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Asperulosidic acid methyl ester

$572

  • Brand : BIOFRON

  • Catalogue Number : BD-P0649

  • Specification : 98.0%(HPLC)

  • CAS number : 14260-99-2

  • Formula : C19H26O12

  • Molecular Weight : 446.4

  • PUBCHEM ID : 21602024

  • Volume : 10mg

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Catalogue Number

BD-P0649

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

446.4

Appearance

Powder

Botanical Source

"Daphniphyllum macropodum; Gardenia jasminoides, Plantago lagopus and Mussaenda pubescens. Component of Zhi Zi"

Structure Type

Iridoids

Category

SMILES

CC(=O)OCC1=CC(C2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O

Synonyms

methyl (1S,4aS,5S,7aS)-7-(acetyloxymethyl)-5-hydroxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate

IUPAC Name

methyl (1S,4aS,5S,7aS)-7-(acetyloxymethyl)-5-hydroxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate

Applications

Density

1.6±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

237.7±25.0 °C

Boiling Point

678.3±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C19H26O12/c1-7(21)28-5-8-3-10(22)13-9(17(26)27-2)6-29-18(12(8)13)31-19-16(25)15(24)14(23)11(4-20)30-19/h3,6,10-16,18-20,22-25H,4-5H2,1-2H3/t10-,11+,12+,13-,14+,15-,16+,18-,19-/m0/s1

InChl Key

YSOBQIMODQOGKQ-HOZAMIDDSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:14260-99-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

Title

Proceedings from the 9th annual conference on the science of dissemination and implementation Washington, DC, USA. 14-15 December 2016

Author

David Chambers,1 Lisa Simpson,2 Gila Neta,1 Ulrica von Thiele Schwarz,3 Antoinette Percy-Laurry,4 Gregory A. Aarons,5 Gila Neta,6 Ross Brownson,7 Amanda Vogel,8 Shannon Wiltsey Stirman,9 Kenneth Sherr,10 Rachel Sturke,11 Wynne E. Norton,12 Allyson Varley,13 David Chambers,12 Cynthia Vinson,14 Lisa Klesges,14,15 Suzanne Heurtin-Roberts,14 M. Rashad Massoud,16 Leighann Kimble,16 Arne Beck,17 Claire Neely,corresponding author18 Jennifer Boggs,17 Carmel Nichols,corresponding author19 Wen Wan,19 Erin Staab,19 Neda Laiteerapong,19 Nathalie Moise,corresponding author20 Ravi Shah,21 Susan Essock,21 Margaret Handley,22 Amy Jones,23 Jay Carruthers,23 Karina Davidson,20 Lauren Peccoralo,24 Lloyd Sederer,23 Todd Molfenter,corresponding author25 Ashley Scudder,26 Sarah Taber-Thomas,26,27 Kristen Schaffner,26 Amy Herschell,corresponding author26,28 Eva Woodward,corresponding author29 Jeffery Pitcock,30 Mona Ritchie,30 JoAnn Kirchner,30,31 Julia E. Moore,corresponding author32 Sobia Khan,32 Shusmita Rashid,32 Jamie Park,32 Melissa Courvoisier,32 Sharon Straus,32,33 Daniel Blonigen,corresponding author34,35 Allison Rodriguez,36 Luisa Manfredi,34 Andrea Nevedal,34,37 Joel Rosenthal,38 David Smelson,39,40 Christine Timko,34 Nicole Stadnick,corresponding author41 Jennifer Regan,42 Miya Barnett,43 Anna Lau,44 Lauren Brookman-Frazee,41 Erick Guerrero,corresponding author45 Karissa Fenwick,46 Yinfei Kong,47 Gregory Aarons,48 Rebecca Lengnick-Hall,corresponding author49 Karissa Fenwick,49 Benjamin Henwood,49 Nina Sayer,corresponding author50,51 Craig Rosen,52,53 Robert Orazem,50 Brandy Smith,52,54 Craig Rosen,corresponding author55,56,57 Lindsey Zimmerman,corresponding author58,59 David Lounsbury,60,61 Craig Rosen,58,62,63 Rachel Kimerling,58 Jodie A. Trafton,61,63,64 Steven Lindley,61,65 Rahul Bhargava,corresponding author66,67 Hal Roberts,corresponding author68 Laura Gibson,corresponding author69 Gabriel J. Escobar,corresponding author70 Vincent Liu,71 Benjamin Turk,71 Arona Ragins,71 Patricia Kipnis,72 Ashley Ketterer Gruszkowski,corresponding author73 Michael W. Kennedy,73 Emily Rentschler Drobek,73 Lior Turgeman,74 Aleksandra Sasha Milicevic,74 Terrence L. Hubert,73 Larissa Myaskovsky,73,75,76 Youxu C. Tjader,74 Robert J. Monte,73 Kathryn G. Sapnas,77 Edmond Ramly,corresponding author78 Diane R Lauver,79 Christie M Bartels,80 Shereef Elnahal,corresponding author81 Andrea Ippolito,82 Hillary Peabody,83 Carolyn Clancy,81 Randall Cebul,corresponding author84 Thomas Love,84,85 Douglas Einstadter,84,86 Shari Bolen,84,87 Brook Watts,corresponding author88,89 Vera Yakovchenko,corresponding author90,91 Angela Park,92 William Lukesh,92 Donald R. Miller,90,91 David Thornton,93 Mari-Lynn Drainoni,90,91,94 Allen L. Gifford,90,91,95 Shawna Smith,corresponding author96 Julia Kyle,97 Mark S Bauer,98,99 Daniel Eisenberg,100 Celeste Liebrecht,97,101 Michelle Barbaresso,97,101 Amy Kilbourne,97,102,103 Elyse Park,corresponding author104 Giselle Perez,104 Jamie Ostroff,105 Sarah Greene,corresponding author106 Michael Parchman,107 Brian Austin,107 Eric Larson,107 Stefanie Ferreri,corresponding author108 Chris Shea,109 Megan Smith,110 Kea Turner,111 Jennifer Bacci,corresponding author112 Kyle Bigham,112 Geoffrey Curran,113 Stefanie Ferreri,114 Caity Frail,115 Cory Hamata,112 Terry Jankowski,116 Wendy Lantaff,117 Melissa Somma McGivney,118 Margie Snyder,117 Megan McCullough,corresponding author119,120 Chris Gillespie,119 Beth Ann Petrakis,119 Ellen Jones,121 Angela Park,122 Carol VanDeusen Lukas,123,124 Adam Rose,119,125 Sarah J. Shoemaker,corresponding author126 Geoffrey Curran,127 Jeremy Thomas,127 Benjamin Teeter,127 Holly Swan,126 Benjamin Teeter,corresponding author128 Jeremy Thomas,128 Geoffrey Curran,128 Appathurai Balamurugan,129 Meghan Lane-Fall,corresponding author130,131,132 Rinad Beidas,131,133 Laura Di Taranti,130 Sruthi Buddai,130 Enrique Torres Hernandez,134 Jerome Watts,135 Lee Fleisher,130,131 Frances Barg,130,136 Isomi Miake-Lye,corresponding author137 Tanya Olmos,138 Emmeline Chuang,137 Hector Rodriguez,139 Gerald Kominski,140 Becky Yano,137,141 Stephen Shortell,142 Mary Hook,corresponding author143 Linda Fleisher,corresponding author144,145 Alexander Fiks,146 Katie Halkyard,144 Rachel Gruver,144 Emily Sykes,144 Kimberly Vesco,corresponding author147,148 Kate Beadle,149 Joanna Bulkley,147 Ashley Stoneburner,147 Michael Leo,147 Amanda Clark,147,148 Joan Smith,corresponding author150 Christopher Smyser,151 Maggie Wolf,150 Shamik Trivedi,152 Brian Hackett,153 Rakesh Rao,153 F. Sessions Cole,153 Rose McGonigle,154 Ann Donze,155 Enola Proctor,156 Amit Mathur,157 Kenneth Sherr,corresponding author158 Emmanuela Gakidou,158 Stephen Gloyd,158 Carolyn Audet,corresponding author159 Jose Salato,160 Sten Vermund,161 Rivet Amico,162 Stephanie Smith,corresponding author163,164 Beatha Nyirandagijimana,165 Hildegarde Mukasakindi,165 Christian Rusangwa,166 Molly Franke,167 Giuseppe Raviola,163,167 Matthew Cummings,168 Elijah Goldberg,169 Savio Mwaka,169 Olive Kabajaasi,169 Adithya Cattamanchi,170 Achilles Katamba,171 Shevin Jacob,172 Nathan Kenya-Mugisha,169 J. Lucian Davis,corresponding author173 Julie Reed,174 Rohit Ramaswamy,corresponding author175 Gareth Parry,176 Sylvia Sax,177 Heather Kaplan,178 Keng-yen Huang,corresponding author179 Sabrina Cheng,179 Susan Yee,179 Kimberly Hoagwood,180 Mary McKay,181,182 Donna Shelley,179 Gbenga Ogedegbe,183 Laurie Miller Brotman,179 Roman Kislov,184 John Humphreys,185 Gill Harvey,186 Paul Wilson,corresponding author184 Robert Lieberthal,corresponding author187,188,189 Colleen Payton,190 Mona Sarfaty,190 George Valko,190 Rendelle Bolton,corresponding author191 Carol VanDeusen Lukas,192 Christine Hartmann,193,194 Nora Mueller,195 Sally K. Holmes,194,196 Barbara Bokhour,191,194 Sarah Ono,corresponding author197,198 Benjamin Crabtree,199 Leah Gordon,197 William Miller,200 Bijal Balasubramanian,201 Leif Solberg,202 Deborah Cohen,197 Kate McGraw,corresponding author203 Andrew Blatt,204 Demietrice Pittman,205 Megan McCullough,corresponding author206,207 Christine Hartmann,206,207 Helen Kales,208,209 Dan Berlowitz,206,207 Teresa Hudson,210,211 Chris Gillespie,206 Christian Helfrich,212,213 Erin Finley,corresponding author214,215 Ashley Garcia,216 Kristen Rosen,216 Claudina Tami,216 Don McGeary,216 Mary Jo Pugh,215 Jennifer Sharpe Potter,216 Christian Helfrich,corresponding author217,218 Krysttel Stryczek,219 David Au,219 Steven Zeliadt,217,218,219 George Sayre,218,219 Chris Gillespie,220 Jennifer Leeman,corresponding author221 Allison Myers,222 Jennifer Grant,222 Mary Wangen,223 Tara Queen,224 Alexandra Morshed,corresponding author225,226 Elizabeth Dodson,226,227 Rachel Tabak,226 Ross C. Brownson,225,226 R. Chris Sheldrick,corresponding author228 Thomas Mackie,229 Justeen Hyde,230,231 Laurel Leslie,232 Itzhak Yanovitzky,corresponding author233 Matthew Weber,233 Nicole Gesualdo,233 Teis Kristensen,233 Cameo Stanick,corresponding author234 Heather Halko,235 Caitlin Dorsey,236 Byron Powell,237 Bryan Weiner,238 Cara Lewis,239 Byron Powell,corresponding author240 Bryan Weiner,241 Cameo Stanick,242 Heather Halko,243 Caitlin Dorsey,244 Cara Lewis,245 Bryan Weiner,corresponding author246 Caitlin Dorsey,247 Cameo Stanick,248 Heather Halko,249 Byron Powell,250 Cara Lewis,251 Shannon Wiltsey Stirman,corresponding author252,253 Patricia Carreno,253 Kera Mallard,253 Tasoula Masina,254 Candice Monson,254 Taren Swindle,corresponding author255 Geoffrey Curran,256 Zachary Patterson,255 Leanne Whiteside-Mansell,255 Rochelle Hanson,corresponding author257 Benjamin Saunders,258 Sonja Schoenwald,257 Angela Moreland,258 Sarah Birken,corresponding author259 Byron Powell,259 Justin Presseau,260,261,262 Isomi Miake-Lye,corresponding author263,264 David Ganz,265,266 Brian Mittman,265,267 Deborah Delevan,265 Erin Finley,268,269 Jennifer N. Hill,corresponding author270 Sara Locatelli,270 Barbara Bokhour,271,272 Gemmae Fix,271,272 Jeffrey Solomon,273 Nora Mueller,274 Sherri L. Lavela,270,275,276 Victoria Scott,277 Jonathan Scaccia,corresponding author278 Kassy Alia,279 Brittany Skiles,279 Abraham Wandersman,279 Paul Wilson,corresponding author280 Anne Sales,corresponding author281,282 Megan Roberts,corresponding author283 Amy Kennedy,283 David Chambers,283 Muin J. Khoury,284 Nina Sperber,corresponding author285,286 Lori Orlando,287 Janet Carpenter,288 Larisa Cavallari,289 Joshua Denny,290 Amanda Elsey,289 Fern Fitzhenry,290 Yue Guan,291 Carol Horowitz,292 Julie Johnson,289 Ebony Madden,293 Toni Pollin,291 Victoria Pratt,294 Tejinder Rakhra-Burris,295 Marc Rosenman,296 Corrine Voils,286,297 Kristin Weitzel,289 Ryanne Wu,286 Laura Damschroder,298 Christine Lu,corresponding author299 Rachel Ceccarelli,300 Kathleen M. Mazor,301 Ann Wu,299,300 Alanna Kulchak Rahm,corresponding author302 Adam H. Buchanan,302 Marci Schwartz,302 Cara McCormick,302 Kandamurugu Manickam,302 Marc S. Williams,302 Michael F. Murray,302 Ngoc-Cam Escoffery,corresponding author303 Erin Lebow-Skelley,303 Hallie Udelson,303 Elaine Böing,303 Maria E. Fernandez,304 Richard J. Wood,305 Patricia Dolan Mullen,304 Jenita Parekh,corresponding author306,307 Valerie Caldas,306 Elizabeth A. Stuart,308 Shalynn Howard,309 Gilo Thomas,310 Jacky M. Jennings,307 Jennifer Torres,corresponding author311 Christine Markham,311 Ross Shegog,311 Melissa Peskin,311 Stephanie Craig Rushing,312 Amanda Gaston,313 Gwenda Gorman,314 Cornelia Jessen,315 Jennifer Williamson,315 Dianne Ward,corresponding author316,317 Amber Vaughn,317 Ellie Morris,317 Stephanie Mazzucca,316 Regan Burney,317 Shoba Ramanadhan,corresponding author318,319,321 Sara Minsky,318 Vilma Martinez-Dominguez,320 Kasisomayajula Viswanath,318,321 Megan Barker,corresponding author322,323 Myra Fahim,322,324 Arezoo Ebnahmady,322 Rosa Dragonetti,322 Peter Selby,322,323,325,326,327 Margaret Farrell,328 Jordan Tompkins,328 Wynne Norton,corresponding author328 Kaelin Rapport,328 Margaret Hargreaves,corresponding author329 Rebekka Lee,corresponding author330,333 Shoba Ramanadhan,330,331 Gina Kruse,332,333 Charles Deutsch,333 Emily Lanier,corresponding author334 Ashley Gray,334 Aaron Leppin,corresponding author335,336 Lori Christiansen,337 Karen Schaepe,336 Jason Egginton,336 Megan Branda,336 Charlene Gaw,338 Sara Dick,335 Victor Montori,339 Nilay Shah,336 Ariella Korn,corresponding author340 Peter Hovmand,341 Karen Fullerton,340 Nancy Zoellner,341 Erin Hennessy,342 Alison Tovar,343 Ross Hammond,344 Christina Economos,342 Christi Kay,corresponding author345 Julie Gazmararian,346 Emily Vall,347 Patricia Cheung,corresponding author348 Padra Franks,349 Shannon Barrett-Williams,349 Paul Weiss,350 Christi Kay,349 Julie Gazmararian,348 Erica Hamilton,corresponding author351 Patricia Cheung,352 Christi Kay,353 Emily Vall,354 Julie Gazmararian,352 Luana Marques,corresponding author355 Louise Dixon,356 Emily Ahles,357 Sarah Valentine,358 Candice Monson,359 Derri Shtasel,358 Shannon Wiltsey Stirman,corresponding author360 Ruben Parra-Cardona,corresponding author361 Mary Northridge,corresponding author362 Rucha Kavathe,363 Jennifer Zanowiak,364 Laura Wyatt,364 Hardayal Singh,365 Nadia Islam,364 Madalena Monteban,corresponding author366 Darcy Freedman,366,367 Kimberly Bess,368 Colleen Walsh,369 Kristen Matlack,367 Susan Flocke,366 Heather Baily,370 Samantha Harden,corresponding author371 NithyaPriya Ramalingam,372 VCE Physical Activity Leadership Team,373 Kassy Alia,corresponding author374 Jonathan Scaccia,375 Victoria Scott,376 Rohit Ramaswamy,377 Abraham Wandersman,374 Rachel Gold,corresponding author378,381 Erika Cottrell,379 Celine Hollombe,378 Katie Dambrun,381 Arwen Bunce,378 Mary Middendorf,380 Marla Dearing,381 Stuart Cowburn,381 Ned Mossman,381 Gerry Melgar,382 Suellen Hopfer,corresponding author383 Michael Hecht,384 Anne Ray,385 Michelle Miller-Day,386 Rhonda BeLue,387 Greg Zimet,388 Eve-Lynn Nelson,corresponding author389 Sandy Kuhlman,390 Gary Doolittle,391 Hope Krebill,392 Ashley Spaulding,392 Theodore Levin,corresponding author393 Michael Sanchez,394 Molly Landau,395 Patricia Escobar,394 Nadia Minian,corresponding author396 Peter Selby,397,398,399,400,401 Aliya Noormohamed,396 Laurie Zawertailo,398,402 Dolly Baliunas,398 Norman Giesbrecht,403 Bernard Le Foll,398,402 Andriy Samokhvalov,398 Zachary Meisel,corresponding author404 Daniel Polsky,405 Bruce Schackman,406 Julia Mitchell,405 Kaitlyn Sevarino,corresponding author407 Sarah Gimbel,corresponding author408,409,410 Moses Mwanza,411 Marie Paul Nisingizwe,412 Catherine Michel,413 Lisa Hirschhorn,414,415 Meghan Lane-Fall,corresponding author416 Rinad Beidas,417,418 Laura Di Taranti,416 Mahrukh Choudhary,416 Della Thonduparambil,416 Lee Fleisher,416,418 Frances Barg,416,419 Paul Meissner,corresponding author420 Hilary Pinnock,421 Melanie Barwick,422 Christopher Carpenter,423 Sandra Eldridge,424 Gonzalo Grandes-Odriozola,425 Chris Griffiths,424 Jo Rycroft-Malone,426 Elizabeth Murray,427 Anita Patel,428 Aziz Sheikh,421,429 Stephanie J. C. Taylor,424 Brian Mittman,430 Martin Guilliford,431 Gemma Pearce,432 Diane Korngiebel,corresponding author433 Kathleen West,434 Wylie Burke,435 Peggy Hannon,corresponding author436 Jeffrey Harris,436 Kristen Hammerback,436 Marlana Kohn,436 Gary K. C. Chan,437 Riki Mafune,438 Amanda Parrish,436 Christian Helfrich,436,439,440 Shirley Beresford,441 K. Joanne Pike,442 Rachel Shelton,corresponding author443 Lina Jandorf,444 Deborah Erwin,445 Thana-Ashley Charles,443 Michael Parchman,corresponding author446 Laura-Mae Baldwin,447 Brooke Ike,447 Jacqueline Fickel,corresponding author448 Jason Lind,449 Diane Cowper,450 Marguerite Fleming,451 Amy Sadler,452 Melinda Dye,453 Judith Katzburg,454 Michael Ong,455 Sarah Tubbesing,456,457 Megan McCullough,corresponding author458,459 Molly Simmons,458,459 Vera Yakovchenko,458,459 Autumn Harnish,458 Sonya Gabrielian,460,461 Keith McInnes,458,459 Jeffrey Smith,462 David Smelson,458,463 John Ferrand,corresponding author464 Elisa Torres,464 Amy Green,464 Gregory Aarons,464 Angela R. Bradbury,corresponding author465 Linda J. Patrick-Miller,466 Brian L. Egleston,467 Susan M. Domchek,468 Olufunmilayo I. Olopade,466 Michael J. Hall,469 Mary B. Daly,470 Linda Fleisher,471,472 Generosa Grana,473 Pamela Ganschow,474 Dominique Fetzer,468 Amanda Brandt,468 Rachelle Chambers,475 Dana F. Clark,473 Andrea Forman,470 Rikki S. Gaber,476 Cassandra Gulden,466 Janice Horte,477 Jessica Long,468 Terra Lucas,478 Shreshtha Madaan,479 Kristin Mattie,477 Danielle McKenna,468 Susan Montgomery,470 Sarah Nielsen,466 Jacquelyn Powers,468 Kim Rainey,470 Christina Rybak,470 Christina Seelaus,478 Jessica Stoll,466 Jill Stopfer,468 Xinxin Shirley Yao,477 Michelle Savage,470 Edward Miech,corresponding author480 Teresa Damush,481 Nicholas Rattray,482 Jennifer Myers,482 Barbara Homoya,482 Kate Winseck,corresponding author483 Carrie Klabunde,483 Deb Langer,483 Avi Aggarwal,483 Elizabeth Neilson,483 Lara Gunderson,corresponding author484 Gabriel J. Escobar,corresponding author485 Marla Gardner,485 Liam O’Sulleabhain,485 Candyce Kroenke,485 Vincent Liu,486 and Patricia Kipnis487

Publish date

2017

PMID

8517693

Abstract

Data obtained from 74 acutely ill patients treated in two clinical efficacy trials were used to develop a population model of the pharmacokinetics of intravenous (i.v.) ciprofloxacin. Dosage regimens ranged between 200 mg every 12 h and 400 mg every 8 h. Plasma samples (2 to 19 per patient; mean +/- standard deviation = 7 +/- 5) were obtained and assayed (by high-performance liquid chromatography) for ciprofloxacin. These data and patient covariates were modelled by iterative two-stage analysis, an approach which generates pharmacokinetic parameter values for both the population and each individual patient. The final model was used to implement a maximum a posteriori-Bayesian pharmacokinetic parameter value estimator. Optimal sampling theory was used to determine the best (maximally informative) two-, three-, four-, five-, and six-sample study designs (e.g., optimal sampling strategy 2 [OSS2] was the two-sample strategy) for identifying a patient’s pharmacokinetic parameter values. These OSSs and the population model were evaluated by selecting the relatively rich data sets, those with 7 to 10 samples obtained in a single dose interval (n = 29), and comparing the parameter estimates (obtained by the maximum a posteriori-Bayesian estimator) based on each of the OSSs with those obtained by fitting all of the available data from each patient. Distributional clearance and apparent volumes were significantly related to body size (e.g., weight in kilograms or body surface area in meters squared); plasma clearance (CLT in liters per hour) was related to body size and renal function (creatinine clearance [CLCR] in milliliters per minute per 1.73 m2) by the equation CLT = (0.00145.CLCR + 0.167).weight. However, only 30% of the variance in CLT was explained by this relationship, and no other patient covariates were significant. Compared with previously published data, this target population had smaller distribution volumes (by 30%; P < 0.01) and CLT (by 44%; P < 0.001) than weight- and CLCR- matched stable volunteers. OSSs provided parameter estimates that showed good to excellent estimates of CLT (or area under the concentrations-time curve [AUC]) were unbiased and precise (e.g., r2 for AUC for all data versus AUC for OSS2 was > 0.99) and concentration-time profiles were accurately reconstructed. These results will be used to model the pharmacodynamic relationships between ciprofloxacin exposure and response and to aid in developing algorithms for individual optimization of ciprofloxacin dosage regimens.

Title

Development of a population pharmacokinetic model and optimal sampling strategies for intravenous ciprofloxacin.

Author

A Forrest, C H Ballow, D E Nix, M C Birmingham, and J J Schentag

Publish date

1993 May

PMID

23201644

Abstract

Bioflocculant-producing bacteria were isolated from activated sludge of a wastewater treatment plant located in Durban, South Africa, and identified using standard biochemical tests as well as the analysis of their 16S rRNA gene sequences. The bioflocculants produced by these organisms were ethanol precipitated, purified using 2% (w/v) cetylpyridinium chloride solution and evaluated for removal of wastewater dyes under different pH, temperature and nutritional conditions. Bioflocculants from these indigenous bacteria were very effective for decolourizing the different dyes tested in this study, with a removal rate of up to 97.04%. The decolourization efficiency was largely influenced by the type of dye, pH, temperature, and flocculant concentration. A pH of 7 was found to be optimum for the removal of both whale and mediblue dyes, while the optimum pH for fawn and mixed dye removal was found to be between 9 and 10. Optimum temperature for whale and mediblue dye removal was 35 °C, and that for fawn and mixed dye varied between 40-45 °C and 35-40 °C, respectively. These bacterial bioflocculants may provide an economical and cleaner alternative to replace or supplement present treatment processes for the removal of dyes from wastewater effluents, since they are biodegradable and easily sustainable.

KEYWORDS

bioflocculant, decolourization, dyes, flocculation, wastewater effluents

Title

Textile Dye Removal from Wastewater Effluents Using Bioflocculants Produced by Indigenous Bacterial Isolates

Author

Simphiwe P. Buthelezi, Ademola O. Olaniran,* and Balakrishna Pillay

Publish date

2012 Dec;