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Benzo-15-crown 5-ether

$72

  • Brand : BIOFRON

  • Catalogue Number : BN-O1082

  • Specification : 98%(HPLC)

  • CAS number : 14098-44-3

  • Formula : C14H20O5

  • Molecular Weight : 268.3

  • PUBCHEM ID : 84197

  • Volume : 5mg

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Catalogue Number

BN-O1082

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

268.3

Appearance

Botanical Source

Structure Type

Category

SMILES

C1COCCOC2=CC=CC=C2OCCOCCO1

Synonyms

benzo-15-crown-5/2,3,5,6,8,9,11,12-Octahydro-1,4,7,10,13-benzopentaoxacyclopentadecine/Benzo-15-crown 5-Ether/1,4,7,10,13-Benzopentaoxacyclopentadecin, 2,3,5,6,8,9,11,12-octahydro-/2,5,8,11,14-pentaoxabicyclo[13.4.0]nonadeca-1(19),15,17-triene/2,3,5,6,8,9,11,12-Octahydrobenzo[b][1,4,7,10,13]pentaoxacyclopentadecine/2,3-Benzo-1,4,7,10,13-pentaoxacyclopentadec-2-ene

IUPAC Name

2,5,8,11,14-pentaoxabicyclo[13.4.0]nonadeca-1(19),15,17-triene

Density

1.1±0.1 g/cm3

Solubility

Flash Point

165.9±27.8 °C

Boiling Point

399.2±42.0 °C at 760 mmHg

Melting Point

78-80 °C(lit.)

InChl

InChl Key

FNEPSTUXZLEUCK-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:14098-44-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28102363

Abstract

Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no single therapeutic agent has been identified as synthetically lethal with SMARCA4/BRG1 loss. We identify AURKA activity as essential in NSCLC cells lacking SMARCA4/BRG1. In these cells, RNAi-mediated depletion or chemical inhibition of AURKA induces apoptosis and cell death in vitro and in xenograft mouse models. Disc large homologue-associated protein 5 (HURP/DLGAP5), required for AURKA-dependent, centrosome-independent mitotic spindle assembly is essential for the survival and proliferation of SMARCA4/BRG1 mutant but not of SMARCA4/BRG1 wild-type cells. AURKA inhibitors may provide a therapeutic strategy for biomarker-driven clinical studies to treat the NSCLCs harbouring SMARCA4/BRG1-inactivating mutations.

Title

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Author

Vural Tagal,1 Shuguang Wei,1 Wei Zhang,2,3 Rolf A. Brekken,3,4,5 Bruce A. Posner,1,5 Michael Peyton,3 Luc Girard,3,4 TaeHyun Hwang,6 David A. Wheeler,7 John D. Minna,3,4,5,8 Michael A. White,5,9 Adi F. Gazdar,2,3,5 and Michael G. Rotha,1,5

Publish date

2017;

PMID

23986245

Abstract

Synesthesia is a condition in which normal stimuli can trigger anomalous associations. In this study, we exploit synesthesia to understand how the synesthetic experience can be explained by subtle changes in network properties. Of the many forms of synesthesia, we focus on colored sequence synesthesia, a form in which colors are associated with overlearned sequences, such as numbers and letters (graphemes). Previous studies have characterized synesthesia using resting-state connectivity or stimulus-driven analyses, but it remains unclear how network properties change as synesthetes move from one condition to another. To address this gap, we used functional MRI in humans to identify grapheme-specific brain regions, thereby constructing a functional “synesthetic” network. We then explored functional connectivity of color and grapheme regions during a synesthesia-inducing fMRI paradigm involving rest, auditory grapheme stimulation, and audiovisual grapheme stimulation. Using Markov networks to represent direct relationships between regions, we found that synesthetes had more connections during rest and auditory conditions. We then expanded the network space to include 90 anatomical regions, revealing that synesthetes tightly cluster in visual regions, whereas controls cluster in parietal and frontal regions. Together, these results suggest that synesthetes have increased connectivity between grapheme and color regions, and that synesthetes use visual regions to a greater extent than controls when presented with dynamic grapheme stimulation. These data suggest that synesthesia is better characterized by studying global network dynamics than by individual properties of a single brain region.

Title

Neural Networks of Colored Sequence Synesthesia

Author

Steffie N. Tomson, Manjari Narayan, Genevera I. Allen, David M. Eagleman

Publish date

2013 Aug 28;

PMID

23530047

Abstract

In this work, the purification and characterization of an extracellular elicitor protein, designated AsES, produced by an avirulent isolate of the strawberry pathogen Acremonium strictum, are reported. The defense eliciting activity present in culture filtrates was recovered and purified by ultrafiltration (cutoff, 30 kDa), anionic exchange (Q-Sepharose, pH 7.5), and hydrophobic interaction (phenyl-Sepharose) chromatographies. Two-dimensional SDS-PAGE of the purified active fraction revealed a single spot of 34 kDa and pI 8.8. HPLC (C2/C18) and MS/MS analysis confirmed purification to homogeneity. Foliar spray with AsES provided a total systemic protection against anthracnose disease in strawberry, accompanied by the expression of defense-related genes (i.e. PR1 and Chi2-1). Accumulation of reactive oxygen species (e.g. H2O2 and O2˙̄) and callose was also observed in Arabidopsis. By using degenerate primers designed from the partial amino acid sequences and rapid amplification reactions of cDNA ends, the complete AsES-coding cDNA of 1167 nucleotides was obtained. The deduced amino acid sequence showed significant identity with fungal serine proteinases of the subtilisin family, indicating that AsES is synthesized as a larger precursor containing a 15-residue secretory signal peptide and a 90-residue peptidase inhibitor I9 domain in addition to the 283-residue mature protein. AsES exhibited proteolytic activity in vitro, and its resistance eliciting activity was eliminated when inhibited with PMSF, suggesting that its proteolytic activity is required to induce the defense response. This is, to our knowledge, the first report of a fungal subtilisin that shows eliciting activity in plants. This finding could contribute to develop disease biocontrol strategies in plants by activating its innate immunity

KEYWORDS

Mass Spectrometry (MS), Plant Defense, Protein Purification, Protein Sequence, Serine Protease, Acremonium strictum, Elicitor, Fragaria x ananassa, Subtilisin, cDNA Sequencing

Title

Purification and Characterization of AsES Protein: A SUBTILISIN SECRETED BY ACREMONIUM STRICTUM IS A NOVEL PLANT DEFENSE ELICITOR

Author

Nadia R. Chalfoun, Carlos F. Grellet-Bournonville, Martin G. Martinez-Zamora, Araceli Diaz-Perales, Atilio P. Castagnaro, Juan C. Diaz-Ricci

Publish date

2013 May 17;


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