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Baicalein

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-B3010

  • Specification : 98%

  • CAS number : 491-67-8

  • Formula : C15H10O5

  • Molecular Weight : 270.24

  • PUBCHEM ID : 5281605

  • Volume : 25mg

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Catalogue Number

BF-B3010

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

270.24

Appearance

Yellow crystalline powder

Botanical Source

Scutellaria baicalensis,Erigeron breviscapus,Clerodendranthus spicatus,Croton crassifolius,Oxytropis microphylla

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O

Synonyms

4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL/Noroxylin/5,6,7-TRIHYDROXYFLAVONE/Baicalein/5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one/Baicelein/Baicalin

IUPAC Name

5,6,7-trihydroxy-2-phenylchromen-4-one

Density

1.5±0.1 g/cm3

Solubility

Methanol; Ethanol

Flash Point

225.3±23.6 °C

Boiling Point

575.9±50.0 °C at 760 mmHg

Melting Point

256-271 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:491-67-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28922719

Abstract

In recent times, neurodegenerative diseases are the most challenging global health problems. Neuronal cell death or damage is a key factor for many neurodegenerative disorders. Therefore, there has been a growing interest in the development of effective neuroprotective agents, especially from natural sources. In particular, phytochemicals have shown high efficacy with low side effects in various in vitro and in vivo studies. In the various phytoconstituents, flavonoids are important bioactive products and mainly found in various vegetables and fruits. Among them, baicalein is one of the important flavones, which is mainly found in the root of Scutellaria baicalensis Georgi. A number of studies have reported that baicalein has potent neuroprotective properties under in vitro as well as in vivo systems. Hence, the purpose of this paper is to provide a review of the existing literature in connection with the neuroprotective effects of baicalein and its molecular mechanisms of action. The current review highlights could be useful to identify novel therapeutic agents in relation to the treatment of neurotoxicity-mediated diseases.

Copyright © 2017 Elsevier Masson SAS. All rights reserved.

KEYWORDS

Alzheimer’s disease; Baicalein; Neuroprotective; Parkinson’s disease; Scutellaria baicalensis

Title

Baicalein as a potent neuroprotective agent: A review.

Author

Sowndhararajan K1, Deepa P1, Kim M1, Park SJ1, Kim S2.

Publish date

2017 Nov

PMID

28659545

Abstract

Baicalein, a typical flavonoid compound, has neuroprotective properties in several neurological disorders. Autophagy plays a central role in maintaining the cellular homeostasis, and is involved in the pathogenesis of Parkinson’s disease (PD). Recently, baicalein has been reported to induce autophagy. Therefore, the current study was designed to investigate whether baicalein could protect against rotenone-induced neurotoxicity via induction of autophagy both in SH-SY5Y cells and in a mouse model. A chronic PD mouse model was established by continuous intragastric administration of rotenone for 12 weeks. Baicalein was administrated from 7 to 12 week. Our results showed that baicalein prevented rotenone-induced behavioral deficits, dopaminergic neuronal loss, apoptosis and mitochondrial dysfunction. Furthermore, baicalein restored rotenone-impaired autophagy, and blocking the baicalein-induced autophagy using 3-methyladenine inhibited the neuroprotective effects of bacalein. Baicalein increased cell viability and restored mitochondrial function in SH-SY5Y cells. The beneficial effect of baicalein was abrogated by 3-methyladenine treatment. Furthermore, rapamycin increased autopahgy and reduced the rotenone-induced neurotoxicity in SH-SY5Y cells. Collectively, these results suggest that baicalein could prevent rotenone-induced neurotoxicity via restoring autophagy.

KEYWORDS

Parkinson’s disease; autophagy; baicalein; neuroprotection

Title

Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy.

Author

Kuang L1, Cao X1, Lu Z1.

Publish date

2017 Sep 1

PMID

28415048

Abstract

Baicalein, a bioactive flavonoid, exhibits anti-inflammatory and anti-cancer activities. However, few studies reported the interaction of baicalein with chemotherapeutic agents. Our study showed that baicalein significantly enhanced the chemosensitivity of cisplatin (CDDP) in vivo and in vitro. We found that A549/CDDP (resistant to CDDP) cells not only acquired epithelial-mesenchymal transition (EMT) phenotype, but also showed increased NF-κB activity compared with A549 cells (sensitive to CDDP). Our study further demonstrated that PI3K/Akt/NF-κB pathway controlled CDDP resistance via EMT and NF-κB-mediated apoptosis. Baicalein significantly suppressed the PI3K/Akt/NF-κB pathway, leading to conversion of EMT to mesenchymal-epithelial transition (MET, the reciprocal mesenchymal to epithelial transition), and inhibition of NF-κB-mediated antiapoptotic proteins in A549/CDDP cells. In conclusion, our study demonstrated that baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin by inhibiting EMT and attenuating apoptosis via PI3K/Akt/NF-κB pathway.

Copyright © 2017 Elsevier Masson SAS. All rights reserved.

KEYWORDS

Baicalein; Cisplatin; Epithelial-mesenchymal transition; PI3K/Akt/NF-κB pathway

Title

Baicalein increases cisplatin sensitivity of A549 lung adenocarcinoma cells via PI3K/Akt/NF-κB pathway.

Author

Yu M1, Qi B2, Xiaoxiang W3, Xu J1, Liu X4.

Publish date

2017 Jun


Description :

Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 mM.