We Offer Worldwide Shipping
Login Wishlist



Catalogue Number : BD-P0006
Specification : 98.0%(HPLC)
CAS number : 497-76-7
PUBCHEM ID : 440936
Volume : 25mg

Available on backorder

Checkout Bulk Order?

Catalogue Number


Analysis Method






Molecular Weight


White needle crystal

Botanical Source

pear leaves (Pyrus communis). Widespread in the Ericaceae, also found in many other plants. First Arctostaphylos uva-ursi in 1852

Structure Type

Simple Phenolic Compounds


Standards;Natural Pytochemical;API




Ericolin)/4-Hydroxyphenyl β-D-glucopyranoside/Uresol/Hydroquinone-β-D-glucoside/Hydroquinone-b-D-glucopyranoside/p-Hydroxyphenyl β-D-glucopyranoside/Hydroquinone-β-D-glucopyranoside/Hydroquinoneβ-D-glucopyranoside/hydroquinone O-beta-D-glucopyranoside/UVASOL/Arbutosie/5-17-07-00110/P-ARBUTIN/β-D-Glucopyranoside, 4-hydroxyphenyl/4-Hydroxyphenyl-β-D-glucopyranosidep/4-Hydroxyphenyl-β-glucopyranoside/4-Hydroxyphenyl Beta-D-Glucopyranoside/(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol/b-Arbutin/Arbutin/4-Hydroxyphenyl-β-D-glucopyranoside/hydroquinone O-β-D-glucopyranoside/URSIN/(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol/4-Hydroxyphenyl-b-D-glucopyranoside/ARBUTOSIDE




1.6±0.1 g/cm3


Methanol; DMSO

Flash Point

293.4±30.1 °C

Boiling Point

561.6±50.0 °C at 760 mmHg

Melting Point

195-198 °C


InChl Key

WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:497-76-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Arbutin is a glycoside reported for its anti-oxidant, anti-inflammatory and anti-tumor properties. However, the cardioprotective effect of Arbutin is not well established. The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice. The animals were pretreated with Arbutin for a week and ISO was administered for 10 days and then sacrificed. Cardiac injury markers such as creatinine kinase and lactate dehydrogenase concentrations were measured in the serum. The mRNA expression of cardiac hypertrophy markers namely atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were measured using qRT-PCR. The levels of pro-inflammatory cytokines TNF-α and IL-6 were quantified by ELISA in isolated tissues and serum. Other tissue anti-oxidant parameters such as GST, GSH, SOD and TBARS were also measured. TUNEL assay was performed to detect apoptosis. Histology studies were performed using H & E and Masson trichome staining. Immunoblot analysis was used to quantify the protein expression of TLR-4 and NF-κB. ISO-alone-treated group showed significant increase in CK-MB, LDH along with increase in hypertrophic markers ANP and BNP, TNF-α and IL-6 levels in serum and tissues and increased cardiomyocyte apoptosis. Anti-oxidant parameters were significantly decreased and TLR-4 and NF-κB protein expression was found to be upregulated in comparison to the control group. Pretreatment with Arbutin-exhibited significant inhibition of TLR-4/NF-κB pathway with decreased levels of pro-inflammatory cytokines and enhanced myocardial anti-oxidant status. Our study demonstrated that pretreatment with Arbutin exhibits marked protective effects on ISO-induced cardiac hypertrophy in mice. Thus, Arbutin may be used as potential pharmacological interventions in the management of cardiac hypertrophy.


Arbutin; Cardiac hypertrophy; Isoproterenol; TLR-4/NF-κB pathway


Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice.


Nalban N1,2, Sangaraju R1,2, Alavala S1, Mir SM1, Jerald MK3, Sistla R4,5.

Publish date

2019 Sep 4




Oxidative and nitrosative stress triggers an extensive damage to the tissues. Many herbal and chemical medicines have claimed to possess antioxidant properties. Arbutin exists in some plants such as Pyrus Biossierana Bushe. In this study, an inhibitory effect of arbutin against tert-butyl hydroperoxide induced cytotoxicity was studied using SYTOX TM Green assay for cell viability. The antioxidant effects of arbutin on the generation of malondialdehyde, nitric oxide, activity of oxidative enzyme (Superoxide dismutase and catalyze) and the amount of total thiol in Hep-G2 cells exposed to tert-butyl hydroperoxide were evaluated.

Hep-G2 cells were cultured in 24-well plates. After 24 hours, the cells were pretreated with the arbutin at different concentrations (0, 100 and 150 µM). 24 hours later, tert-butyl hydroperoxide at different concentrations (0, 150, 200 and 250 µM) was added into the culture media.

Arbutin was able to decrease malondialdehyde and nitric oxide concentrations in arbutin treated group in comparison with the control group (p < 0.00001). The catalase and superoxide dismutase enzymes in these cells were significantly decreased in a dose depend manner in the presence of arbutin in comparison with the control group (p < 0.00001). In addition, arbutin was capable of increasing the tert-butyl hydroperoxide mediated reduction in the total thiol amount in comparison with the control group (p < 0.00001.) CONCLUSION: Our investigation demonstrated that tert-butyl hydroperoxide evoked a reactive oxygen and nitrogen species overproduction in Hep-G2 cells. The cells treated with arbutin showed a dose-dependent reduction of tert-butyl hydroperoxide induced reactive oxygen and nitrogen species generation (Fig. 6, Ref. 34).


arbutin; nitrosative stress; oxidative stress; tert-butyl hydroperoxide Hep-G2 cell line.


Is arbutin an effective antioxidant for the discount of oxidative and nitrosative stress in Hep-G2 cells exposed to tert-butyl hydroperoxide?


Seyfizadeh N, Tazehkand MQ, Palideh A, Maroufi NF, Hassanzadeh D, Rahmati-Yamchi M, Elahimanesh F, Borzoueisileh S.

Publish date





Arbutin (ARB) has been widely used in skin pigmentation disorders. Nevertheless, the involvements of ARB in diabetic nephropathy (DN) are still unknown. We investigated the functions of ARB in high glucose (HG)-induced cell apoptosis and autophagy in HK-2 cells. Cell viability was examined through CCK-8 in HK-2 cells after disposal with 45 mM glucose and ARB (10-50 μM). Flow cytometry and western blot tested cell apoptosis and the related protein levels in HK-2 cells after 45 mM glucose and 50 μM ARB administration. RT-qPCR delved microRNA (miR)-27a expression in HG and ARB co-treated HK-2 cells. Effect of miR-27a on ARB affected cell apoptosis and autophagy was investigated after miR-27a inhibitor transfection. JNK and mTOR pathways were finally assessed by western blot. ARB alleviated HG-induced cell apoptosis, autophagy and regulated the related protein levels in HK-2 cells. MiR-27a expression was reduced in HG-treated cells, but was accelerated in HG and ARB co-treated HK-2 cells with the increased concentration. Inhibition of miR-27a apparently abolished the outcomes of ARB in HG-induced HK-2 cells apoptosis and autophagy. Besides, ARB blocked JNK and mTOR pathways by regulating miR-27a. The findings demonstrated that ARB alleviated apoptosis and autophagy in HG-treated HK-2 cells by regulating miR-27a/JNK/mTOR axis.


Diabetic nephropathy; JNK; arbutin; mTOR; microRNA-27a


Arbutin protects HK-2 cells against high glucose-induced apoptosis and autophagy by up-regulating microRNA-27a.


Lv L1,2, Zhang J3, Tian F4, Li X1, Li D3, Yu X1.

Publish date

2019 Dec