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provides coniferyl ferulate(CAS#:56684-87-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Neuroblastoma (NB) is a childhood solid malignant tumor originating from precursor cells of the peripheral nervous system. We have previously established a risk classification system based on DNA copy number profiles. To further explore the pathogenesis of NBs in distinct risk groups, we performed whole-exome sequencing analysis of 57 primary and 7 recurrent/metastatic tumors with unique chromosomal aberration profiles as categorized by our genomic sub-grouping system. Overall, a low frequency of somatic mutations was found. Besides ALK (4/64, 6.3%), SEMA6C, SLIT1 and NRAS, genes involved in the axon guidance pathway, were identified as recurrently mutated in 6 of 64 tumors (9.4%). Pathway enrichment analysis revealed enrichment of 25 mutated genes in the mitogen-activated protein kinase (MAPK) pathway, 13 genes in the Wnt pathway, and 12 genes in the axon guidance pathway. Genomic analyses demonstrated that primary and matched recurrent or metastatic tumors obtained from sporadic and monozygotic twin NBs were clonally related with variable extents of genetic heterogeneity. Monozygotic twin NBs displayed different evolutionary trajectories. These results indicate the involvement of the axon guidance, MAPK and Wnt pathways in NB and demonstrate genomic diversity with NB progression.
whole-exome sequencing, array CGH, neuroblastoma, familial neuroblastoma, genomic diversity
Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway
Yuanyuan Li,#1,2 Miki Ohira,#3,4 Yong Zhou,#5 Teng Xiong,#5 Wen Luo,5 Chao Yang,5 Xiangchun Li,5 Zhibo Gao,5 Rui Zhou,5 Yohko Nakamura,2 Takehiko Kamijo,4 Yasuhiko Kaneko,4 Takeshi Taketani,6 Junichi Ueyama,7 Tatsuro Tajiri,8 Hongyan Zhang,5 Jian Wang,5,9 Huanming Yang,5,9 Ye Yin,5 and Akira Nakagawara1,2
2017 Aug 22;
Evolutionary theories of seasonal migration generally assume that the costs of longer migrations are balanced by benefits at the non‐breeding destinations.
We tested, and rejected, the null hypothesis of equal survival and timing of spring migration for High Arctic breeding sanderling Calidris alba using six and eight winter destinations between 55°N and 25°S, respectively.
Annual apparent survival was considerably lower for adult birds wintering in tropical West Africa (Mauritania: 0.74 and Ghana: 0.75) than in three European sites (0.84, 0.84 and 0.87) and in subtropical Namibia (0.85). Moreover, compared with adults, second calendar‐year sanderlings in the tropics, but not in Europe, often refrained from migrating north during the first possible breeding season. During northward migration, tropical‐wintering sanderlings occurred at their final staging site in Iceland 5-15 days later than birds wintering further north or south. Namibia‐wintering sanderlings tracked with solar geolocators only staged in West Africa during southward migration.
The low annual survival, the later age of first northward migration and the later passage through Iceland during northward migration of tropical‐wintering sanderlings, in addition to the skipping of this area during northward but not southward migration by Namibia‐wintering sanderlings, all suggest they face issues during the late non‐breeding season in West Africa.
Migrating sanderlings defy long distances but may end up in winter areas with poor fitness prospects. We suggest that ecological conditions in tropical West Africa make the fuelling prior to northward departure problematic.
demography, fitness, migration, nutrient storage strategies, site fidelity, solar geolocation, survival, timing
Low fitness at low latitudes: Wintering in the tropics increases migratory delays and mortality rates in an Arctic breeding shorebird
Jeroen Reneerkens,corresponding author 1 Tom S. L. Versluijs, 1 Theunis Piersma, 1 , 2 Jose A. Alves, 3 , 4 Mark Boorman, 5 Colin Corse, 6 Olivier Gilg, 7 , 8 Gunnar Thor Hallgrimsson, 9 Johannes Lang, 8 , 10 Bob Loos, 11 Yaa Ntiamoa‐Baidu, 12 , 13 Alfred A. Nuoh, 12 Peter M. Potts, 14 Job ten Horn, 2 and Tamar Lok 2
The equimolar reaction between a racemic mixture of (R)- and (S)-camphorquinone with thiosemicarbazide yielded the title compound, C11H17N3OS [common name: (R)- and (S)-camphor thiosemicarbazone], which maintains the chirality of the methylated chiral carbon atoms and crystallizes in the centrosymmetric space group C2/c. There are two molecules in general positions in the asymmetric unit, one of them being the (1R)-camphor thiosemicarbazone isomer and the second the (1S)- isomer. In the crystal, the molecular units are linked by C—H⋯S, N—H⋯O and N—H⋯S interactions, building a tape-like structure parallel to the (An external file that holds a picture, illustration, etc.
Object name is e-76-00115-efi1.jpg01) plane, generating R 2 1(7) and R 2 2(8) graph-set motifs for the H⋯S interactions. The Hirshfeld surface analysis indicates that the major contributions for crystal cohesion are from H⋯H (55.00%), H⋯S (22.00%), H⋯N (8.90%) and H⋯O (8.40%) interactions.
chiral thiosemicarbazone, camphor derivative, racemic mixture, crystal structure
Synthesis, crystal structure and Hirshfeld analysis of a crystalline compound comprising a 1/1 mixture of 1-[(1R,4S)- and 1-[(1S,4R)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptan-3-ylidene]hydrazinecarbothioamide
Fabricio Carvalho Pires,a Leandro Bresolin,a,* Vanessa Carratu Gervini,a Barbara Tirloni,b and Adriano Bof de Oliveirac
2020 Jan 1;