Indolo[2,3-a]quinolizine-2-ethanol, β-ethenyl-1,2,3,4,6,7,12,12b-octahydro-, (βR,2S,12bS)-/(2R)-2-[(2S,12bS)-1,2,3,4,6,7,12,12b-Octahydroindolo[2,3-a]quinolizin-2-yl]-3-buten-1-ol
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
488.2±40.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:16049-28-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Information comparing subjective and objective measurements of adherence to study medications and the effects of adherence on treatment-related differences in asthma clinical trials are limited.
We sought to compare subjective and objective measurements of children’s adherence to inhaled corticosteroids or placebo and to determine whether adherence to study medications modified treatment-related differences in outcomes.
In an ancillary study conducted in 3 of 8 Childhood Asthma Management Program Clinical Centers, adherence was assessed by using self-reported and objective data in 5- to 12-year-old children with mild or moderate asthma who were randomly assigned to 200 μg of inhaled budesonide twice per day (n = 84) or placebo (n = 56) for 4 years. The κ statistic was used to evaluate agreement between self-reported adherence (daily diary cards) and objectively measured adherence (number of doses left in study inhalers). Multivariable analyses were used to determine whether adherence to study treatment modified treatment-related differences in outcomes.
Adherence of less than 80% was seen in 75% of 140 children when adherence was measured objectively but only in 6% of children when measured by means of self-report. There was poor agreement between objective and subjective measurements of adherence of at least 80% (κ = 0.00; 95% CI, ?0.05 to 0.04); self-reported adherence over the 4-year period generally overestimated objectively measured adherence (93.6% vs 60.8%, P < .0001). There was little evidence to indicate that adherence modified treatment-related differences in outcomes. Conclusion Researchers should use objective rather than self-reported adherence data to identify clinical trial participants with low levels of adherence to study treatment.
Asthma, adherence, compliance, children, lung growth, inhaled corticosteroids, budesonide, clinical trial
Adherence to inhaled corticosteroids: An ancillary study of the Childhood Asthma Management Program clinical trial
Jerry A. Krishnan, MD, PhD,a Bruce G. Bender, PhD,b Frederick S. Wamboldt, MD,b Stanley J. Szefler, MD,b N. Franklin Adkinson, Jr, MD,c Robert S. Zeiger, MD, PhD,d Robert A. Wise, MD,c Andrew L. Bilderback, MS,c and Cynthia S. Rand, PhDc, on behalf of the Adherence Ancillary Study Group*
2013 Jan 1.
Despite the potential role of chitinases and chitinase-like proteins in the pathogenesis of asthma, variants in their respective genes are not associated with asthma, changes in lung physiology or allergy-related phenotypes in Caucasian children.
chitinase, chitinase-like protein, CHIA, CHIT1, CHI13L1, YKL-40, AMCase, SNPs, asthma
Polymorphisms of Chitinases are not Associated with Asthma
Ann Chen Wu, MD, MPH,1,2,3 Jessica Lasky-Su, PhD,4 Christine A. Rogers, PhD,5 Barbara J. Klanderman, PhD,3 and Augusto Litonjua, MD, MPH3,4,6
2011 Mar 1.
We experimentally perform the simulation of open quantum dynamics in single-qudit systems. Using a spatial light modulator as a dissipative optical device, we implement dissipative-dynamical maps onto qudits encoded in the transverse momentum of spontaneous parametric down-converted photon pairs. We show a well-controlled technique to prepare entangled qudits states as well as to implement dissipative local measurements; the latter realize two specific dynamics: dephasing and amplitude damping. Our work represents a new analogy-dynamical experiment for simulating an open quantum system.
Experimental simulation of decoherence in photonics qudits
B. Marques,a,1,2 A. A. Matoso,1 W. M. Pimenta,1 A. J. Gutierrez-Esparza,1 M. F. Santos,1 and S. Padua1