We Offer Worldwide Shipping
Login Wishlist

Benzofuroxan

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1072

  • Specification : 98%(HPLC)

  • CAS number : 480-96-6

  • Formula : C6H4N2O2

  • Molecular Weight : 136.11

  • PUBCHEM ID : 68075

  • Volume : 5mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O1072

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

136.11

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC2=NO[N+](=C2C=C1)[O-]

Synonyms

2,1,3-Benzoxadiazole,1-oxide/Benzofurazan,1-oxide/benzofuroxane/benzofurazan N-oxide/Benzofuroxan/2,1,3-Benzoxadiazole 1-Oxide/Benzofurazan 1-Oxide/Benzofurazan oxide

IUPAC Name

3-oxido-2,1,3-benzoxadiazol-3-ium

Density

1.49 g/cm3

Solubility

Flash Point

102.7ºC

Boiling Point

246.2ºC at 760 mmHg

Melting Point

66-69 °C

InChl

InChl Key

OKEAMBAZBICIFP-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:480-96-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28406075

Title

Editorial (Thematic Issue: Hybrid Compounds as Multitarget Agents in Medicinal Chemistry - Part II)

Author

Luciana Scotti 1, Francisco Jaime Bezerra Mendonca-Junior 2, Marcus T Scotti 1

Publish date

2017

PMID

27697059

Abstract

Hybrid drug strategy is based on the combination of two or more pharmacophores into a new chemical entity to improve the properties of the original compounds or to obtain double action of resulting molecule. Hybrid molecules, comprised of some pharmacophore and nitric oxide (NO) donor moiety, constitute one of the more promising approaches for the design of drugs. Furoxans and benzofuroxans are considered NO releasing prodrugs and are of great interest for researchers. In this review we will focus on furoxan and benzofuroxan hybrids described in literature during the last years (from 2005 to 2016).

KEYWORDS

Benzofuroxan; Furoxan; Hybrid; NO-donor; Pharmacophore..

Title

Novel Structural Hybrids on the Base of Benzofuroxans and Furoxans. Mini-Review

Author

Elena A Chugunova 1, Alexander R Burilov 1

Publish date

2017

PMID

30093347

Abstract

On the basis of the strategy of “multifunctional drugs”, a series of novel matrix metalloproteinase inhibitors (MMPIs) containing benzofuroxan scaffold as a nitric oxide donor were designed, synthesized and evaluated. All synthesized compounds, especially 16a, exhibited potent MMP-2,9 inhibitory activities, anti-proliferative activities and could produce high levels of NO in Hela cells. They were also evaluated for both of their anti-invasion and anti-angiogenesis effects. Furthermore, compared with LY52, 16a demonstrated competitive antitumor activity in vivo. These hybrid NO-MMPIs might offer suitable scaffolds to develop valuable MMP inhibitors for the further discovery of novel anti-cancer drugs.

KEYWORDS

Benzofuroxan; MMP inhibitor; Multifunctional drugs; Nitric oxide; Synthesis.

Title

Synthesis and Biological Evaluation of Novel Benzofuroxan-Based Pyrrolidine Hydroxamates as Matrix Metalloproteinase Inhibitors With Nitric Oxide Releasing Activity

Author

Hao Zhang 1, Xuejian Wang 2, Jing Mao 1, Yongxue Huang 3, Wenfang Xu 4, Yu Duan 5, Jian Zhang 6

Publish date

2018 Aug 15


Description :

Empty ...