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Benzoic acid

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-B2001

  • Specification : 98%

  • CAS number : 65-85-0

  • Formula : C7H6O2

  • Molecular Weight : 122.12

  • PUBCHEM ID : 243

  • Volume : 20mg

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Catalogue Number

BF-B2001

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

122.12

Appearance

White flake crystal

Botanical Source

Benzoin Gum

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC=C(C=C1)C(=O)O

Synonyms

Benzoic acid/Nalfurafine Impurity 10

IUPAC Name

benzoic acid

Density

1.2±0.1 g/cm3

Solubility

Slightly soluble. 0.34 g/100 mL

Flash Point

121.1±0.0 °C

Boiling Point

249.3±9.0 °C at 760 mmHg

Melting Point

121-125 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2916310000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:65-85-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31472355

Abstract

Fenton (Fe2+ + H2O2) reagents acting to remove organic pollutants possess dual functions, including the oxidation by hydroxyl radicals and the coagulation of Fe(III). Previous papers have extensively studied the oxidation reactions by hydroxyl radicals, however, the coagulation role of Fenton for benzoic acid (BA) removal is not clear. Comparing three coagulation systems, it was found that Fenton coagulation possesses a significant advantage for the removal of BA. Through Fenton conditional experiments, results showed that with the increase of H2O2 dosage, not only was the Fenton oxidation effect improved, but the Fenton coagulation effect was also significantly enhanced. Interestingly, the flocs produced by in situ Fenton possess a better coagulation effect than an aged Fenton system when processing BA. To further explain these results, Zeta potential, Transmission electron microscope (TEM), X-ray diffraction (XRD), X-ray absorption fine structure (EXAFS) and Brunner-Emmet-Teller (BET) measurements were used for characterization, and we found that the flocs produced by Fenton possessed a smaller particle size, lower polymerization states and a larger specific surface area and pore volume, which exposed more active sites to create a better coagulation effect. Additionally, through Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and Gas chromatography-mass spectrometer (GC-MS), we found that in situ Fenton oxidation and coagulation have synergistic effects, and the carboxyl-containing intermediates produced by the Fenton oxidation of BA can be combined with hydroxyl active sites of the flocs produced by in situ Fenton, resulting in a better removal effect. Finally, Fenton oxidation increases oxygen/carbon (O/C) to promote Fenton coagulation, and in situ Fenton more fully utilizes the active sites on the flocs’ surface.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS

Active sites; Coagulation; Flocs difference; In situ Fenton; Synergistic effects

Title

The role of in situ Fenton coagulation on the removal of benzoic acid.

Author

Han X1, Lu H2, Gao Y3, Chen X4, Yang M5.

Publish date

2020 Jan

PMID

31401897

Abstract

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.

KEYWORDS

Carbonic anhydrase inhibitor; carboxylic acid; molecular modelling; sulfoxide enantioseparation

Title

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold.

Author

Rotondi G1, Guglielmi P1, Carradori S2, Secci D1, De Monte C1, De Filippis B2, Maccallini C2, Amoroso R2, Cirilli R3, Akdemir A4, Angeli A5, Supuran CT5.

Publish date

2019 Dec

PMID

31376563

Abstract

The P2Y14 receptor (P2Y14R) plays a key role in the modulation of inflammatory process, but very few classes of antagonists have been reported. A series of 3-amide benzoic acid derivatives were identified as novel and potent P2Y14R antagonists. The most potent antagonist, 16c, showed comparable activity (IC50 = 1.77 nM) to PPTN, the most potent P2Y14R antagonist reported. Compound 16c demonstrated dramatically improved aqueous solubility and excellent metabolic stability in rat and human microsomes. Investigation of the anti-inflammatory effect of 16c was performed in MSU treated THP-1 cells by flow cytometry, Western Blot and immunofluorescence labeling technology, which exhibited that 16c might be a promising candidate for further research.

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

KEYWORDS

3-Amide benzoic acid derivatives; Antagonist; Anti-inflammation; G protein-coupled receptor; P2Y(14) receptor

Title

Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y14 receptor antagonists.

Author

Zhang Z1, Hao K2, Li H3, Lu R1, Liu C3, Zhou M3, Li B4, Meng Z4, Hu Q5, Jiang C6.

Publish date

2019 Nov 1


Description :

Benzoic Acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.