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Axitinib

$221

  • Brand : BIOFRON

  • Catalogue Number : BN-O1223

  • Specification : 98%(HPLC)

  • CAS number : 319460-85-0

  • Formula : C22H18N4OS

  • Molecular Weight : 386.47

  • PUBCHEM ID : 6450551

  • Volume : 5mg

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Catalogue Number

BN-O1223

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

386.47

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4

Synonyms

N-Methyl-2-({3-[(E)-2-(2-pyridinyl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide/Benzamide, N-methyl-2-[[3-[(E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-/Inlyta/Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-/10mg/Axitinib (usan)/N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide/AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide/Axtinib/AVERMECTINB/Axitinib/N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide/[14C]-Axitinib

IUPAC Name

Density

1.4±0.1 g/cm3

Solubility

Flash Point

358.3±31.5 °C

Boiling Point

668.9±55.0 °C at 760 mmHg

Melting Point

213-215ºC

InChl

InChl Key

RITAVMQDGBJQJZ-FMIVXFBMSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:319460-85-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29999904

Title

Axitinib

Publish date

2018 Dec 3.

PMID

30247703

Abstract

The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently it’s been implicated in energy metabolism, tumor progression, and cancer therapy as well. It is, therefore, important to identify compounds that induce human CAR (hCAR) activation to predict drug-drug interactions and potential therapeutic usage. In this study, we screen the Tox21 10,000 compound collection to characterize hCAR activators. A potential novel structural cluster of compounds was identified, which included nitazoxanide and tenonitrozole, whereas known structural clusters, such as flavones and prazoles, were also detected. Four compounds, neticonazole, diphenamid, phenothrin, and rimcazole, have been identified as novel hCAR activators, one of which, rimcazole, shows potential selectivity toward hCAR over its sister receptor, the pregnane X receptor (PXR). All 4 compounds translocated hCAR from the cytoplasm into the nucleus demonstrating the first step to CAR activation. Profiling these compounds as hCAR activators would enable an estimation of drug-drug interactions, as well as identify prospective therapeutically beneficial drugs.

KEYWORDS

constitutive androstane receptor, quantitative high-throughput screening, human primary hepatocytes, drug-drug interactions

Title

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Author

Caitlin Lynch,1 Bryan Mackowiak,2 Ruili Huang,1 Linhao Li,2 Scott Heyward,3 Srilatha Sakamuru,1 Hongbing Wang,2 and Menghang Xia1

Publish date

2019 Jan;


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