2,1,3-Benzoxadiazole,1-oxide/Benzofurazan,1-oxide/benzofuroxane/benzofurazan N-oxide/Benzofuroxan/2,1,3-Benzoxadiazole 1-Oxide/Benzofurazan 1-Oxide/Benzofurazan oxide
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provides coniferyl ferulate(CAS#:480-96-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Editorial (Thematic Issue: Hybrid Compounds as Multitarget Agents in Medicinal Chemistry - Part II)
Luciana Scotti 1, Francisco Jaime Bezerra Mendonca-Junior 2, Marcus T Scotti 1
Hybrid drug strategy is based on the combination of two or more pharmacophores into a new chemical entity to improve the properties of the original compounds or to obtain double action of resulting molecule. Hybrid molecules, comprised of some pharmacophore and nitric oxide (NO) donor moiety, constitute one of the more promising approaches for the design of drugs. Furoxans and benzofuroxans are considered NO releasing prodrugs and are of great interest for researchers. In this review we will focus on furoxan and benzofuroxan hybrids described in literature during the last years (from 2005 to 2016).
Benzofuroxan; Furoxan; Hybrid; NO-donor; Pharmacophore..
Novel Structural Hybrids on the Base of Benzofuroxans and Furoxans. Mini-Review
Elena A Chugunova 1, Alexander R Burilov 1
On the basis of the strategy of “multifunctional drugs”, a series of novel matrix metalloproteinase inhibitors (MMPIs) containing benzofuroxan scaffold as a nitric oxide donor were designed, synthesized and evaluated. All synthesized compounds, especially 16a, exhibited potent MMP-2,9 inhibitory activities, anti-proliferative activities and could produce high levels of NO in Hela cells. They were also evaluated for both of their anti-invasion and anti-angiogenesis effects. Furthermore, compared with LY52, 16a demonstrated competitive antitumor activity in vivo. These hybrid NO-MMPIs might offer suitable scaffolds to develop valuable MMP inhibitors for the further discovery of novel anti-cancer drugs.
Benzofuroxan; MMP inhibitor; Multifunctional drugs; Nitric oxide; Synthesis.
Synthesis and Biological Evaluation of Novel Benzofuroxan-Based Pyrrolidine Hydroxamates as Matrix Metalloproteinase Inhibitors With Nitric Oxide Releasing Activity
Hao Zhang 1, Xuejian Wang 2, Jing Mao 1, Yongxue Huang 3, Wenfang Xu 4, Yu Duan 5, Jian Zhang 6
2018 Aug 15