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Baicalin

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-B3009

  • Specification : 98%

  • CAS number : 21967-41-9

  • Formula : C21H18O11

  • Molecular Weight : 446.36

  • PUBCHEM ID : 64982

  • Volume : 100mg

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Catalogue Number

BF-B3009

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

446.36

Appearance

Yellow crystalline powder

Botanical Source

Scutellaria baicalensis,Scutellaria barbata

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O

Synonyms

5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl β-D-Glucopyranosiduronic Acid/Acide α-D-glucopyranosiduronique de 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yle/BAICALIN/Baicaloside/5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl a-D-glucopyranosiduronic acid/Baicailin/(2S,3S,4S,5R,6R)-6-[(5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid/4H-1-Benzopyran-4-one, 7-(α-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-phenyl-/Baicalein 7-O-β-D-glucuronide/Bassora/Radix/baicalein 7-O-glucuronide/5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl α-D-glucopyranosiduronic acid

IUPAC Name

(2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

Density

1.7±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

297.2±27.8 °C

Boiling Point

836.6±65.0 °C at 760 mmHg

Melting Point

231-233 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:21967-41-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30209794

Abstract

Baicalin is one of the major bioactive components of Scutellaria radix, a Chinese herb that has been used since ancient times. Baicalin has various pharmacological activities, including antitumor, antimicrobial, and antioxidant, and has wide clinical applications. Baicalin displays a distinct pharmacokinetic profile including gastrointestinal hydrolysis, enterohepatic recycling, carrier-mediated transport, and complicated metabolism. The in vivo disposition of baicalin is affected by combinations of other herbs and baicalin can interact with other co-administered drugs due to competition between metabolic enzymes and protein binding. Furthermore, baicalin exhibits altered pharmacokinetic properties under different pathological conditions. Due to its low bioavailability, emerging novel baicalin preparations including nano/micro-scale baicalin delivery systems show better absorption and higher bioavailability in preclinical studies, and show promise for future clinical applications. Thus, this current review offers a comprehensive report on the pharmacokinetic behavior of baicalin and strategies to improve its bioavailability.

Title

Pharmacokinetics and Bioavailability Enhancement of Baicalin: A Review

Author

Ting Huang 1 2 , Yanan Liu 1 , Chengliang Zhang 3

Publish date

2019 Apr

PMID

29672961

Abstract

The use and significance of baicalin, the main bioactive component found in Radix Scutellaria, have been on the rise due to its interesting pharmacological properties. Baicalin, a low passive permeability compound, is directly absorbed from the upper intestine and its hepatic elimination is dominant. However, interaction but no transport studies have implicated organic anion‐transporting polypeptides in its cellular uptake. By using mammalian cells stably expressing the uptake transporters of interest, we are showing that baicalin is a potent substrate of Organic anion‐transporting polypeptide 2B1 (OATP2B1) and less potent substrate of OATP1B3. OATP2B1 and OATP1B3 transport baicalin and may play a role in the hepatic uptake of baicalin formed in the intestine.

Title

Baicalin Is a Substrate of OATP2B1 and OATP1B3

Author

Bernadett Kalapos-Kovacs 1 2 , Viktoria Juhasz 2 , Csilla Temesszentandrasi-Ambrus 2 , Balazs Magda 3 , Pal T Szabo 3 , Istvan Antal 1 , Imre Klebovich 1 , Peter Krajcsi 2 4

Publish date

2018 Aug;

PMID

29253124

Abstract

Osteomyelitis is an inflammation of bone caused by invading organisms. TLR2, inflammatory cytokines and mitogen-activated protein kinase (MAPK) signaling pathway are involved in osteomyelitis. Baicalin, the major active constituent of the isolated root of Scutellaria lateriflora Georgi, has been shown to have anti-inflammatory effects. In this study, the potentials of baicalin against osteomyelitis were evaluated. We treated mice and MC3T3-E1 cells with baicalin together with Staphylococcus aureus infection, and then analyzed the mice bone destruction, the expressions of TLR2 and osteogenic marker, the serum levels of proinflammatory factors and activation of MAPK signaling pathway. We also knocked down TLR2 by shRNA in MC3T3-E1 cells and detected the role of TLR2 in baicalin mediated inhibition of osteomyelitis. It was found that baicalin alleviated bone destruction in osteomyelitis. Baicalin decreased TLR2, alkaline phosphatase, osteopontin and collagen type I expressions. Baicalin decreased serum levels of proinflammatory factors IL-1β, IL-6 and CRP. Baicalin inhibited activation of MAPK signaling pathway. The inhibition of osteomyelitis by baicalin depended on TLR2 inhibition. In summary, baicalin is able to alleviate osteomyelitis by regulating TLR2.

Title

Baicalin Alleviates Osteomyelitis by Regulating TLR2 in the Murine Model

Author

Tianyi Wu 1 , Zhenjun Weng 1 , Jia Xu 1 , Gen Wen 1 , Yaling Yu 1 , Yimin Chai 1

Publish date

2018 Mar 1


Description :

Baicalin is a flavonoid glycoside isolated from Scutellaria baicalensis. Baicalin reduces the expression of NF-κB.