We Offer Worldwide Shipping
Login Wishlist

Arbutin

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0006

  • Specification : 98.0%(HPLC)

  • CAS number : 497-76-7

  • PUBCHEM ID : 440936

  • Volume : 25mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BD-P0006

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

Appearance

White needle crystal

Botanical Source

pear leaves (Pyrus communis). Widespread in the Ericaceae, also found in many other plants. First Arctostaphylos uva-ursi in 1852

Structure Type

Simple Phenolic Compounds

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O

Synonyms

Ericolin)/4-Hydroxyphenyl β-D-glucopyranoside/Uresol/Hydroquinone-β-D-glucoside/Hydroquinone-b-D-glucopyranoside/p-Hydroxyphenyl β-D-glucopyranoside/Hydroquinone-β-D-glucopyranoside/Hydroquinoneβ-D-glucopyranoside/hydroquinone O-beta-D-glucopyranoside/UVASOL/Arbutosie/5-17-07-00110/P-ARBUTIN/β-D-Glucopyranoside, 4-hydroxyphenyl/4-Hydroxyphenyl-β-D-glucopyranosidep/4-Hydroxyphenyl-β-glucopyranoside/4-Hydroxyphenyl Beta-D-Glucopyranoside/(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol/b-Arbutin/Arbutin/4-Hydroxyphenyl-β-D-glucopyranoside/hydroquinone O-β-D-glucopyranoside/URSIN/(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol/4-Hydroxyphenyl-b-D-glucopyranoside/ARBUTOSIDE

IUPAC Name

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol

Density

1.6±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

293.4±30.1 °C

Boiling Point

561.6±50.0 °C at 760 mmHg

Melting Point

195-198 °C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:497-76-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31485892

Abstract

Arbutin is a glycoside reported for its anti-oxidant, anti-inflammatory and anti-tumor properties. However, the cardioprotective effect of Arbutin is not well established. The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice. The animals were pretreated with Arbutin for a week and ISO was administered for 10 days and then sacrificed. Cardiac injury markers such as creatinine kinase and lactate dehydrogenase concentrations were measured in the serum. The mRNA expression of cardiac hypertrophy markers namely atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were measured using qRT-PCR. The levels of pro-inflammatory cytokines TNF-α and IL-6 were quantified by ELISA in isolated tissues and serum. Other tissue anti-oxidant parameters such as GST, GSH, SOD and TBARS were also measured. TUNEL assay was performed to detect apoptosis. Histology studies were performed using H & E and Masson trichome staining. Immunoblot analysis was used to quantify the protein expression of TLR-4 and NF-κB. ISO-alone-treated group showed significant increase in CK-MB, LDH along with increase in hypertrophic markers ANP and BNP, TNF-α and IL-6 levels in serum and tissues and increased cardiomyocyte apoptosis. Anti-oxidant parameters were significantly decreased and TLR-4 and NF-κB protein expression was found to be upregulated in comparison to the control group. Pretreatment with Arbutin-exhibited significant inhibition of TLR-4/NF-κB pathway with decreased levels of pro-inflammatory cytokines and enhanced myocardial anti-oxidant status. Our study demonstrated that pretreatment with Arbutin exhibits marked protective effects on ISO-induced cardiac hypertrophy in mice. Thus, Arbutin may be used as potential pharmacological interventions in the management of cardiac hypertrophy.

KEYWORDS

Arbutin; Cardiac hypertrophy; Isoproterenol; TLR-4/NF-κB pathway

Title

Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice.

Author

Nalban N1,2, Sangaraju R1,2, Alavala S1, Mir SM1, Jerald MK3, Sistla R4,5.

Publish date

2019 Sep 4

PMID

31379179

Abstract

AIM:
Oxidative and nitrosative stress triggers an extensive damage to the tissues. Many herbal and chemical medicines have claimed to possess antioxidant properties. Arbutin exists in some plants such as Pyrus Biossierana Bushe. In this study, an inhibitory effect of arbutin against tert-butyl hydroperoxide induced cytotoxicity was studied using SYTOX TM Green assay for cell viability. The antioxidant effects of arbutin on the generation of malondialdehyde, nitric oxide, activity of oxidative enzyme (Superoxide dismutase and catalyze) and the amount of total thiol in Hep-G2 cells exposed to tert-butyl hydroperoxide were evaluated.

METHODS:
Hep-G2 cells were cultured in 24-well plates. After 24 hours, the cells were pretreated with the arbutin at different concentrations (0, 100 and 150 µM). 24 hours later, tert-butyl hydroperoxide at different concentrations (0, 150, 200 and 250 µM) was added into the culture media.

RESULTS:
Arbutin was able to decrease malondialdehyde and nitric oxide concentrations in arbutin treated group in comparison with the control group (p < 0.00001). The catalase and superoxide dismutase enzymes in these cells were significantly decreased in a dose depend manner in the presence of arbutin in comparison with the control group (p < 0.00001). In addition, arbutin was capable of increasing the tert-butyl hydroperoxide mediated reduction in the total thiol amount in comparison with the control group (p < 0.00001.) CONCLUSION: Our investigation demonstrated that tert-butyl hydroperoxide evoked a reactive oxygen and nitrogen species overproduction in Hep-G2 cells. The cells treated with arbutin showed a dose-dependent reduction of tert-butyl hydroperoxide induced reactive oxygen and nitrogen species generation (Fig. 6, Ref. 34).

KEYWORDS

arbutin; nitrosative stress; oxidative stress; tert-butyl hydroperoxide Hep-G2 cell line.

Title

Is arbutin an effective antioxidant for the discount of oxidative and nitrosative stress in Hep-G2 cells exposed to tert-butyl hydroperoxide?

Author

Seyfizadeh N, Tazehkand MQ, Palideh A, Maroufi NF, Hassanzadeh D, Rahmati-Yamchi M, Elahimanesh F, Borzoueisileh S.

Publish date

2019

PMID

31319730

Abstract

Arbutin (ARB) has been widely used in skin pigmentation disorders. Nevertheless, the involvements of ARB in diabetic nephropathy (DN) are still unknown. We investigated the functions of ARB in high glucose (HG)-induced cell apoptosis and autophagy in HK-2 cells. Cell viability was examined through CCK-8 in HK-2 cells after disposal with 45 mM glucose and ARB (10-50 μM). Flow cytometry and western blot tested cell apoptosis and the related protein levels in HK-2 cells after 45 mM glucose and 50 μM ARB administration. RT-qPCR delved microRNA (miR)-27a expression in HG and ARB co-treated HK-2 cells. Effect of miR-27a on ARB affected cell apoptosis and autophagy was investigated after miR-27a inhibitor transfection. JNK and mTOR pathways were finally assessed by western blot. ARB alleviated HG-induced cell apoptosis, autophagy and regulated the related protein levels in HK-2 cells. MiR-27a expression was reduced in HG-treated cells, but was accelerated in HG and ARB co-treated HK-2 cells with the increased concentration. Inhibition of miR-27a apparently abolished the outcomes of ARB in HG-induced HK-2 cells apoptosis and autophagy. Besides, ARB blocked JNK and mTOR pathways by regulating miR-27a. The findings demonstrated that ARB alleviated apoptosis and autophagy in HG-treated HK-2 cells by regulating miR-27a/JNK/mTOR axis.

KEYWORDS

Diabetic nephropathy; JNK; arbutin; mTOR; microRNA-27a

Title

Arbutin protects HK-2 cells against high glucose-induced apoptosis and autophagy by up-regulating microRNA-27a.

Author

Lv L1,2, Zhang J3, Tian F4, Li X1, Li D3, Yu X1.

Publish date

2019 Dec


Description :

Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.IC50 value:Target: tyrosinase