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Ardisiacrispin A

$896

  • Brand : BIOFRON

  • Catalogue Number : BD-P0769

  • Specification : 98.5%(HPLC)

  • CAS number : 23643-61-0

  • Formula : C52H84O22

  • Molecular Weight : 1061.22

  • PUBCHEM ID : 10328746

  • Volume : 25mg

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Catalogue Number

BD-P0769

Analysis Method

HPLC,NMR,MS

Specification

98.5%(HPLC)

Storage

2-8°C

Molecular Weight

1061.22

Appearance

White powder

Botanical Source

Ardisia crispa

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2CCC3(C(C2(CCC1OC4C(C(C(CO4)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(CO6)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)C)CCC89C3(CC(C1(C8CC(CC1)(C)C=O)CO9)O)C)C)C

Synonyms

Ardisiacrispin A

IUPAC Name

(1S,2R,4S,5R,8R,10S,13R,14R,17S,18R,20S)-10-[(2S,3R,4S,5S)-5-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-hydroxy-4,5,9,9,13,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosane-20-carbaldehyde

Applications

Ardisiacrispin A (Deglucocyclamin) is a common triterpenoid saponin from Ardisia species. Ardisiacrispin A has similar biological properties with some triterpenoid saponins in A. crenata which is one of the species of genus Ardisia and exhibits cytotoxic effect on tumor cells, immunomodulatory and antiviral activities[1].

Density

1.48±0.1 g/cm3 (20 ºC 760 Torr)

Solubility

Methanol; Acetontrile; Water; DMSO

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

JXTOWLUQSHIIDP-IGMIGKIRSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:23643-61-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27565758

Abstract

In this work, a sensitive and selective UPLC-MS/MS method for determination of ardisiacrispin A in rat plasma was developed. Cyasterone used as an internal standard (IS) and protein precipitation by acetonitrile-methanol (9:1, v/v) was used to prepare samples. Chromatographic separation was achieved on a UPLC BEH C18 column (2.1 × 100 mm, 1.7 μm) with 0.1% formic acid and acetonitrile as the mobile phase with gradient elution. An electrospray ionization source was applied and operated in positive ion mode; multiple reaction monitoring mode was used for quantification using target fragment ions m/z 1083.5 → 407.1 for ardisiacrispin A and m/z 521.3 → 485.2 for IS. Calibration plots were linear throughout the range 5-2000 ng/mL for ardisiacrispin A in rat plasma. Mean recoveries of ardisiacrispin A in rat plasma ranged from 80.4 to 92.6%. The values of RSD of intra- and inter-day precision were both <11%. The accuracy of the method was between 97.3 and 105.6%. The method was successfully applied to pharmacokinetic study of ardisiacrispin A after intravenous administration in rats. Copyright © 2016 John Wiley & Sons, Ltd.

KEYWORDS

UPLC-MS/MS; ardisiacrispin A; pharmacokinetics; rat plasma

Title

Pharmacokinetic study of ardisiacrispin A in rat plasma after intravenous administration by UPLC-MS/MS.

Author

Fang B1, Bao S2, Wang S3, Chen M3, Chen B4, Su K4, Wen C4, Zhou Y3, Wang X5, Jin Y6.

Publish date

2017 Mar

PMID

3432422

Title

Ardisiacrispin A and B, two utero-contracting saponins from Ardisia crispa.

Author

Jansakul C, Baumann H, Kenne L, Samuelsson G.

Publish date

1987 Oct