two Milan, Italy. 1-5 October 2016

Publish date

2016 Sep 29


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