Apium graveolens var.dulce/Found free or as glycosides in the stems, roots, leaves, seeds or fruit of a very wide range of plant spp. Found also in some fossil leaf tissues
5,7,4'-trihydroxyflavone/apigenol/Versuline/Versulin/262620/4',5,7-Trihydroxyflavone/CHAMOMILE/Celery seed extract/C.I. NATURAL YELLOW 1/T66 BO EVJ CR DQ& GQ IQ/Apigenine/4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-/5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one/Apigenin/Pelargidenone
Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
555.5±50.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:520-36-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Apigenin, a natural flavone, is widely distributed in plants such as celery, parsley and chamomile. It is present principally as glycosylated in nature. Higher intake of apigenin could reduce the risk of chronic diseases. It has gained particular interest in recent years as a beneficial, health-promoting agent with low intrinsic toxicity. Areas covered: This review summarizes and the absorption, distribution, metabolism and excretion (ADME) properties of apigenin, and drug-drug interaction of apigenin. Expert opinion: Since apigenin is a bioactive plant flavone and is widely distributed in common food, its consumption through the diet is recommended. Apigenin-enriched drugs are better for some chronic diseases, but may affect animal and human health if present in the daily diet. Dietary or therapeutic apigenin has value as a good cellular regulator in cancer, especially cancers of the gastrointestinal tract. Due to apigenin’s limitations on absorption and bioavailability, novel carriers would need to be developed to enhance the oral bioavailability of apigenin. Further research about its ADME properties and drug-drug interactions are needed before apigenin can be brought to clinical trials.
ADME; Apigenin; interaction; pharmacokinetic
Pharmacokinetic properties and drug interactions of apigenin, a natural flavone.
Tang D1, Chen K1, Huang L1,2, Li J1,2.
Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer’s disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin’s key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.
apigenin; cancer; chronic diseases; diabetes; flavonoids
The Therapeutic Potential of Apigenin.
Salehi B1, Venditti A2, Sharifi-Rad M3, Kręgiel D4, Sharifi-Rad J5, Durazzo A6, Lucarini M7, Santini A8, Souto EB9,10, Novellino E11, Antolak H12, Azzini E13, Setzer WN14, Martins N15,16.
2019 Mar 15
Neurodegenerative disorders (NDDs) such as Alzheimer’s and Parkinson’s diseases are the most common age-related pathologies that affect millions of people all over the world. To date, effective therapy for NDDs is not available and current approaches to disease management include neuroprotection strategy with a hope of maintaining and enhancing the function of survising neurons. Of course, such an approach by its own will not offer a cure but is likely to delay the disease progression by ameliorating the increase of neurotoxic agents such reactive oxygen species (ROS) as well as the associated inflammatory cascades. In this regard, natural products including flavonods that offer neuroprotection through multiple mechanisms have gained a lot of interest in recent years. In this communication, evidences from the various experimental models and clinical trials on the therapeutic potential of one promising flavonod, apigenin, is presented. Its chemistry, mechanism of action and potential benefits in the various examples of NDDs are discussed in the light of drug discovery aspects.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Alzheimer’s disease; Apigenin; Flavonoids; Neuroprotection; Parkinson’s disease
Apigenin as neuroprotective agent: Of mice and men.
Nabavi SF1, Khan H2, D'onofrio G3, Šamec D4, Shirooie S5, Dehpour AR6, Arguelles S7, Habtemariam S8, Sobarzo-Sanchez E9.