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Artemisinin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-A3024

  • Specification : 98%

  • CAS number : 63968-64-9

  • Formula : C15H22O5

  • Molecular Weight : 282.33

  • PUBCHEM ID : 68827

  • Volume : 100mg

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Catalogue Number

BF-A3024

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

282.33

Appearance

White crystalline powder

Botanical Source

Artemisia dubia,Artemisia carvifolia

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C

Synonyms

(3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one/(4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0.0]hexadecan-10-one/artemisininum/qinghausu/3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (5aS,6R,8aS,9R,12S,12aR)-/Artemisinin/ARTEANUIN/Quinghaosu/[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one/3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-/qinghaosu/QINGHAOSA/artemisinine/(+)-artemisinin/[3R-(3a,5ab,6b,8ab,9a,12b,12aR*)]-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one/qinghausau/ARTEMISINE/QHS/qinghosu/Arteannuin

IUPAC Name

(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one

Density

1.2±0.1 g/cm3

Solubility

Ethanol

Flash Point

172.0±27.9 °C

Boiling Point

389.9±42.0 °C at 760 mmHg

Melting Point

156-157ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:63968-64-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29193409

Abstract

Artemisinin is one of the most widely prescribed drugs against malaria and has recently received increased attention because of its other potential biological effects. The aim of this review is to summarize recent discoveries of the pharmaceutical effects of artemisinin in basic science along with its mechanistic action, as well as the intriguing results of recent clinical studies, with a focus on its antitumor activity. Scientific evidence indicates that artemisinin exerts its biological activity by generating reactive oxygen species that damage the DNA, mitochondrial depolarization, and cell death. In the present article review, scientific evidence suggests that artemisinin is a potential therapeutic agent for various diseases. Thus, this review is expected to encourage interested scientists to conduct further preclinical and clinical studies to evaluate these biological activities.

Copyright © 2017 John Wiley & Sons, Ltd.

KEYWORDS

antitumor activity; artemisinin; pharmacological activities

Title

More insights into the pharmacological effects of artemisinin.

Author

Zyad A1, Tilaoui M1, Jaafari A1, Oukerrou MA1, Mouse HA1.

Publish date

2018 Feb

PMID

28643446

Abstract

Artemisinin and its derivatives (collectively termed as artemisinins) are among the most important and effective antimalarial drugs, with proven safety and efficacy in clinical use. Beyond their antimalarial effects, artemisinins have also been shown to possess selective anticancer properties, demonstrating cytotoxic effects against a wide range of cancer types both in vitro and in vivo. These effects appear to be mediated by artemisinin-induced changes in multiple signaling pathways, interfering simultaneously with multiple hallmarks of cancer. Great strides have been taken to characterize these pathways and to reveal their anticancer mechanisms of action of artemisinin. Moreover, encouraging data have also been obtained from a limited number of clinical trials to support their anticancer property. However, there are several key gaps in knowledge that continue to serve as significant barriers to the repurposing of artemisinins as effective anticancer agents. This review focuses on important and emerging aspects of this field, highlighting breakthroughs in unresolved questions as well as novel techniques and approaches that have been taken in recent studies. We discuss the mechanism of artemisinin activation in cancer, novel and significant findings with regards to artemisinin target proteins and pathways, new understandings in artemisinin-induced cell death mechanisms, as well as the practical issues of repurposing artemisinin. We believe these will be important topics in realizing the potential of artemisinin and its derivatives as safe and potent anticancer agents.

© 2017 Wiley Periodicals, Inc.

KEYWORDS

anticancer; artemisinin; chemical proteomics; mechanism of action; targets identification

Title

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action.

Author

Wong YK1, Xu C2, Kalesh KA3, He Y2, Lin Q2, Wong WSF4, Shen HM1, Wang J1.

Publish date

2017 Nov

PMID

28643446

Abstract

Artemisinin and its derivatives (collectively termed as artemisinins) are among the most important and effective antimalarial drugs, with proven safety and efficacy in clinical use. Beyond their antimalarial effects, artemisinins have also been shown to possess selective anticancer properties, demonstrating cytotoxic effects against a wide range of cancer types both in vitro and in vivo. These effects appear to be mediated by artemisinin-induced changes in multiple signaling pathways, interfering simultaneously with multiple hallmarks of cancer. Great strides have been taken to characterize these pathways and to reveal their anticancer mechanisms of action of artemisinin. Moreover, encouraging data have also been obtained from a limited number of clinical trials to support their anticancer property. However, there are several key gaps in knowledge that continue to serve as significant barriers to the repurposing of artemisinins as effective anticancer agents. This review focuses on important and emerging aspects of this field, highlighting breakthroughs in unresolved questions as well as novel techniques and approaches that have been taken in recent studies. We discuss the mechanism of artemisinin activation in cancer, novel and significant findings with regards to artemisinin target proteins and pathways, new understandings in artemisinin-induced cell death mechanisms, as well as the practical issues of repurposing artemisinin. We believe these will be important topics in realizing the potential of artemisinin and its derivatives as safe and potent anticancer agents.

© 2017 Wiley Periodicals, Inc.

KEYWORDS

anticancer; artemisinin; chemical proteomics; mechanism of action; targets identification

Title

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action.

Author

Wong YK1, Xu C2, Kalesh KA3, He Y2, Lin Q2, Wong WSF4, Shen HM1, Wang J1

Publish date

2017 Nov


Description :

Artemisinin is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants.